New Results
Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
Jahir M. Gutierrez, Amir Feizi, Shangzhong Li, Thomas B. Kallehauge, Hooman Hefzi, Lise M. Grav, Daniel Ley, Deniz Baycin Hizal, Michael J. Betenbaugh, Bjorn Voldborg, Helene Faustrup Kildegaard, Gyun Min Lee, Bernhard O. Palsson, Jens Nielsen, View ORCID ProfileNathan E. Lewis
doi: https://doi.org/10.1101/351387
Jahir M. Gutierrez
1Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, United States
2Novo Nordisk Foundation Center for Biosustainability at the University of California, San Diego, School of Medicine, La Jolla, CA 92093, United States
Amir Feizi
3Department of Biology and Biological Engineering, Kemivägen 10, Chalmers University of Technology, SE41296 Gothenburg, Sweden
Shangzhong Li
1Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, United States
2Novo Nordisk Foundation Center for Biosustainability at the University of California, San Diego, School of Medicine, La Jolla, CA 92093, United States
Thomas B. Kallehauge
4Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
Hooman Hefzi
1Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, United States
2Novo Nordisk Foundation Center for Biosustainability at the University of California, San Diego, School of Medicine, La Jolla, CA 92093, United States
Lise M. Grav
4Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
Daniel Ley
4Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
5Department of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark
Deniz Baycin Hizal
6Pharmaceutical R&D Department, Turgut Illaclari A.S., Istanbul, Turkey
Michael J. Betenbaugh
7Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218-2686, United States
Bjorn Voldborg
4Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
Helene Faustrup Kildegaard
4Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
Gyun Min Lee
4Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
Bernhard O. Palsson
1Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, United States
2Novo Nordisk Foundation Center for Biosustainability at the University of California, San Diego, School of Medicine, La Jolla, CA 92093, United States
4Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
8Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, CA 92093, United States
Jens Nielsen
3Department of Biology and Biological Engineering, Kemivägen 10, Chalmers University of Technology, SE41296 Gothenburg, Sweden
4Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
Nathan E. Lewis
2Novo Nordisk Foundation Center for Biosustainability at the University of California, San Diego, School of Medicine, La Jolla, CA 92093, United States
8Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, CA 92093, United States
Article usage
Posted November 10, 2019.
Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
Jahir M. Gutierrez, Amir Feizi, Shangzhong Li, Thomas B. Kallehauge, Hooman Hefzi, Lise M. Grav, Daniel Ley, Deniz Baycin Hizal, Michael J. Betenbaugh, Bjorn Voldborg, Helene Faustrup Kildegaard, Gyun Min Lee, Bernhard O. Palsson, Jens Nielsen, Nathan E. Lewis
bioRxiv 351387; doi: https://doi.org/10.1101/351387
Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
Jahir M. Gutierrez, Amir Feizi, Shangzhong Li, Thomas B. Kallehauge, Hooman Hefzi, Lise M. Grav, Daniel Ley, Deniz Baycin Hizal, Michael J. Betenbaugh, Bjorn Voldborg, Helene Faustrup Kildegaard, Gyun Min Lee, Bernhard O. Palsson, Jens Nielsen, Nathan E. Lewis
bioRxiv 351387; doi: https://doi.org/10.1101/351387
Subject Areas
- Biochemistry (11730)
- Bioengineering (8743)
- Bioinformatics (29179)
- Biophysics (14964)
- Cancer Biology (12080)
- Cell Biology (17399)
- Clinical Trials (138)
- Developmental Biology (9417)
- Ecology (14174)
- Epidemiology (2067)
- Evolutionary Biology (18294)
- Genetics (12233)
- Genomics (16791)
- Immunology (11858)
- Microbiology (28051)
- Molecular Biology (11575)
- Neuroscience (60919)
- Paleontology (451)
- Pathology (1870)
- Pharmacology and Toxicology (3238)
- Physiology (4955)
- Plant Biology (10422)
- Synthetic Biology (2881)
- Systems Biology (7338)
- Zoology (1650)