New Results
Protein-Coding Variants Implicate Novel Genes Related to Lipid Homeostasis Contributing to Body Fat Distribution
Anne E Justice, Tugce Karaderi, Heather M Highland, Kristin L Young, Mariaelisa Graff, Yingchang Lu, Valérie Turcot, Paul L Auer, Rebecca S Fine, Xiuqing Guo, Claudia Schurmann, Adelheid Lempradl, Eirini Marouli, Anubha Mahajan, Thomas W Winkler, Adam E Locke, Carolina Medina-Gomez, Tõnu Esko, Sailaja Vedantam, Ayush Giri, Ken Sin Lo, Tamuno Alfred, Poorva Mudgal, Maggie CY Ng, Nancy L Heard-Costa, Mary F Feitosa, Alisa K Manning, Sara M Willems, Suthesh Sivapalaratnam, Goncalo Abecasis, Dewan S Alam, Matthew Allison, Philippe Amouyel, Zorayr Arzumanyan, Beverley Balkau, Lisa Bastarache, Sven Bergmann, Lawrence F Bielak, Matthias Blüher, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Carsten A Boger, Jette Bork-Jensen, Erwin P Bottinger, Donald W Bowden, Ivan Brandslund, Linda Broer, Amber A Burt, Adam S Butterworth, Mark J Caulfield, Giancarlo Cesana, John C Chambers, Daniel I Chasman, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, Francis S Collins, James P Cook, Amanda J Cox, David S Crosslin, John Danesh, Paul IW de Bakker, Simon de Denus, Renee de Mutsert, George Dedoussis, Ellen W Demerath, Joe G Dennis, Josh C Denny, Emanuele Di Angelantonio, Marcus Dorr, Fotios Drenos, Marie-Pierre Dube, Alison M Dunning, Douglas F Easton, Paul Elliott, Evangelos Evangelou, Aliki-Eleni Farmaki, Shuang Feng, Ele Ferrannini, Jean Ferrieres, Jose C Florez, Myriam Fornage, Caroline S Fox, Paul W Franks, Nele Friedrich, Wei Gan, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Giorgia Girotto, Mathias Gorski, Harald Grallert, Niels Grarup, Megan L Grove, Stefan Gustafsson, Jeff Haessler, Torben Hansen, Andrew T Hattersley, Caroline Hayward, Iris M Heid, Oddgeir L Holmen, G Kees Hovingh, Joanna MM Howson, Yao Hu, Yi-Jen Hung, Kristian Hveem, M Arfan Ikram, Erik Ingelsson, Anne U Jackson, Gail P Jarvik, Yucheng Jia, Torben Jørgensen, Pekka Jousilahti, Johanne M Justesen, Bratati Kahali, Maria Karaleftheri, Sharon LR Kardia, Fredrik Karpe, Frank Kee, Hidetoshi Kitajima, Pirjo Komulainen, Jaspal S Kooner, Peter Kovacs, Bernhard K Kramer, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo A Lakka, David Lamparter, Leslie A Lange, Claudia Langenberg, Eric B Larson, Nanette R Lee, Wen-Jane Lee, Terho Lehtimäki, Cora E Lewis, Huaixing Li, Jin Li, Ruifang Li-Gao, Li-An Lin, Xu Lin, Lars Lind, Jaana Lindström, Allan Linneberg, Ching-Ti Liu, Dajiang J Liu, Jian’an Luan, Leo-Pekka Lyytikäinen, Stuart MacGregor, Reedik Mägi, Satu Männistö, Gaëlle Marenne, Jonathan Marten, Nicholas GD Masca, Mark I McCarthy, Karina Meidtner, Evelin Mihailov, Leena Moilanen, Marie Moitry, Dennis O Mook-Kanamori, Anna Morgan, Andrew P Morris, Martina Muller-Nurasyid, Patricia B Munroe, Narisu Narisu, Christopher P Nelson, Matt Neville, Ioanna Ntalla, Jeffrey R O’Connel, Katharine R Owen, Oluf Pedersen, Gina M Peloso, Craig E Pennell, Markus Perola, James A Perry, John RB Perry, Tune H Pers, Ailith Pirie, Ozren Polasek, Olli T Raitakari, Asif Rasheed, Chelsea K Raulerson, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Paul M Ridker, Manuel A Rivas, Neil R Robertson, Antonietta Robino, Igor Rudan, Katherine S Ruth, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Pamela J Schreiner, Matthias B Schulze, Robert A Scott, Marcelo P Segura-Lepe, Xueling Sim, Andrew J Slater, Kerrin S Small, Blair H Smith, Jennifer A Smith, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, Kari Stefansson, Valgerdur Steinthorsdottir, Kathleen E Stirrups, Konstantin Strauch, Heather M Stringham, Michael Stumvoll, Liang Sun, Praveen Surendran, Karin MA Swart, Jean-Claude Tardif, Kent D Taylor, Alexander Teumer, Deborah J Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Betina H Thuesen, Anke Tönjes, Mina Torres, Emmanouil Tsafantakis, Jaakko Tuomilehto, André G Uitterlinden, Matti Uusitupa, Cornelia M van Duijn, Mauno Vanhala, Rohit Varma, Sita H Vermeulen, Henrik Vestergaard, Veronique Vitart, Thomas F Vogt, Dragana Ntalla, Lynne E Wagenknecht, Mark Walker, Lars Wallentin, Feijie Wang, Carol A Wang, Shuai Wang, Nicholas J Wareham, Helen R Warren, Dawn M Waterworth, Jennifer Wessel, Harvey D White, Cristen J Willer, James G Wilson, Andrew R Wood, Ying Wu, Hanieh Yaghootkar, Jie Yao, Laura M Yerges-Armstrong, Robin Young, Eleftheria Zeggini, Xiaowei Zhan, Weihua Zhang, Jing Hua Zhao, Wei Zhao, He Zheng, Wei Zhou, M Carola Zillikens, GoT2D Genes Consortium CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Fernando Rivadeneira, Ingrid B Borecki, John A Pospisilik, Panos Deloukas, Timothy M Frayling, Guillaume Lettre, Karen L Mohlke, Jerome I Rotter, Zoltan Kutalik, Joel N Hirschhorn, L Adrienne Cupples, Ruth JF Loos, Kari E North, Cecilia M Lindgren
doi: https://doi.org/10.1101/352674
Anne E Justice
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27514, USABiomedical and Translational Informatics, Geisinger Health, Danville, PA 17822
Tugce Karaderi
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UKDepartment of Biological Sciences, Faculty of Arts and Sciences, Eastern Mediterranean University, Famagusta, Cyprus
Heather M Highland
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27514, USAHuman Genetics Center, The University of Texas School of Public Health, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA
Kristin L Young
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27514, USA
Mariaelisa Graff
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27514, USA
Yingchang Lu
Division of Epidemiology, Department of Medicine, Vanderbilt-lngram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, 37203, USAThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USAThe Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA
Valérie Turcot
Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, HIT 1C8, Canada
Paul L Auer
Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wl, 53201, USA
Rebecca S Fine
Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USADepartment of Genetics, Harvard Medical School, Boston, MA, 02115, USADivision of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA, 02115, USA
Xiuqing Guo
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA
Claudia Schurmann
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USAThe Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA
