New Results
Protein-Coding Variants Implicate Novel Genes Related to Lipid Homeostasis Contributing to Body Fat Distribution
Anne E Justice, Tugce Karaderi, Heather M Highland, Kristin L Young, Mariaelisa Graff, Yingchang Lu, Valérie Turcot, Paul L Auer, Rebecca S Fine, Xiuqing Guo, Claudia Schurmann, Adelheid Lempradl, Eirini Marouli, Anubha Mahajan, Thomas W Winkler, Adam E Locke, Carolina Medina-Gomez, Tõnu Esko, Sailaja Vedantam, Ayush Giri, Ken Sin Lo, Tamuno Alfred, Poorva Mudgal, Maggie CY Ng, Nancy L Heard-Costa, Mary F Feitosa, Alisa K Manning, Sara M Willems, Suthesh Sivapalaratnam, Goncalo Abecasis, Dewan S Alam, Matthew Allison, Philippe Amouyel, Zorayr Arzumanyan, Beverley Balkau, Lisa Bastarache, Sven Bergmann, Lawrence F Bielak, Matthias Blüher, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Carsten A Boger, Jette Bork-Jensen, Erwin P Bottinger, Donald W Bowden, Ivan Brandslund, Linda Broer, Amber A Burt, Adam S Butterworth, Mark J Caulfield, Giancarlo Cesana, John C Chambers, Daniel I Chasman, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, Francis S Collins, James P Cook, Amanda J Cox, David S Crosslin, John Danesh, Paul IW de Bakker, Simon de Denus, Renee de Mutsert, George Dedoussis, Ellen W Demerath, Joe G Dennis, Josh C Denny, Emanuele Di Angelantonio, Marcus Dorr, Fotios Drenos, Marie-Pierre Dube, Alison M Dunning, Douglas F Easton, Paul Elliott, Evangelos Evangelou, Aliki-Eleni Farmaki, Shuang Feng, Ele Ferrannini, Jean Ferrieres, Jose C Florez, Myriam Fornage, Caroline S Fox, Paul W Franks, Nele Friedrich, Wei Gan, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Giorgia Girotto, Mathias Gorski, Harald Grallert, Niels Grarup, Megan L Grove, Stefan Gustafsson, Jeff Haessler, Torben Hansen, Andrew T Hattersley, Caroline Hayward, Iris M Heid, Oddgeir L Holmen, G Kees Hovingh, Joanna MM Howson, Yao Hu, Yi-Jen Hung, Kristian Hveem, M Arfan Ikram, Erik Ingelsson, Anne U Jackson, Gail P Jarvik, Yucheng Jia, Torben Jørgensen, Pekka Jousilahti, Johanne M Justesen, Bratati Kahali, Maria Karaleftheri, Sharon LR Kardia, Fredrik Karpe, Frank Kee, Hidetoshi Kitajima, Pirjo Komulainen, Jaspal S Kooner, Peter Kovacs, Bernhard K Kramer, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo A Lakka, David Lamparter, Leslie A Lange, Claudia Langenberg, Eric B Larson, Nanette R Lee, Wen-Jane Lee, Terho Lehtimäki, Cora E Lewis, Huaixing Li, Jin Li, Ruifang Li-Gao, Li-An Lin, Xu Lin, Lars Lind, Jaana Lindström, Allan Linneberg, Ching-Ti Liu, Dajiang J Liu, Jian’an Luan, Leo-Pekka Lyytikäinen, Stuart MacGregor, Reedik Mägi, Satu Männistö, Gaëlle Marenne, Jonathan Marten, Nicholas GD Masca, Mark I McCarthy, Karina Meidtner, Evelin Mihailov, Leena Moilanen, Marie Moitry, Dennis O Mook-Kanamori, Anna Morgan, Andrew P Morris, Martina Muller-Nurasyid, Patricia B Munroe, Narisu Narisu, Christopher P Nelson, Matt Neville, Ioanna Ntalla, Jeffrey R O’Connel, Katharine R Owen, Oluf Pedersen, Gina M Peloso, Craig E Pennell, Markus Perola, James A Perry, John RB Perry, Tune H Pers, Ailith Pirie, Ozren Polasek, Olli T Raitakari, Asif Rasheed, Chelsea K Raulerson, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Paul M Ridker, Manuel A Rivas, Neil R Robertson, Antonietta Robino, Igor Rudan, Katherine S Ruth, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Pamela J Schreiner, Matthias B Schulze, Robert A Scott, Marcelo P Segura-Lepe, Xueling Sim, Andrew J Slater, Kerrin S Small, Blair H Smith, Jennifer A Smith, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, Kari Stefansson, Valgerdur Steinthorsdottir, Kathleen E Stirrups, Konstantin Strauch, Heather M Stringham, Michael Stumvoll, Liang Sun, Praveen Surendran, Karin MA Swart, Jean-Claude Tardif, Kent D Taylor, Alexander Teumer, Deborah J Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Betina H Thuesen, Anke Tönjes, Mina Torres, Emmanouil Tsafantakis, Jaakko Tuomilehto, André G Uitterlinden, Matti Uusitupa, Cornelia M van Duijn, Mauno Vanhala, Rohit Varma, Sita H Vermeulen, Henrik Vestergaard, Veronique Vitart, Thomas F Vogt, Dragana Ntalla, Lynne E Wagenknecht, Mark Walker, Lars Wallentin, Feijie Wang, Carol A Wang, Shuai Wang, Nicholas J Wareham, Helen R Warren, Dawn M Waterworth, Jennifer Wessel, Harvey D White, Cristen J Willer, James G Wilson, Andrew R Wood, Ying Wu, Hanieh Yaghootkar, Jie Yao, Laura M Yerges-Armstrong, Robin Young, Eleftheria Zeggini, Xiaowei Zhan, Weihua Zhang, Jing Hua Zhao, Wei Zhao, He Zheng, Wei Zhou, M Carola Zillikens, GoT2D Genes Consortium CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Fernando Rivadeneira, Ingrid B Borecki, John A Pospisilik, Panos Deloukas, Timothy M Frayling, Guillaume Lettre, Karen L Mohlke, Jerome I Rotter, Zoltan Kutalik, Joel N Hirschhorn, L Adrienne Cupples, Ruth JF Loos, Kari E North, Cecilia M Lindgren
doi: https://doi.org/10.1101/352674
Anne E Justice
1Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27514, USA
2Biomedical and Translational Informatics, Geisinger Health, Danville, PA 17822
Tugce Karaderi
3Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UK
4Department of Biological Sciences, Faculty of Arts and Sciences, Eastern Mediterranean University, Famagusta, Cyprus
Heather M Highland
1Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27514, USA
5Human Genetics Center, The University of Texas School of Public Health, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA
Kristin L Young
1Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27514, USA
Mariaelisa Graff
1Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27514, USA
Yingchang Lu
6Division of Epidemiology, Department of Medicine, Vanderbilt-lngram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, 37203, USA
7The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA
8The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA
Valérie Turcot
9Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, HIT 1C8, Canada
Paul L Auer
10Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wl, 53201, USA
Rebecca S Fine
11Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
12Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA
13Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA, 02115, USA
Xiuqing Guo
14Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA
Claudia Schurmann
7The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA
8The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA
Adelheid Lempradl
15Max Planck Institute of Immunobiology and Epigenetics, Freiburg, 79108, Germany
Eirini Marouli
16William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
Anubha Mahajan
3Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UK
Thomas W Winkler
17Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, Germany
Adam E Locke
18Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Ml, 48109, USA
19McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO, 63108, USA
