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Crohn’s disease patients effectively mobilize peripheral blood stem cells to perform autologous haematopoietic stem cell transplantation

View ORCID ProfileMilton Artur Ruiz, View ORCID ProfileRoberto Luiz Kaiser Junior, View ORCID ProfileLilian Piron – Ruiz, View ORCID ProfileTatiana Peña-Arciniegas, View ORCID ProfileLilian Castiglioni, View ORCID ProfilePriscila Samara Saran, View ORCID ProfileLuiz Gustavo De Quadros, View ORCID ProfileMikaell Alexandre Gouvea Faria, View ORCID ProfileRubens Camargo Siqueira, View ORCID ProfileFernanda Soubhia Liedtke Kaiser, José Francisco Comenalli Marques Junior
doi: https://doi.org/10.1101/348763
Milton Artur Ruiz
1Bone Marrow Transplant Department, Associação Portuguesa de Beneficencia São José do Rio Preto, SP, Brazil
2Kaiser Clinica, Centro Médico Avançado de São Jose do Rio Preto, São Paulo, Brazil
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Roberto Luiz Kaiser Junior
1Bone Marrow Transplant Department, Associação Portuguesa de Beneficencia São José do Rio Preto, SP, Brazil
2Kaiser Clinica, Centro Médico Avançado de São Jose do Rio Preto, São Paulo, Brazil
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Lilian Piron – Ruiz
1Bone Marrow Transplant Department, Associação Portuguesa de Beneficencia São José do Rio Preto, SP, Brazil
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Tatiana Peña-Arciniegas
1Bone Marrow Transplant Department, Associação Portuguesa de Beneficencia São José do Rio Preto, SP, Brazil
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Lilian Castiglioni
1Bone Marrow Transplant Department, Associação Portuguesa de Beneficencia São José do Rio Preto, SP, Brazil
3Faculdade de Medicina de São Jose do Rio Preto, SP, Brazil
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Priscila Samara Saran
1Bone Marrow Transplant Department, Associação Portuguesa de Beneficencia São José do Rio Preto, SP, Brazil
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Luiz Gustavo De Quadros
2Kaiser Clinica, Centro Médico Avançado de São Jose do Rio Preto, São Paulo, Brazil
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Mikaell Alexandre Gouvea Faria
2Kaiser Clinica, Centro Médico Avançado de São Jose do Rio Preto, São Paulo, Brazil
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Rubens Camargo Siqueira
4Faculdade de Medicina USP Ribeirao Preto, SP, Brazil.
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Fernanda Soubhia Liedtke Kaiser
2Kaiser Clinica, Centro Médico Avançado de São Jose do Rio Preto, São Paulo, Brazil
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José Francisco Comenalli Marques Junior
5Hemocentro da Unicamp, Campinas, SP, Brazil
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Abstract

Background Treatment with high doses chemotherapy followed by autologous haematopoietic stem cell transplantation is promising for refractory Crohn’s disease patients with no therapeutic option and at imminent risk of further surgeries.

Objectives To evaluate the feasibility and efficacy of haematopoietic progenitor cell mobilization in a group of Crohn’s disease patients preparing for autologous unselected haematopoietic stem cell transplantation in a single institution. This is the first study to evaluate mobilization for Crohn’s disease.

Methods Patients were selected according to criteria of the European Bone Marrow Transplant Society.

Results All patients mobilized with the mean number of haematopoietic progenitor cells obtained and infused being 16.17 × 106/CD34+/kg. Most patients required only one leukapheresis session to reach the ideal number of cells. Grafting occurred around ten days after cells infusion. Complications and adverse events during the mobilization period were rare with only one patient presenting sepsis as a relevant event in the period.

Most patients 20 (70%) had anaemia from the beginning of the mobilization but only 11 (37.9%) received packed red blood cell transfusions.

Conclusion Mobilization in patients with Crohn’s disease is effective and it seems they are good mobilizers.

Footnotes

  • Ruiz MA and Kaiser Junior RL conceived the study and drafted the manuscript. All the authors approved the final version of the article.

  • Conflict-of-interest statement: The authors have no conflict of interest to declare.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted June 17, 2018.
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Crohn’s disease patients effectively mobilize peripheral blood stem cells to perform autologous haematopoietic stem cell transplantation
Milton Artur Ruiz, Roberto Luiz Kaiser Junior, Lilian Piron – Ruiz, Tatiana Peña-Arciniegas, Lilian Castiglioni, Priscila Samara Saran, Luiz Gustavo De Quadros, Mikaell Alexandre Gouvea Faria, Rubens Camargo Siqueira, Fernanda Soubhia Liedtke Kaiser, José Francisco Comenalli Marques Junior
bioRxiv 348763; doi: https://doi.org/10.1101/348763
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Crohn’s disease patients effectively mobilize peripheral blood stem cells to perform autologous haematopoietic stem cell transplantation
Milton Artur Ruiz, Roberto Luiz Kaiser Junior, Lilian Piron – Ruiz, Tatiana Peña-Arciniegas, Lilian Castiglioni, Priscila Samara Saran, Luiz Gustavo De Quadros, Mikaell Alexandre Gouvea Faria, Rubens Camargo Siqueira, Fernanda Soubhia Liedtke Kaiser, José Francisco Comenalli Marques Junior
bioRxiv 348763; doi: https://doi.org/10.1101/348763

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