Adelheid Lempradl
Max Planck Institute of Immunobiology and Epigenetics, Freiburg, 79108, Germany
Eirini Marouli
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
Anubha Mahajan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UK
Thomas W Winkler
Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, Germany
Adam E Locke
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Ml, 48109, USAMcDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO, 63108, USA
Carolina Medina-Gomez
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The NetherlandsDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Tõnu Esko
Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USADivision of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA, 02115, USAEstonian Genome Center, University of Tartu, Tartu, 51010, Estonia
Sailaja Vedantam
Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USADepartment of Genetics, Harvard Medical School, Boston, MA, 02115, USADivision of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA, 02115, USA
Ayush Giri
Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, 37203, USA
Ken Sin Lo
Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, HIT 1C8, Canada
Tamuno Alfred
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA
Poorva Mudgal
Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA
Maggie CY Ng
Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USACenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA
Nancy L Heard-Costa
Department of Neurology, Boston University School of Medicine, Boston, MA, 02118, USANHLBI Framingham Heart Study, Framingham, MA, 01702, USA
Mary F Feitosa
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St.Louis, MO, 63108, USA
Alisa K Manning
Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USADepartment of Medicine, Harvard University Medical School, Boston, MA, 02115, USAMassachusetts General Hospital, Boston, MA, 02114, USA
Sara M Willems
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK
Suthesh Sivapalaratnam
Massachusetts General Hospital, Boston, MA, 02114, USADepartment of Vascular Medicine, AMC, Amsterdam, 1105 AZ, The NetherlandsDepartment of Haematology, University of Cambridge, Cambridge, CB2 OPT, UK
Goncalo Abecasis
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Ml, 48109, USA
Dewan S Alam
School of Kinesiology and Health Science, Faculty of Health, York University, Toronto
Matthew Allison
Department of Family Medicine & Public Health, University of California, San Diego, La Jolla, CA, 92093, USA
Philippe Amouyel
INSERM U1167, Lille, F-59019, FranceInstitut Pasteur de Lille, U1167, Lille, F-59019, FranceUniversite de Lille, U1167 - RID-AGE - Risk factors and molecular determinants of aging-related diseases, Lille, F-59019, France
Zorayr Arzumanyan
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA
Beverley Balkau
INSERM U1018, Centre de recherche en Epidemiologie et Santé des Populations (CESP), Villejuif, France
Lisa Bastarache
Department of Biomedical Informaties, Vanderbilt University, Nashville, TN, 37203, USA
Sven Bergmann
Department of Computational Biology, University of Lausanne, Lausanne, 1011, SwitzerlandSwiss Institute of Bioinformatics, Lausanne, 1015, Switzerland
Lawrence F Bielak
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Ml, 48109, USA
Matthias Blüher
IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, GermanyUniversity of Leipzig, Department of Medicine, Leipzig, 04103, Germany
Michael Boehnke
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Ml, 48109, USA
Heiner Boeing
Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DlfE), Nuthetal, 14558, Germany
Eric Boerwinkle
School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USAHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, 77030 USA
Carsten A Boger
Department of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany
Jette Bork-Jensen
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark
Erwin P Bottinger
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA
Donald W Bowden
Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USACenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USADepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA
Ivan Brandslund
Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, 7100, DenmarkInstitute of Regional Health Research, University of Southern Denmark, Odense, 5000, Denmark
Linda Broer
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Amber A Burt
Department of Medicine, University of Washington, Seattle, WA, 98195, USA
Adam S Butterworth
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UKNIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
Mark J Caulfield
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UKNIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
Giancarlo Cesana
Research Centre on Public Health, University of Milano-Bicocca, Monza, 20900, Italy
John C Chambers
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, SingaporeDepartment of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex, UB1 3HW, UKDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 IPG, UKImperial College Healthcare NHS Trust, London, W12 OHS, UKMRC-PHE Centre for Environment and Health, Imperial College London, London, W2 IPG, UK
Daniel I Chasman
Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USADivision of Genetics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 02115, USADivision of Preventive Medicine, Brigham and Women’s and Harvard Medical School, Boston, MA, 02215, USAHarvard Medical School, Boston, MA, 02115, USA
Yii-Der Ida Chen
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA
Rajiv Chowdhury
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
Cramer Christensen
Medical department, Lillebaelt Hospital, Vejle, 7100, Denmark
Audrey Y Chu
NHLBI Framingham Heart Study, Framingham, MA, 01702, USADivision of Preventive Medicine, Brigham and Women’s and Harvard Medical School, Boston, MA, 02215, USA
Francis S Collins
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA
James P Cook
Department of Biostatistics, University of Liverpool, Liverpool, L69 3GL, UK
Amanda J Cox
Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USACenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USAMenzies Health Institute Queensland, Griffith University, Southport, QLD, Australia