Carolina Medina-Gomez
20Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
21Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Tõnu Esko
11Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
13Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA, 02115, USA
22Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia
Sailaja Vedantam
11Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
12Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA
13Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA, 02115, USA
Ayush Giri
23Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, 37203, USA
Ken Sin Lo
9Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, HIT 1C8, Canada
Tamuno Alfred
7The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA
Poorva Mudgal
24Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA
Maggie CY Ng
24Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA
25Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA
Nancy L Heard-Costa
26Department of Neurology, Boston University School of Medicine, Boston, MA, 02118, USA
27NHLBI Framingham Heart Study, Framingham, MA, 01702, USA
Mary F Feitosa
28Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St.Louis, MO, 63108, USA
Alisa K Manning
11Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
29Department of Medicine, Harvard University Medical School, Boston, MA, 02115, USA
30Massachusetts General Hospital, Boston, MA, 02114, USA
Sara M Willems
31MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK
Suthesh Sivapalaratnam
30Massachusetts General Hospital, Boston, MA, 02114, USA
32Department of Vascular Medicine, AMC, Amsterdam, 1105 AZ, The Netherlands
33Department of Haematology, University of Cambridge, Cambridge, CB2 OPT, UK
Goncalo Abecasis
18Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Ml, 48109, USA
Dewan S Alam
34School of Kinesiology and Health Science, Faculty of Health, York University, Toronto
Matthew Allison
35Department of Family Medicine & Public Health, University of California, San Diego, La Jolla, CA, 92093, USA
Philippe Amouyel
36INSERM U1167, Lille, F-59019, France
37Institut Pasteur de Lille, U1167, Lille, F-59019, France
38Universite de Lille, U1167 - RID-AGE - Risk factors and molecular determinants of aging-related diseases, Lille, F-59019, France
Zorayr Arzumanyan
14Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA
Beverley Balkau
39INSERM U1018, Centre de recherche en Epidemiologie et Santé des Populations (CESP), Villejuif, France
Lisa Bastarache
40Department of Biomedical Informaties, Vanderbilt University, Nashville, TN, 37203, USA
Sven Bergmann
41Department of Computational Biology, University of Lausanne, Lausanne, 1011, Switzerland
42Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland
Lawrence F Bielak
43Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Ml, 48109, USA
Matthias Blüher
44IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany
45University of Leipzig, Department of Medicine, Leipzig, 04103, Germany
Michael Boehnke
18Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Ml, 48109, USA
Heiner Boeing
46Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DlfE), Nuthetal, 14558, Germany
Eric Boerwinkle
47School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA
48Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, 77030 USA
Carsten A Boger
49Department of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany
Jette Bork-Jensen
50The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark
Erwin P Bottinger
7The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA
Donald W Bowden
24Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA
25Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA
51Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA
Ivan Brandslund
52Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, 7100, Denmark
53Institute of Regional Health Research, University of Southern Denmark, Odense, 5000, Denmark
Linda Broer
21Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Amber A Burt
54Department of Medicine, University of Washington, Seattle, WA, 98195, USA
Adam S Butterworth
55MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
56NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
Mark J Caulfield
16William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
57NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
Giancarlo Cesana
58Research Centre on Public Health, University of Milano-Bicocca, Monza, 20900, Italy
John C Chambers
59Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore
60Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex, UB1 3HW, UK
61Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 IPG, UK
62Imperial College Healthcare NHS Trust, London, W12 OHS, UK
63MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 IPG, UK
Daniel I Chasman
11Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
64Division of Genetics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 02115, USA
65Division of Preventive Medicine, Brigham and Women’s and Harvard Medical School, Boston, MA, 02215, USA
66Harvard Medical School, Boston, MA, 02115, USA
Yii-Der Ida Chen
14Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA
Rajiv Chowdhury
55MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
Cramer Christensen
67Medical department, Lillebaelt Hospital, Vejle, 7100, Denmark
Audrey Y Chu
27NHLBI Framingham Heart Study, Framingham, MA, 01702, USA
65Division of Preventive Medicine, Brigham and Women’s and Harvard Medical School, Boston, MA, 02215, USA
Francis S Collins
68Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA
James P Cook
69Department of Biostatistics, University of Liverpool, Liverpool, L69 3GL, UK
Amanda J Cox
24Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA
25Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA
70Menzies Health Institute Queensland, Griffith University, Southport, QLD, Australia
David S Crosslin
71Department of Biomedical Infomatics and Medical Education, University of Washington, Seattle, WA, 98195, USA
John Danesh
55MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
56NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
72Wellcome Trust Sanger Institute, Hinxton, CB10 ISA, UK
73British Heart Foundation Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK
Paul IW de Bakker
74Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
75Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
Simon de Denus
9Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, HIT 1C8, Canada
76Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada
Renee de Mutsert
77Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands
George Dedoussis
78Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece
Ellen W Demerath
79Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55454, USA
Joe G Dennis
80Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
Josh C Denny
40Department of Biomedical Informaties, Vanderbilt University, Nashville, TN, 37203, USA
Emanuele Di Angelantonio
55MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
56NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
Marcus Dorr
81Department of Internal Medicine B, University Medicine Greifswald, Greifswald, 17475, Germany
82DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany
Fotios Drenos
83Institute of Cardiovascular Science, University College London, London, WC1E 6JF, UK
84MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, UK
Marie-Pierre Dube
9Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, HIT 1C8, Canada
85Department of Medicine, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada
Alison M Dunning
86Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK
Douglas F Easton
80Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
86Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK
Paul Elliott
87Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, W2 IPG, UK
Evangelos Evangelou
61Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 IPG, UK
88Department of Hygiene and Epidemiology, University of loannina Medical School, loannina, 45110, Greece
Aliki-Eleni Farmaki
78Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece
Shuang Feng
18Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Ml, 48109, USA
Ele Ferrannini
89CNR Institute of Clinical Physiology, Pisa, Italy
90Department of Clinical & Experimental Medicine, University of Pisa, Italy
Jean Ferrieres
91Toulouse University School of Medicine, Toulouse, TSA 50032 31059, France
Jose C Florez
11Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
29Department of Medicine, Harvard University Medical School, Boston, MA, 02115, USA
30Massachusetts General Hospital, Boston, MA, 02114, USA
Myriam Fornage
92Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA
Caroline S Fox
27NHLBI Framingham Heart Study, Framingham, MA, 01702, USA
Paul W Franks
93Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, SE-20502, Sweden
94Department of Nutrition, Harvard School of Public Health, Boston, MA, 02115, USA
95Department of Public Health and Clinical Medicine, Unit of Medicine, Umeâ University, Umeâ, 901 87, Sweden
Nele Friedrich
96Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, 17475, Germany
Wei Gan
3Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UK
Ilaria Gandin
97Ilaria Gandin, Research Unit, AREA Science Park, Trieste, 34149, Italy
Paolo Gasparini
98Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy
99Institute for Maternal and Child Health - IRCCS ״Burlo Garofolo”, Trieste, Italy
Vilmantas Giedraitis
100Geriatrics, Department of Public Health, Uppsala University, Uppsala, 751 85, Sweden
Giorgia Girotto
98Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy
99Institute for Maternal and Child Health - IRCCS ״Burlo Garofolo”, Trieste, Italy
Mathias Gorski
17Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, Germany
49Department of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany
Harald Grallert
101German Center for Diabetes Research, München-Neuherberg, 85764, Germany
102Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany
103Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany
Niels Grarup
50The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark
Megan L Grove
47School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA
Stefan Gustafsson
104Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, 751 41, Sweden
Jeff Haessler
105Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle WA, 98109, USA
Torben Hansen
50The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark
Andrew T Hattersley
106University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK
Caroline Hayward
107MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
Iris M Heid
17Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, Germany
108Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany
Oddgeir L Holmen
109K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, NTNU, Norwegian University of Science and Technology, Trondheim, 7600, Norway
G Kees Hovingh
110AMC, Department of Vascular Medicine, Amsterdam, 1105 AZ, The Netherlands
Joanna MM Howson
55MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
Yao Hu
111Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People’s Republic of China, Shanghai, 200031, China
Yi-Jen Hung
112Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan 114, Taiwan
113School of Medicine, National Defense Medical Center, Taipei, Taiwan 114, Taiwan
Kristian Hveem
109K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, NTNU, Norwegian University of Science and Technology, Trondheim, 7600, Norway
114HUNT Research center, Department of Public Health, Norwegian University of Science and Technology, Levanger, 7600, Norway
M Arfan Ikram
20Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
115Department of Neurology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
116Department of Radiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Erik Ingelsson
104Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, 751 41, Sweden
117Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 943 05, USA
Anne U Jackson
18Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Ml, 48109, USA
Gail P Jarvik
54Department of Medicine, University of Washington, Seattle, WA, 98195, USA
118Department of Genome Sciences, University of Washington, Seattle, WA, 98195, USA
Yucheng Jia
14Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA
Torben Jørgensen
119Faculty of medicine, Aalborg University, Aalborg, DK-9000, Denmark
120Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark
121Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, Denmark
Pekka Jousilahti
122National Institute for Health and Welfare, Helsinki, FI-00271, Finland
Johanne M Justesen
50The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark
Bratati Kahali
123Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Ml, 48109, USA
124Department of Internal Medicine, University of Michigan, Ann Arbor, Ml, 48109, USA
125Division of Gastroenterology, University of Michigan, Ann Arbor, Ml, 48109, USA
126Centre for Brain Research, Indian Institute of Science, Bangalore 560012, India
Maria Karaleftheri
127Echinos Medical Centre, Echinos, Greece
Sharon LR Kardia
43Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Ml, 48109, USA
Fredrik Karpe
128Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UK
129Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, OX3 7LE, UK
Frank Kee
130UKCRC Centre of Excellence for Public Health Research, Queens University Belfast, Belfast, UK, BT12 6BJ, UK
Hidetoshi Kitajima
3Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UK
Pirjo Komulainen
131Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland
132Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, 70210, Finland
133Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
Jaspal S Kooner
60Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex, UB1 3HW, UK
62Imperial College Healthcare NHS Trust, London, W12 OHS, UK
63MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 IPG, UK
134National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, London, W12 ONN, UK
Peter Kovacs
44IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany
Bernhard K Kramer
135University Medical Centre Mannheim, 5th Medical Department, University of Heidelberg, Mannheim, 68167, Germany
Kari Kuulasmaa
122National Institute for Health and Welfare, Helsinki, FI-00271, Finland
Johanna Kuusisto
136Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland
Markku Laakso
136Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland
Timo A Lakka
131Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland
132Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, 70210, Finland
133Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
David Lamparter
41Department of Computational Biology, University of Lausanne, Lausanne, 1011, Switzerland
42Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland
Leslie A Lange
137Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA
Claudia Langenberg
31MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK
Eric B Larson
54Department of Medicine, University of Washington, Seattle, WA, 98195, USA
138Kaiser Permanente Washington Health Research Institute Seattle WA 98101
139Department of Health Services, University of Washington, Seattle WA 98101
Nanette R Lee
140Department of Anthropology, Sociology, and History, University of San Carlos, Cebu City, 6000, Philippines
141USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, 6000, Philippines
Wen-Jane Lee
142Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan 407, Taiwan
143Department of Social Work, Tunghai University, Taichung, Taiwan
Terho Lehtimäki
144Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33521, Finland
145Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland
Cora E Lewis
146Division of Preventive Medicine University of Alabama at Birmingham, Birmingham, AL 35205, USA
Huaixing Li
111Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People’s Republic of China, Shanghai, 200031, China
Jin Li
147Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Palo Alto, CA, 94304, USA
Ruifang Li-Gao
77Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands
Li-An Lin
92Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA
Xu Lin
111Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People’s Republic of China, Shanghai, 200031, China
Lars Lind
148Uppsala University, Uppsala, 75185, Sweden
Jaana Lindström
122National Institute for Health and Welfare, Helsinki, FI-00271, Finland
Allan Linneberg
121Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, Denmark
149Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, DK-2200, Denmark
150Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark
Ching-Ti Liu
151Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA
Dajiang J Liu
152Department of Public Health Sciences, Institute for Personalized Medicine, the Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA
Jian’an Luan
31MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK
Leo-Pekka Lyytikäinen
144Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33521, Finland
145Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland
Stuart MacGregor
153QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia
Reedik Mägi
22Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia
Satu Männistö
122National Institute for Health and Welfare, Helsinki, FI-00271, Finland
Gaëlle Marenne
72Wellcome Trust Sanger Institute, Hinxton, CB10 ISA, UK
Jonathan Marten
107MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
Nicholas GD Masca
154Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK
155NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, LE3 9QP, UK
Mark I McCarthy
3Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UK
128Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UK
129Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, OX3 7LE, UK
Karina Meidtner
101German Center for Diabetes Research, München-Neuherberg, 85764, Germany
156Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam- Rehbruecke (DlfE), Nuthetal, 14558, Germany
Evelin Mihailov
22Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia
Leena Moilanen
157Department of Medicine, Kuopio University Hospital, Kuopio, 70210, Finland
Marie Moitry
158Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, F-67085, France
159Department of Public Health, University Hospital of Strasbourg, Strasbourg, F-67081, France
Dennis O Mook-Kanamori
77Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands
160Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2300RC, The Netherlands
Anna Morgan
98Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy
Andrew P Morris
3Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UK
69Department of Biostatistics, University of Liverpool, Liverpool, L69 3GL, UK
Martina Muller-Nurasyid
108Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany
161Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universitat, Munich, 81377, Germany
162DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, 80802, Germany
Patricia B Munroe
16William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
57NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
Narisu Narisu
68Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA
Christopher P Nelson
154Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK
155NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, LE3 9QP, UK
Matt Neville
128Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UK
129Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, OX3 7LE, UK
Ioanna Ntalla
16William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
Jeffrey R O’Connel
163Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, US
Katharine R Owen
128Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UK
129Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, OX3 7LE, UK
Oluf Pedersen
50The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark
Gina M Peloso
151Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA
Craig E Pennell
164School of Women’s and Infants’ Health, The University of Western Australia, Perth, Western Australia, 6009, Australia
Markus Perola
122National Institute for Health and Welfare, Helsinki, FI-00271, Finland
165University of Helsinki, Institute for Molecular Medicine (FIMM) and Diabetes and Obesity Research Program, Helsinki, FI00014, Finland
166University of Tartu, Estonian Genome Center, Tartu, Estonia, Tartu, 51010, Estonia
James A Perry
163Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, US
John RB Perry
31MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK
Tune H Pers
50The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark
167Department of Epidemiology Research, Statens Serum Institut, Copenhagen, 2200, Denmark
Ailith Pirie
86Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK
Ozren Polasek
168School of Medicine, University of Split, Split, 21000, Croatia
169Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK
Olli T Raitakari
170Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20521, Finland
171Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland
Asif Rasheed
172Centre for Non-Communicable Diseases, Karachi, Pakistan
Chelsea K Raulerson
137Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA
Rainer Rauramaa
131Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland
132Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, 70210, Finland
133Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
Dermot F Reilly
173Merck, Sharp & Dohme, Genetics and Pharmacogenomics, Boston, MA, 02115, USA
Alex P Reiner
105Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle WA, 98109, USA
174Department of Epidemiology, University of Washington, Seattle, WA, 98195, USA
Paul M Ridker
65Division of Preventive Medicine, Brigham and Women’s and Harvard Medical School, Boston, MA, 02215, USA
66Harvard Medical School, Boston, MA, 02115, USA
175Division of Cardiovascular Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 02115, USA
Manuel A Rivas
11Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
176Nuffield Department of Clinical Medicine, Oxford, 0X37 BN, UK
Neil R Robertson
3Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UK
128Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UK
Antonietta Robino
177Institute for Maternal and Child Health - IRCCS ״Burlo Garofolo”, Trieste, 34137, Italy
Igor Rudan
169Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK
Katherine S Ruth
178Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK
Danish Saleheen
172Centre for Non-Communicable Diseases, Karachi, Pakistan
179Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA
Veikko Salomaa
122National Institute for Health and Welfare, Helsinki, FI-00271, Finland
Nilesh J Samani
154Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK
155NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, LE3 9QP, UK
Pamela J Schreiner
180Division of Epidemiology & Community Health University of Minnesota, Minneapolis, MN, 55454, USA
Matthias B Schulze
101German Center for Diabetes Research, München-Neuherberg, 85764, Germany
156Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam- Rehbruecke (DlfE), Nuthetal, 14558, Germany
Robert A Scott
31MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK
Marcelo P Segura-Lepe
61Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 IPG, UK
Xueling Sim
18Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Ml, 48109, USA
181Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore 117549, Singapore
Andrew J Slater
182Genetics, Target Sciences, GlaxoSmithKline, Research Triangle Park, NC, 27709, US
183OmicSoft a QIAGEN Company, Cary, NC, 27513, US
Kerrin S Small
184Department of Twin Research and Genetic Epidemiology, King’s College London, London, SEI 7EH, UK
Blair H Smith
185Division of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
186Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
Jennifer A Smith
43Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Ml, 48109, USA
Lorraine Southam
3Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UK
72Wellcome Trust Sanger Institute, Hinxton, CB10 ISA, UK
Timothy D Spector
184Department of Twin Research and Genetic Epidemiology, King’s College London, London, SEI 7EH, UK
Elizabeth K Speliotes
123Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Ml, 48109, USA
124Department of Internal Medicine, University of Michigan, Ann Arbor, Ml, 48109, USA
125Division of Gastroenterology, University of Michigan, Ann Arbor, Ml, 48109, USA
Kari Stefansson
187deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland
188Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland
Valgerdur Steinthorsdottir
187deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland
Kathleen E Stirrups
16William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
33Department of Haematology, University of Cambridge, Cambridge, CB2 OPT, UK
Konstantin Strauch
108Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany
189Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, 81377, Germany
Heather M Stringham
18Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Ml, 48109, USA
Michael Stumvoll
44IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany
45University of Leipzig, Department of Medicine, Leipzig, 04103, Germany
Liang Sun
190Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708, USA
191Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland
Praveen Surendran
55MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
Karin MA Swart
192VU University Medical Center, Department of Epidemiology and Biostatistics, Amsterdam, 1007 MB, The Netherlands
Jean-Claude Tardif
9Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, HIT 1C8, Canada
85Department of Medicine, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada
Kent D Taylor
14Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA
Alexander Teumer
193Institute for Community Medicine, University Medicine Greifswald, Greifswald, 17475, Germany
Deborah J Thompson
80Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
Gudmar Thorleifsson
187deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland
Unnur Thorsteinsdottir
187deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland
188Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland
Betina H Thuesen
121Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, Denmark
Anke Tönjes
194Center for Pediatric Research, Department for Women’s and Child Health, University of Leipzig, Leipzig, 04103, Germany
Mina Torres
195USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA
Emmanouil Tsafantakis
196Anogia Medical Centre, Anogia, Greece
Jaakko Tuomilehto
122National Institute for Health and Welfare, Helsinki, FI-00271, Finland
197Centre for Vascular Prevention, Danube-University Krems, Krems, 3500, Austria
198Dasman Diabetes Institute, Dasman, 15462, Kuwait
199Diabetes Research Group, King Abdulaziz University, Jeddah, 21589, Saudi Arabia
André G Uitterlinden
20Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
21Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Matti Uusitupa
200Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, 70210, Finland
Cornelia M van Duijn
20Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Mauno Vanhala
201Central Finland Central Hospital, Jyvaskyla, 40620, Finland
