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Rod signaling in primate retina: range, routing and kinetics

William N Grimes, Jacob Baudin, Anthony Azevedo, View ORCID ProfileFred Rieke
doi: https://doi.org/10.1101/352419
William N Grimes
Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, US
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Jacob Baudin
Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, US
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Anthony Azevedo
Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, US
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Fred Rieke
Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, US
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  • ORCID record for Fred Rieke
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Abstract

Stimulus or context dependent routing of neural signals through parallel pathways can permit flexible processing of diverse inputs. For example, work in mouse shows that rod photoreceptor signals are routed through several retinal pathways, each specialized for different light levels. This light level-dependent routing of rod signals has been invoked to explain several human perceptual results, but it has not been tested in primate retina. Here we show, surprisingly, that rod signals traverse the primate retina almost exclusively through a single pathway, regardless of light level. Indeed, identical experiments in mouse and primate reveal large differences in how rod signals traverse the retina. These results require reevaluating human perceptual results in terms of flexible computation within this single pathway. This includes a prominent speeding of rod signals with light level – which we show is inherited directly from the rods photoreceptors themselves rather than from different pathways with different kinetics.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted June 20, 2018.
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Rod signaling in primate retina: range, routing and kinetics
William N Grimes, Jacob Baudin, Anthony Azevedo, Fred Rieke
bioRxiv 352419; doi: https://doi.org/10.1101/352419
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Rod signaling in primate retina: range, routing and kinetics
William N Grimes, Jacob Baudin, Anthony Azevedo, Fred Rieke
bioRxiv 352419; doi: https://doi.org/10.1101/352419

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