David S Crosslin
Department of Biomedical Infomatics and Medical Education, University of Washington, Seattle, WA, 98195, USA
John Danesh
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UKNIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UKWellcome Trust Sanger Institute, Hinxton, CB10 ISA, UKBritish Heart Foundation Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK
Paul IW de Bakker
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The NetherlandsDepartment of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
Simon de Denus
Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, HIT 1C8, CanadaFaculty of Pharmacy, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada
Renee de Mutsert
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands
George Dedoussis
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece
Ellen W Demerath
Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55454, USA
Joe G Dennis
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
Josh C Denny
Department of Biomedical Informaties, Vanderbilt University, Nashville, TN, 37203, USA
Emanuele Di Angelantonio
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UKNIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
Marcus Dorr
Department of Internal Medicine B, University Medicine Greifswald, Greifswald, 17475, GermanyDZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany
Fotios Drenos
Institute of Cardiovascular Science, University College London, London, WC1E 6JF, UKMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, UK
Marie-Pierre Dube
Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, HIT 1C8, CanadaDepartment of Medicine, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada
Alison M Dunning
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK
Douglas F Easton
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UKCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK
Paul Elliott
Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, W2 IPG, UK
Evangelos Evangelou
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 IPG, UKDepartment of Hygiene and Epidemiology, University of loannina Medical School, loannina, 45110, Greece
Aliki-Eleni Farmaki
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece
Shuang Feng
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Ml, 48109, USA
Ele Ferrannini
CNR Institute of Clinical Physiology, Pisa, ItalyDepartment of Clinical & Experimental Medicine, University of Pisa, Italy
Jean Ferrieres
Toulouse University School of Medicine, Toulouse, TSA 50032 31059, France
Jose C Florez
Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USADepartment of Medicine, Harvard University Medical School, Boston, MA, 02115, USAMassachusetts General Hospital, Boston, MA, 02114, USA
Myriam Fornage
Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA
Caroline S Fox
NHLBI Framingham Heart Study, Framingham, MA, 01702, USA
Paul W Franks
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, SE-20502, SwedenDepartment of Nutrition, Harvard School of Public Health, Boston, MA, 02115, USADepartment of Public Health and Clinical Medicine, Unit of Medicine, Umeâ University, Umeâ, 901 87, Sweden
Nele Friedrich
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, 17475, Germany
Wei Gan
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UK
Ilaria Gandin
Ilaria Gandin, Research Unit, AREA Science Park, Trieste, 34149, Italy
Paolo Gasparini
Department of Medical Sciences, University of Trieste, Trieste, 34137, ItalyInstitute for Maternal and Child Health - IRCCS ״Burlo Garofolo”, Trieste, Italy
Vilmantas Giedraitis
Geriatrics, Department of Public Health, Uppsala University, Uppsala, 751 85, Sweden
Giorgia Girotto
Department of Medical Sciences, University of Trieste, Trieste, 34137, ItalyInstitute for Maternal and Child Health - IRCCS ״Burlo Garofolo”, Trieste, Italy
Mathias Gorski
Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, GermanyDepartment of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany
Harald Grallert
German Center for Diabetes Research, München-Neuherberg, 85764, GermanyInstitute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, GermanyResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany
Niels Grarup
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark
Megan L Grove
School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA
Stefan Gustafsson
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, 751 41, Sweden
Jeff Haessler
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle WA, 98109, USA
Torben Hansen
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark
Andrew T Hattersley
University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK
Caroline Hayward
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
Iris M Heid
Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, GermanyInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany
Oddgeir L Holmen
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, NTNU, Norwegian University of Science and Technology, Trondheim, 7600, Norway
G Kees Hovingh
AMC, Department of Vascular Medicine, Amsterdam, 1105 AZ, The Netherlands
Joanna MM Howson
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
Yao Hu
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People’s Republic of China, Shanghai, 200031, China
Yi-Jen Hung
Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan 114, TaiwanSchool of Medicine, National Defense Medical Center, Taipei, Taiwan 114, Taiwan
Kristian Hveem
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, NTNU, Norwegian University of Science and Technology, Trondheim, 7600, NorwayHUNT Research center, Department of Public Health, Norwegian University of Science and Technology, Levanger, 7600, Norway
M Arfan Ikram
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The NetherlandsDepartment of Neurology, Erasmus Medical Center, Rotterdam, 3015 GE, The NetherlandsDepartment of Radiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Erik Ingelsson
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, 751 41, SwedenDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 943 05, USA
Anne U Jackson
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Ml, 48109, USA
Gail P Jarvik
Department of Medicine, University of Washington, Seattle, WA, 98195, USADepartment of Genome Sciences, University of Washington, Seattle, WA, 98195, USA