202University of Eastern Finland, Kuopio, 70210, Finland
Rohit Varma
195USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA
Sita H Vermeulen
203Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands
Henrik Vestergaard
50The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark
204Steno Diabetes Center Copenhagen, Gentofte, 2800, Denmark
Veronique Vitart
107MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
Thomas F Vogt
205Merck, Sharp & Dohme, Cardiometabolic Disease, Kenilworth, NJ, 07033, USA
Dragana Ntalla
99Institute for Maternal and Child Health - IRCCS ״Burlo Garofolo”, Trieste, Italy
Lynne E Wagenknecht
206Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA
Mark Walker
207Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle, NE2 4HH, UK
Lars Wallentin
208Department of Medical Sciences, Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, 752 37, Sweden
Feijie Wang
111Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People’s Republic of China, Shanghai, 200031, China
Carol A Wang
164School of Women’s and Infants’ Health, The University of Western Australia, Perth, Western Australia, 6009, Australia
Shuai Wang
151Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA
Nicholas J Wareham
31MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK
Helen R Warren
16William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
57NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
Dawn M Waterworth
209Genetics, Target Sciences, GlaxoSmithKline, King of Prussia, PA, US
Jennifer Wessel
210Departments of Epidemiology & Medicine, Diabetes Translational Research Center, Fairbanks School of Public Health & School of Medicine, Indiana University, Indiana, IN, 46202, USA
Harvey D White
211Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand
Cristen J Willer
123Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Ml, 48109, USA
124Department of Internal Medicine, University of Michigan, Ann Arbor, Ml, 48109, USA
212Department of Human Genetics, University of Michigan, Ann Arbor, Ml, 48109, USA
James G Wilson
213Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA
Andrew R Wood
178Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK
Ying Wu
137Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA
Hanieh Yaghootkar
178Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK
Jie Yao
14Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA
Laura M Yerges-Armstrong
163Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, US
214GlaxoSmithKline, King of Prussia, PA, 19406, USA
Robin Young
55MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
215University of Glasgow, Glasgow, G12 8QQ, UK
Eleftheria Zeggini
72Wellcome Trust Sanger Institute, Hinxton, CB10 ISA, UK
Xiaowei Zhan
216Department of Clinical Sciences, Quantitative Biomedical Research Center, Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA
Weihua Zhang
60Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex, UB1 3HW, UK
61Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 IPG, UK
Jing Hua Zhao
31MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, CB2 0QQ, UK
Wei Zhao
179Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA
He Zheng
111Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People’s Republic of China, Shanghai, 200031, China
Wei Zhou
123Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Ml, 48109, USA
124Department of Internal Medicine, University of Michigan, Ann Arbor, Ml, 48109, USA
M Carola Zillikens
20Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
21Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Fernando Rivadeneira
20Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
21Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands
Ingrid B Borecki
28Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St.Louis, MO, 63108, USA
John A Pospisilik
15Max Planck Institute of Immunobiology and Epigenetics, Freiburg, 79108, Germany
Panos Deloukas
16William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK
217Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER- HD), King Abdulaziz University, Jeddah, 21589, Saudi Arabia
Timothy M Frayling
178Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK
Guillaume Lettre
9Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, HIT 1C8, Canada
85Department of Medicine, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, H3T 1J4, Canada
Karen L Mohlke
137Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA
Jerome I Rotter
14Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA
Zoltan Kutalik
42Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland
218Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, Switzerland
Joel N Hirschhorn
11Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
13Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA, 02115, USA
219Departments of Pediatrics and Genetics, Harvard Medical School, Boston, MA, 02115, USA
L Adrienne Cupples
27NHLBI Framingham Heart Study, Framingham, MA, 01702, USA
151Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA
Ruth JF Loos
7The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA
8The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA
220The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10069, USA
Kari E North
221Department of Epidemiology and Carolina Center of Genome Sciences, Chapel Hill, NC, 27514, USA
Cecilia M Lindgren
3Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, 0X3 7BN, UK
11Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
222Li Ka Shing Centre for Health Information and Discovery, The Big Data Institute, University of Oxford, Oxford, OX3 7BN, UK
ABSTRACT
Body fat distribution is a heritable risk factor for a range of adverse health consequences, including hyperlipidemia and type 2 diabetes. To identify protein-coding variants associated with body fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, we analyzed 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries for discovery and 132,177 independent European-ancestry individuals for validation. We identified 15 common (minor allele frequency, MAF≥5%) and 9 low frequency or rare (MAF<5%) coding variants that have not been reported previously. Pathway/gene set enrichment analyses of all associated variants highlight lipid particle, adiponectin level, abnormal white adipose tissue physiology, and bone development and morphology as processes affecting fat distribution and body shape. Furthermore, the cross-trait associations and the analyses of variant and gene function highlight a strong connection to lipids, cardiovascular traits, and type 2 diabetes. In functional follow-up analyses, specifically in Drosophila RNAi-knockdown crosses, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). By examining variants often poorly tagged or entirely missed by genome-wide association studies, we implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants.