Yucheng Jia
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA
Torben Jørgensen
Faculty of medicine, Aalborg University, Aalborg, DK-9000, DenmarkDepartment of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, DenmarkResearch Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, Denmark
Pekka Jousilahti
National Institute for Health and Welfare, Helsinki, FI-00271, Finland
Johanne M Justesen
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark
Bratati Kahali
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Ml, 48109, USADepartment of Internal Medicine, University of Michigan, Ann Arbor, Ml, 48109, USADivision of Gastroenterology, University of Michigan, Ann Arbor, Ml, 48109, USACentre for Brain Research, Indian Institute of Science, Bangalore 560012, India
Maria Karaleftheri
Echinos Medical Centre, Echinos, Greece
Sharon LR Kardia
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Ml, 48109, USA
Fredrik Karpe
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UKOxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, OX3 7LE, UK
Frank Kee
UKCRC Centre of Excellence for Public Health Research, Queens University Belfast, Belfast, UK, BT12 6BJ, UK
Hidetoshi Kitajima
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UK
Pirjo Komulainen
Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, FinlandInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, 70210, FinlandDepartment of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
Jaspal S Kooner
Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex, UB1 3HW, UKImperial College Healthcare NHS Trust, London, W12 OHS, UKMRC-PHE Centre for Environment and Health, Imperial College London, London, W2 IPG, UKNational Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, London, W12 ONN, UK
Peter Kovacs
IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany
Bernhard K Kramer
University Medical Centre Mannheim, 5th Medical Department, University of Heidelberg, Mannheim, 68167, Germany
Kari Kuulasmaa
National Institute for Health and Welfare, Helsinki, FI-00271, Finland
Johanna Kuusisto
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland
Markku Laakso
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland
Timo A Lakka
Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, FinlandInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, 70210, FinlandDepartment of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
David Lamparter
Department of Computational Biology, University of Lausanne, Lausanne, 1011, SwitzerlandSwiss Institute of Bioinformatics, Lausanne, 1015, Switzerland
Leslie A Lange
Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA
Claudia Langenberg
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK
Eric B Larson
Department of Medicine, University of Washington, Seattle, WA, 98195, USAKaiser Permanente Washington Health Research Institute Seattle WA 98101Department of Health Services, University of Washington, Seattle WA 98101
Nanette R Lee
Department of Anthropology, Sociology, and History, University of San Carlos, Cebu City, 6000, PhilippinesUSC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, 6000, Philippines
Wen-Jane Lee
Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan 407, TaiwanDepartment of Social Work, Tunghai University, Taichung, Taiwan
Terho Lehtimäki
Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33521, FinlandDepartment of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland
Cora E Lewis
Division of Preventive Medicine University of Alabama at Birmingham, Birmingham, AL 35205, USA
Huaixing Li
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People’s Republic of China, Shanghai, 200031, China
Jin Li
Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Palo Alto, CA, 94304, USA
Ruifang Li-Gao
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands
Li-An Lin
Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA
Xu Lin
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People’s Republic of China, Shanghai, 200031, China
Lars Lind
Uppsala University, Uppsala, 75185, Sweden
Jaana Lindström
National Institute for Health and Welfare, Helsinki, FI-00271, Finland
Allan Linneberg
Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, DenmarkDepartment of Clinical Experimental Research, Rigshospitalet, Copenhagen, DK-2200, DenmarkDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark
Ching-Ti Liu
Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA
Dajiang J Liu
Department of Public Health Sciences, Institute for Personalized Medicine, the Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA
Jian’an Luan
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK
Leo-Pekka Lyytikäinen
Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33521, FinlandDepartment of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland
Stuart MacGregor
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia
Reedik Mägi
Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia
Satu Männistö
National Institute for Health and Welfare, Helsinki, FI-00271, Finland
Gaëlle Marenne
Wellcome Trust Sanger Institute, Hinxton, CB10 ISA, UK
Jonathan Marten
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
Nicholas GD Masca
Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UKNIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, LE3 9QP, UK
Mark I McCarthy
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UKOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UKOxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, OX3 7LE, UK
Karina Meidtner
German Center for Diabetes Research, München-Neuherberg, 85764, GermanyDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam- Rehbruecke (DlfE), Nuthetal, 14558, Germany
Evelin Mihailov
Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia
Leena Moilanen
Department of Medicine, Kuopio University Hospital, Kuopio, 70210, Finland
Marie Moitry
Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, F-67085, FranceDepartment of Public Health, University Hospital of Strasbourg, Strasbourg, F-67081, France
Dennis O Mook-Kanamori
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300RC, The NetherlandsDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2300RC, The Netherlands
Anna Morgan
Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy
Andrew P Morris