Copyright
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Posted June 30, 2018.
Protein-Coding Variants Implicate Novel Genes Related to Lipid Homeostasis Contributing to Body Fat Distribution
Anne E Justice, Tugce Karaderi, Heather M Highland, Kristin L Young, Mariaelisa Graff, Yingchang Lu, Valérie Turcot, Paul L Auer, Rebecca S Fine, Xiuqing Guo, Claudia Schurmann, Adelheid Lempradl, Eirini Marouli, Anubha Mahajan, Thomas W Winkler, Adam E Locke, Carolina Medina-Gomez, Tõnu Esko, Sailaja Vedantam, Ayush Giri, Ken Sin Lo, Tamuno Alfred, Poorva Mudgal, Maggie CY Ng, Nancy L Heard-Costa, Mary F Feitosa, Alisa K Manning, Sara M Willems, Suthesh Sivapalaratnam, Goncalo Abecasis, Dewan S Alam, Matthew Allison, Philippe Amouyel, Zorayr Arzumanyan, Beverley Balkau, Lisa Bastarache, Sven Bergmann, Lawrence F Bielak, Matthias Blüher, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Carsten A Boger, Jette Bork-Jensen, Erwin P Bottinger, Donald W Bowden, Ivan Brandslund, Linda Broer, Amber A Burt, Adam S Butterworth, Mark J Caulfield, Giancarlo Cesana, John C Chambers, Daniel I Chasman, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, Francis S Collins, James P Cook, Amanda J Cox, David S Crosslin, John Danesh, Paul IW de Bakker, Simon de Denus, Renee de Mutsert, George Dedoussis, Ellen W Demerath, Joe G Dennis, Josh C Denny, Emanuele Di Angelantonio, Marcus Dorr, Fotios Drenos, Marie-Pierre Dube, Alison M Dunning, Douglas F Easton, Paul Elliott, Evangelos Evangelou, Aliki-Eleni Farmaki, Shuang Feng, Ele Ferrannini, Jean Ferrieres, Jose C Florez, Myriam Fornage, Caroline S Fox, Paul W Franks, Nele Friedrich, Wei Gan, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Giorgia Girotto, Mathias Gorski, Harald Grallert, Niels Grarup, Megan L Grove, Stefan Gustafsson, Jeff Haessler, Torben Hansen, Andrew T Hattersley, Caroline Hayward, Iris M Heid, Oddgeir L Holmen, G Kees Hovingh, Joanna MM Howson, Yao Hu, Yi-Jen Hung, Kristian Hveem, M Arfan Ikram, Erik Ingelsson, Anne U Jackson, Gail P Jarvik, Yucheng Jia, Torben Jørgensen, Pekka Jousilahti, Johanne M Justesen, Bratati Kahali, Maria Karaleftheri, Sharon LR Kardia, Fredrik Karpe, Frank Kee, Hidetoshi Kitajima, Pirjo Komulainen, Jaspal S Kooner, Peter Kovacs, Bernhard K Kramer, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo A Lakka, David Lamparter, Leslie A Lange, Claudia Langenberg, Eric B Larson, Nanette R Lee, Wen-Jane Lee, Terho Lehtimäki, Cora E Lewis, Huaixing Li, Jin Li, Ruifang Li-Gao, Li-An Lin, Xu Lin, Lars Lind, Jaana Lindström, Allan Linneberg, Ching-Ti Liu, Dajiang J Liu, Jian’an Luan, Leo-Pekka Lyytikäinen, Stuart MacGregor, Reedik Mägi, Satu Männistö, Gaëlle Marenne, Jonathan Marten, Nicholas GD Masca, Mark I McCarthy, Karina Meidtner, Evelin Mihailov, Leena Moilanen, Marie Moitry, Dennis O Mook-Kanamori, Anna Morgan, Andrew P Morris, Martina Muller-Nurasyid, Patricia B Munroe, Narisu Narisu, Christopher P Nelson, Matt Neville, Ioanna Ntalla, Jeffrey R O’Connel, Katharine R Owen, Oluf Pedersen, Gina M Peloso, Craig E Pennell, Markus Perola, James A Perry, John RB Perry, Tune H Pers, Ailith Pirie, Ozren Polasek, Olli T Raitakari, Asif Rasheed, Chelsea K Raulerson, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Paul M Ridker, Manuel A Rivas, Neil R Robertson, Antonietta Robino, Igor Rudan, Katherine S Ruth, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Pamela J Schreiner, Matthias B Schulze, Robert A Scott, Marcelo P Segura-Lepe, Xueling Sim, Andrew J Slater, Kerrin S Small, Blair H Smith, Jennifer A Smith, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, Kari Stefansson, Valgerdur Steinthorsdottir, Kathleen E Stirrups, Konstantin