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UKDepartment of Biostatistics, University of Liverpool, Liverpool, L69 3GL, UK
Martina Muller-Nurasyid
Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, GermanyDepartment of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universitat, Munich, 81377, GermanyDZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, 80802, Germany
Patricia B Munroe
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UKNIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
Narisu Narisu
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA
Christopher P Nelson
Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UKNIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, LE3 9QP, UK
Matt Neville
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UKOxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, OX3 7LE, UK
Ioanna Ntalla
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
Jeffrey R O’Connel
Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, US
Katharine R Owen
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UKOxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, OX3 7LE, UK
Oluf Pedersen
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark
Gina M Peloso
Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA
Craig E Pennell
School of Women’s and Infants’ Health, The University of Western Australia, Perth, Western Australia, 6009, Australia
Markus Perola
National Institute for Health and Welfare, Helsinki, FI-00271, FinlandUniversity of Helsinki, Institute for Molecular Medicine (FIMM) and Diabetes and Obesity Research Program, Helsinki, FI00014, FinlandUniversity of Tartu, Estonian Genome Center, Tartu, Estonia, Tartu, 51010, Estonia
James A Perry
Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, US
John RB Perry
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK
Tune H Pers
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, DenmarkDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, 2200, Denmark
Ailith Pirie
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK
Ozren Polasek
School of Medicine, University of Split, Split, 21000, CroatiaCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK
Olli T Raitakari
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20521, FinlandResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland
Asif Rasheed
Centre for Non-Communicable Diseases, Karachi, Pakistan
Chelsea K Raulerson
Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA
Rainer Rauramaa
Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, FinlandInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, 70210, FinlandDepartment of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
Dermot F Reilly
Merck, Sharp & Dohme, Genetics and Pharmacogenomics, Boston, MA, 02115, USA
Alex P Reiner
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle WA, 98109, USADepartment of Epidemiology, University of Washington, Seattle, WA, 98195, USA
Paul M Ridker
Division of Preventive Medicine, Brigham and Women’s and Harvard Medical School, Boston, MA, 02215, USAHarvard Medical School, Boston, MA, 02115, USADivision of Cardiovascular Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 02115, USA
Manuel A Rivas
Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USANuffield Department of Clinical Medicine, Oxford, 0X37 BN, UK
Neil R Robertson
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UKOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UK
Antonietta Robino
Institute for Maternal and Child Health - IRCCS ״Burlo Garofolo”, Trieste, 34137, Italy
Igor Rudan
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK
Katherine S Ruth
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK
Danish Saleheen
Centre for Non-Communicable Diseases, Karachi, PakistanDepartment of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA
Veikko Salomaa
National Institute for Health and Welfare, Helsinki, FI-00271, Finland
Nilesh J Samani
Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UKNIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, LE3 9QP, UK
Pamela J Schreiner
Division of Epidemiology & Community Health University of Minnesota, Minneapolis, MN, 55454, USA
Matthias B Schulze
German Center for Diabetes Research, München-Neuherberg, 85764, GermanyDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam- Rehbruecke (DlfE), Nuthetal, 14558, Germany
Robert A Scott
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK
Marcelo P Segura-Lepe
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 IPG, UK
Xueling Sim
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Ml, 48109, USASaw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore 117549, Singapore
Andrew J Slater
Genetics, Target Sciences, GlaxoSmithKline, Research Triangle Park, NC, 27709, USOmicSoft a QIAGEN Company, Cary, NC, 27513, US
Kerrin S Small
Department of Twin Research and Genetic Epidemiology, King’s College London, London, SEI 7EH, UK
Blair H Smith
Division of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UKGeneration Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
Jennifer A Smith
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Ml, 48109, USA
Lorraine Southam
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UKWellcome Trust Sanger Institute, Hinxton, CB10 ISA, UK
Timothy D Spector
Department of Twin Research and Genetic Epidemiology, King’s College London, London, SEI 7EH, UK
Elizabeth K Speliotes
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Ml, 48109, USADepartment of Internal Medicine, University of Michigan, Ann Arbor, Ml, 48109, USADivision of Gastroenterology, University of Michigan, Ann Arbor, Ml, 48109, USA
Kari Stefansson
deCODE Genetics/Amgen inc., Reykjavik, 101, IcelandFaculty of Medicine, University of Iceland, Reykjavik, 101, Iceland
Valgerdur Steinthorsdottir
deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland
Kathleen E Stirrups
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UKDepartment of Haematology, University of Cambridge, Cambridge, CB2 OPT, UK
Konstantin Strauch
Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, GermanyChair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, 81377, Germany
Heather M Stringham
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Ml, 48109, USA
Michael Stumvoll
IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, GermanyUniversity of Leipzig, Department of Medicine, Leipzig, 04103, Germany
Liang Sun
Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708, USADepartment of Public Health, University of Helsinki, Helsinki, FI-00014, Finland
Praveen Surendran
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
Karin MA Swart
VU University Medical Center, Department of Epidemiology and Biostatistics, Amsterdam, 1007 MB, The Netherlands
Jean-Claude Tardif
Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, HIT 1C8, CanadaDepartment of Medicine, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada
Kent D Taylor
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA
Alexander Teumer
Institute for Community Medicine, University Medicine Greifswald, Greifswald, 17475, Germany
Deborah J Thompson
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
Gudmar Thorleifsson
deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland
Unnur Thorsteinsdottir
deCODE Genetics/Amgen inc., Reykjavik, 101, IcelandFaculty of Medicine, University of Iceland, Reykjavik, 101, Iceland
Betina H Thuesen
Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, Denmark
Anke Tönjes
Center for Pediatric Research, Department for Women’s and Child Health, University of Leipzig, Leipzig, 04103, Germany
Mina Torres
USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA
Emmanouil Tsafantakis
Anogia Medical Centre, Anogia, Greece
Jaakko Tuomilehto
National Institute for Health and Welfare, Helsinki, FI-00271, FinlandCentre for Vascular Prevention, Danube-University Krems, Krems, 3500, AustriaDasman Diabetes Institute, Dasman, 15462, KuwaitDiabetes Research Group, King Abdulaziz University, Jeddah, 21589, Saudi Arabia
André G Uitterlinden
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The NetherlandsDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Matti Uusitupa
Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70210, Finland
Cornelia M van Duijn
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Mauno Vanhala
Central Finland Central Hospital, Jyvaskyla, 40620, FinlandUniversity of Eastern Finland, Kuopio, 70210, Finland
Rohit Varma
USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA
Sita H Vermeulen
Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands
Henrik Vestergaard
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, DenmarkSteno Diabetes Center Copenhagen, Gentofte, 2800, Denmark
Veronique Vitart
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
Thomas F Vogt
Merck, Sharp & Dohme, Cardiometabolic Disease, Kenilworth, NJ, 07033, USA
Dragana Ntalla
Institute for Maternal and Child Health - IRCCS ״Burlo Garofolo”, Trieste, Italy
Lynne E Wagenknecht
Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA
Mark Walker
Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle, NE2 4HH, UK
Lars Wallentin
Department of Medical Sciences, Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, 752 37, Sweden
Feijie Wang
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People’s Republic of China, Shanghai, 200031, China
Carol A Wang
School of Women’s and Infants’ Health, The University of Western Australia, Perth, Western Australia, 6009, Australia
Shuai Wang
Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA
Nicholas J Wareham
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK
Helen R Warren
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UKNIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
Dawn M Waterworth
Genetics, Target Sciences, GlaxoSmithKline, King of Prussia, PA, US
Jennifer Wessel
Departments of Epidemiology & Medicine, Diabetes Translational Research Center, Fairbanks School of Public Health & School of Medicine, Indiana University, Indiana, IN, 46202, USA
Harvey D White
Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand
Cristen J Willer
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Ml, 48109, USADepartment of Internal Medicine, University of Michigan, Ann Arbor, Ml, 48109, USADepartment of Human Genetics, University of Michigan, Ann Arbor, Ml, 48109, USA
James G Wilson
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA
Andrew R Wood
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK
Ying Wu
Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA
Hanieh Yaghootkar
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK
Jie Yao
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA
Laura M Yerges-Armstrong
Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USGlaxoSmithKline, King of Prussia, PA, 19406, USA
Robin Young
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UKUniversity of Glasgow, Glasgow, G12 8QQ, UK
Eleftheria Zeggini
Wellcome Trust Sanger Institute, Hinxton, CB10 ISA, UK
Xiaowei Zhan
Department of Clinical Sciences, Quantitative Biomedical Research Center, Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA
Weihua Zhang
Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex, UB1 3HW, UKDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 IPG, UK
Jing Hua Zhao
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK
Wei Zhao
Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA
He Zheng
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People’s Republic of China, Shanghai, 200031, China
Wei Zhou
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Ml, 48109, USADepartment of Internal Medicine, University of Michigan, Ann Arbor, Ml, 48109, USA
M Carola Zillikens
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The NetherlandsDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Fernando Rivadeneira
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The NetherlandsDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Ingrid B Borecki
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St.Louis, MO, 63108, USA
John A Pospisilik
Max Planck Institute of Immunobiology and Epigenetics, Freiburg, 79108, Germany
Panos Deloukas
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UKPrincess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER- HD), King Abdulaziz University, Jeddah, 21589, Saudi Arabia
Timothy M Frayling
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK
Guillaume Lettre
Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, HIT 1C8, CanadaDepartment of Medicine, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada
Karen L Mohlke
Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA
Jerome I Rotter
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA
Zoltan Kutalik
Swiss Institute of Bioinformatics, Lausanne, 1015, SwitzerlandInstitute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, Switzerland
Joel N Hirschhorn
Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USADivision of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA, 02115, USADepartments of Pediatrics and Genetics, Harvard Medical School, Boston, MA, 02115, USA
L Adrienne Cupples
NHLBI Framingham Heart Study, Framingham, MA, 01702, USADepartment of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA
Ruth JF Loos
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USAThe Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USAThe Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA
Kari E North
Department of Epidemiology and Carolina Center of Genome Sciences, Chapel Hill, NC, 27514, USA
Cecilia M Lindgren
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UKBroad Institute of MIT and Harvard, Cambridge, MA, 02142, USALi Ka Shing Centre for Health Information and Discovery, The Big Data Institute, University of Oxford, Oxford, OX3 7BN, UK
ABSTRACT
Body fat distribution is a heritable risk factor for a range of adverse health consequences, including hyperlipidemia and type 2 diabetes. To identify protein-coding variants associated with body fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, we analyzed 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries for discovery and 132,177 independent European-ancestry individuals for validation. We identified 15 common (minor allele frequency, MAF≥5%) and 9 low frequency or rare (MAF<5%) coding variants that have not been reported previously. Pathway/gene set enrichment analyses of all associated variants highlight lipid particle, adiponectin level, abnormal white adipose tissue physiology, and bone development and morphology as processes affecting fat distribution and body shape. Furthermore, the cross-trait associations and the analyses of variant and gene function highlight a strong connection to lipids, cardiovascular traits, and type 2 diabetes. In functional follow-up analyses, specifically in Drosophila RNAi-knockdown crosses, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). By examining variants often poorly tagged or entirely missed by genome-wide association studies, we implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Posted June 30, 2018.
Protein-Coding Variants Implicate Novel Genes Related to Lipid Homeostasis Contributing to Body Fat Distribution
Anne E Justice, Tugce Karaderi, Heather M Highland, Kristin L Young, Mariaelisa Graff, Yingchang Lu, Valérie Turcot, Paul L Auer, Rebecca S Fine, Xiuqing Guo, Claudia Schurmann, Adelheid Lempradl, Eirini Marouli, Anubha Mahajan, Thomas W Winkler, Adam E Locke, Carolina Medina-Gomez, Tõnu Esko, Sailaja Vedantam, Ayush Giri, Ken Sin Lo, Tamuno Alfred, Poorva Mudgal, Maggie CY Ng, Nancy L Heard-Costa, Mary F Feitosa, Alisa K Manning, Sara M Willems, Suthesh Sivapalaratnam, Goncalo Abecasis, Dewan S Alam, Matthew Allison, Philippe Amouyel, Zorayr Arzumanyan, Beverley Balkau, Lisa Bastarache, Sven Bergmann, Lawrence F Bielak, Matthias Blüher, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Carsten A Boger, Jette Bork-Jensen, Erwin P Bottinger, Donald W Bowden, Ivan Brandslund, Linda Broer, Amber A Burt, Adam S Butterworth, Mark J Caulfield, Giancarlo Cesana, John C Chambers, Daniel I Chasman, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, Francis S Collins, James P Cook, Amanda J Cox, David S Crosslin, John Danesh, Paul IW de Bakker, Simon de Denus, Renee de Mutsert, George Dedoussis, Ellen W Demerath, Joe G Dennis, Josh C Denny, Emanuele Di Angelantonio, Marcus Dorr, Fotios Drenos, Marie-Pierre Dube, Alison M Dunning, Douglas F Easton, Paul Elliott, Evangelos Evangelou, Aliki-Eleni Farmaki, Shuang Feng, Ele Ferrannini, Jean Ferrieres, Jose C Florez, Myriam Fornage, Caroline S Fox, Paul W Franks, Nele Friedrich, Wei Gan, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Giorgia Girotto, Mathias Gorski, Harald Grallert, Niels Grarup, Megan L Grove, Stefan Gustafsson, Jeff Haessler, Torben Hansen, Andrew T Hattersley, Caroline Hayward, Iris M Heid, Oddgeir L Holmen, G Kees Hovingh, Joanna MM Howson, Yao Hu, Yi-Jen Hung, Kristian Hveem, M Arfan Ikram, Erik Ingelsson, Anne U Jackson, Gail P Jarvik, Yucheng Jia, Torben Jørgensen, Pekka Jousilahti, Johanne M Justesen, Bratati Kahali, Maria Karaleftheri, Sharon LR Kardia, Fredrik Karpe, Frank Kee, Hidetoshi Kitajima, Pirjo Komulainen, Jaspal S Kooner, Peter Kovacs, Bernhard K Kramer, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo A Lakka, David Lamparter, Leslie A Lange, Claudia Langenberg, Eric B Larson, Nanette R Lee, Wen-Jane Lee, Terho Lehtimäki, Cora E Lewis, Huaixing Li, Jin Li, Ruifang Li-Gao, Li-An Lin, Xu Lin, Lars Lind, Jaana Lindström, Allan Linneberg, Ching-Ti Liu, Dajiang J Liu, Jian’an Luan, Leo-Pekka Lyytikäinen, Stuart MacGregor, Reedik Mägi, Satu Männistö, Gaëlle Marenne, Jonathan Marten, Nicholas GD Masca, Mark I McCarthy, Karina Meidtner, Evelin Mihailov, Leena Moilanen, Marie Moitry, Dennis O Mook-Kanamori, Anna Morgan, Andrew P Morris, Martina Muller-Nurasyid, Patricia B Munroe, Narisu Narisu, Christopher P Nelson, Matt Neville, Ioanna Ntalla, Jeffrey R O’Connel, Katharine R Owen, Oluf Pedersen, Gina M Peloso, Craig E Pennell, Markus Perola, James A Perry, John RB Perry, Tune H Pers, Ailith Pirie, Ozren Polasek, Olli T Raitakari, Asif Rasheed, Chelsea K Raulerson, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Paul M Ridker, Manuel A Rivas, Neil R Robertson, Antonietta Robino, Igor Rudan, Katherine S Ruth, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Pamela J Schreiner, Matthias B Schulze, Robert A Scott, Marcelo P Segura-Lepe, Xueling Sim, Andrew J Slater, Kerrin S Small, Blair H Smith, Jennifer A Smith, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, Kari Stefansson, Valgerdur Steinthorsdottir, Kathleen E Stirrups, Konstantin Strauch, Heather M Stringham, Michael Stumvoll, Liang Sun, Praveen Surendran, Karin MA Swart, Jean-Claude Tardif, Kent D Taylor, Alexander Teumer, Deborah J Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Betina H Thuesen, Anke Tönjes, Mina Torres, Emmanouil Tsafantakis, Jaakko Tuomilehto, André G Uitterlinden, Matti Uusitupa, Cornelia M van Duijn, Mauno Vanhala, Rohit Varma, Sita H Vermeulen, Henrik Vestergaard, Veronique Vitart, Thomas F Vogt, Dragana Ntalla, Lynne E Wagenknecht, Mark Walker, Lars Wallentin, Feijie Wang, Carol A Wang, Shuai Wang, Nicholas J Wareham, Helen R Warren, Dawn M Waterworth, Jennifer Wessel, Harvey D White, Cristen J Willer, James G Wilson, Andrew R Wood, Ying Wu, Hanieh Yaghootkar, Jie Yao, Laura M Yerges-Armstrong, Robin Young, Eleftheria Zeggini, Xiaowei Zhan, Weihua Zhang, Jing Hua Zhao, Wei Zhao, He Zheng, Wei Zhou, M Carola Zillikens, GoT2D Genes Consortium CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Fernando Rivadeneira, Ingrid B Borecki, John A Pospisilik, Panos Deloukas, Timothy M Frayling, Guillaume Lettre, Karen L Mohlke, Jerome I Rotter, Zoltan Kutalik, Joel N Hirschhorn, L Adrienne Cupples, Ruth JF Loos, Kari E North, Cecilia M Lindgren
bioRxiv 352674; doi: https://doi.org/10.1101/352674
Protein-Coding Variants Implicate Novel Genes Related to Lipid Homeostasis Contributing to Body Fat Distribution
Anne E Justice, Tugce Karaderi, Heather M Highland, Kristin L Young, Mariaelisa Graff, Yingchang Lu, Valérie Turcot, Paul L Auer, Rebecca S Fine, Xiuqing Guo, Claudia Schurmann, Adelheid Lempradl, Eirini Marouli, Anubha Mahajan, Thomas W Winkler, Adam E Locke, Carolina Medina-Gomez, Tõnu Esko, Sailaja Vedantam, Ayush Giri, Ken Sin Lo, Tamuno Alfred, Poorva Mudgal, Maggie CY Ng, Nancy L Heard-Costa, Mary F Feitosa, Alisa K Manning, Sara M Willems, Suthesh Sivapalaratnam, Goncalo Abecasis, Dewan S Alam, Matthew Allison, Philippe Amouyel, Zorayr Arzumanyan, Beverley Balkau, Lisa Bastarache, Sven Bergmann, Lawrence F Bielak, Matthias Blüher, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Carsten A Boger, Jette Bork-Jensen, Erwin P Bottinger, Donald W Bowden, Ivan Brandslund, Linda Broer, Amber A Burt, Adam S Butterworth, Mark J Caulfield, Giancarlo Cesana, John C Chambers, Daniel I Chasman, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, Francis S Collins, James P Cook, Amanda J Cox, David S Crosslin, John Danesh, Paul IW de Bakker, Simon de Denus, Renee de Mutsert, George Dedoussis, Ellen W Demerath, Joe G Dennis, Josh C Denny, Emanuele Di Angelantonio, Marcus Dorr, Fotios Drenos, Marie-Pierre Dube, Alison M Dunning, Douglas F Easton, Paul Elliott, Evangelos Evangelou, Aliki-Eleni Farmaki, Shuang Feng, Ele Ferrannini, Jean Ferrieres, Jose C Florez, Myriam Fornage, Caroline S Fox, Paul W Franks, Nele Friedrich, Wei Gan, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Giorgia Girotto, Mathias Gorski, Harald Grallert, Niels Grarup, Megan L Grove, Stefan Gustafsson, Jeff Haessler, Torben Hansen, Andrew T Hattersley, Caroline Hayward, Iris M Heid, Oddgeir L Holmen, G Kees Hovingh, Joanna MM Howson, Yao Hu, Yi-Jen Hung, Kristian Hveem, M Arfan Ikram, Erik Ingelsson, Anne U Jackson, Gail P Jarvik, Yucheng Jia, Torben Jørgensen, Pekka Jousilahti, Johanne M Justesen, Bratati Kahali, Maria Karaleftheri, Sharon LR Kardia, Fredrik Karpe, Frank Kee, Hidetoshi Kitajima, Pirjo Komulainen, Jaspal S Kooner, Peter Kovacs, Bernhard K Kramer, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo A Lakka, David Lamparter, Leslie A Lange, Claudia Langenberg, Eric B Larson, Nanette R Lee, Wen-Jane Lee, Terho Lehtimäki, Cora E Lewis, Huaixing Li, Jin Li, Ruifang Li-Gao, Li-An Lin, Xu Lin, Lars Lind, Jaana Lindström, Allan Linneberg, Ching-Ti Liu, Dajiang J Liu, Jian’an Luan, Leo-Pekka Lyytikäinen, Stuart MacGregor, Reedik Mägi, Satu Männistö, Gaëlle Marenne, Jonathan Marten, Nicholas GD Masca, Mark I McCarthy, Karina Meidtner, Evelin Mihailov, Leena Moilanen, Marie Moitry, Dennis O Mook-Kanamori, Anna Morgan, Andrew P Morris, Martina Muller-Nurasyid, Patricia B Munroe, Narisu Narisu, Christopher P Nelson, Matt Neville, Ioanna Ntalla, Jeffrey R O’Connel, Katharine R Owen, Oluf Pedersen, Gina M Peloso, Craig E Pennell, Markus Perola, James A Perry, John RB Perry, Tune H Pers, Ailith Pirie, Ozren Polasek, Olli T Raitakari, Asif Rasheed, Chelsea K Raulerson, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Paul M Ridker, Manuel A Rivas, Neil R Robertson, Antonietta Robino, Igor Rudan, Katherine S Ruth, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Pamela J Schreiner, Matthias B Schulze, Robert A Scott, Marcelo P Segura-Lepe, Xueling Sim, Andrew J Slater, Kerrin S Small, Blair H Smith, Jennifer A Smith, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, Kari Stefansson, Valgerdur Steinthorsdottir, Kathleen E Stirrups, Konstantin Strauch, Heather M Stringham, Michael Stumvoll, Liang Sun, Praveen Surendran, Karin MA Swart, Jean-Claude Tardif, Kent D Taylor, Alexander Teumer, Deborah J Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Betina H Thuesen, Anke Tönjes, Mina Torres, Emmanouil Tsafantakis, Jaakko Tuomilehto, André G Uitterlinden, Matti Uusitupa, Cornelia M van Duijn, Mauno Vanhala, Rohit Varma, Sita H Vermeulen, Henrik Vestergaard, Veronique Vitart, Thomas F Vogt, Dragana Ntalla, Lynne E Wagenknecht, Mark Walker, Lars Wallentin, Feijie Wang, Carol A Wang, Shuai Wang, Nicholas J Wareham, Helen R Warren, Dawn M Waterworth, Jennifer Wessel, Harvey D White, Cristen J Willer, James G Wilson, Andrew R Wood, Ying Wu, Hanieh Yaghootkar, Jie Yao, Laura M Yerges-Armstrong, Robin Young, Eleftheria Zeggini, Xiaowei Zhan, Weihua Zhang, Jing Hua Zhao, Wei Zhao, He Zheng, Wei Zhou, M Carola Zillikens, GoT2D Genes Consortium CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Fernando Rivadeneira, Ingrid B Borecki, John A Pospisilik, Panos Deloukas, Timothy M Frayling, Guillaume Lettre, Karen L Mohlke, Jerome I Rotter, Zoltan Kutalik, Joel N Hirschhorn, L Adrienne Cupples, Ruth JF Loos, Kari E North, Cecilia M Lindgren
bioRxiv 352674; doi: https://doi.org/10.1101/352674
Subject Area
Subject Areas
- Biochemistry (2205)
- Bioengineering (1518)
- Bioinformatics (8897)
- Biophysics (3495)
- Cancer Biology (2619)
- Cell Biology (3703)
- Clinical Trials (134)
- Developmental Biology (2353)
- Ecology (3660)
- Epidemiology (2011)
- Evolutionary Biology (6353)
- Genetics (4737)
- Genomics (5960)
- Immunology (1876)
- Microbiology (6190)
- Molecular Biology (2388)
- Neuroscience (15291)
- Paleontology (107)
- Pathology (368)
- Physiology (913)
- Plant Biology (2155)
- Synthetic Biology (752)
- Systems Biology (2468)
- Zoology (378)