Strauch, Heather M Stringham, Michael Stumvoll, Liang Sun, Praveen Surendran, Karin MA Swart, Jean-Claude Tardif, Kent D Taylor, Alexander Teumer, Deborah J Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Betina H Thuesen, Anke Tönjes, Mina Torres, Emmanouil Tsafantakis, Jaakko Tuomilehto, André G Uitterlinden, Matti Uusitupa, Cornelia M van Duijn, Mauno Vanhala, Rohit Varma, Sita H Vermeulen, Henrik Vestergaard, Veronique Vitart, Thomas F Vogt, Dragana Ntalla, Lynne E Wagenknecht, Mark Walker, Lars Wallentin, Feijie Wang, Carol A Wang, Shuai Wang, Nicholas J Wareham, Helen R Warren, Dawn M Waterworth, Jennifer Wessel, Harvey D White, Cristen J Willer, James G Wilson, Andrew R Wood, Ying Wu, Hanieh Yaghootkar, Jie Yao, Laura M Yerges-Armstrong, Robin Young, Eleftheria Zeggini, Xiaowei Zhan, Weihua Zhang, Jing Hua Zhao, Wei Zhao, He Zheng, Wei Zhou, M Carola Zillikens, GoT2D Genes Consortium CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Fernando Rivadeneira, Ingrid B Borecki, John A Pospisilik, Panos Deloukas, Timothy M Frayling, Guillaume Lettre, Karen L Mohlke, Jerome I Rotter, Zoltan Kutalik, Joel N Hirschhorn, L Adrienne Cupples, Ruth JF Loos, Kari E North, Cecilia M Lindgren
bioRxiv 352674; doi: https://doi.org/10.1101/352674
Protein-Coding Variants Implicate Novel Genes Related to Lipid Homeostasis Contributing to Body Fat Distribution
Anne E Justice, Tugce Karaderi, Heather M Highland, Kristin L Young, Mariaelisa Graff, Yingchang Lu, Valérie Turcot, Paul L Auer, Rebecca S Fine, Xiuqing Guo, Claudia Schurmann, Adelheid Lempradl, Eirini Marouli, Anubha Mahajan, Thomas W Winkler, Adam E Locke, Carolina Medina-Gomez, Tõnu Esko, Sailaja Vedantam, Ayush Giri, Ken Sin Lo, Tamuno Alfred, Poorva Mudgal, Maggie CY Ng, Nancy L Heard-Costa, Mary F Feitosa, Alisa K Manning, Sara M Willems, Suthesh Sivapalaratnam, Goncalo Abecasis, Dewan S Alam, Matthew Allison, Philippe Amouyel, Zorayr Arzumanyan, Beverley Balkau, Lisa Bastarache, Sven Bergmann, Lawrence F Bielak, Matthias Blüher, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Carsten A Boger, Jette Bork-Jensen, Erwin P Bottinger, Donald W Bowden, Ivan Brandslund, Linda Broer, Amber A Burt, Adam S Butterworth, Mark J Caulfield, Giancarlo Cesana, John C Chambers, Daniel I Chasman, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, Francis S Collins, James P Cook, Amanda J Cox, David S Crosslin, John Danesh, Paul IW de Bakker, Simon de Denus, Renee de Mutsert, George Dedoussis, Ellen W Demerath, Joe G Dennis, Josh C Denny, Emanuele Di Angelantonio, Marcus Dorr, Fotios Drenos, Marie-Pierre Dube, Alison M Dunning, Douglas F Easton, Paul Elliott, Evangelos Evangelou, Aliki-Eleni Farmaki, Shuang Feng, Ele Ferrannini, Jean Ferrieres, Jose C Florez, Myriam Fornage, Caroline S Fox, Paul W Franks, Nele Friedrich, Wei Gan, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Giorgia Girotto, Mathias Gorski, Harald Grallert, Niels Grarup, Megan L Grove, Stefan Gustafsson, Jeff Haessler, Torben Hansen, Andrew T Hattersley, Caroline Hayward, Iris M Heid, Oddgeir L Holmen, G Kees Hovingh, Joanna MM Howson, Yao Hu, Yi-Jen Hung, Kristian Hveem, M Arfan Ikram, Erik Ingelsson, Anne U Jackson, Gail P Jarvik, Yucheng Jia, Torben Jørgensen, Pekka Jousilahti, Johanne M Justesen, Bratati Kahali, Maria Karaleftheri, Sharon LR Kardia, Fredrik Karpe, Frank Kee, Hidetoshi Kitajima, Pirjo Komulainen, Jaspal S Kooner, Peter Kovacs, Bernhard K Kramer, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo A Lakka, David Lamparter, Leslie A Lange, Claudia Langenberg, Eric B Larson, Nanette R Lee, Wen-Jane Lee, Terho Lehtimäki, Cora E Lewis, Huaixing Li, Jin Li, Ruifang Li-Gao, Li-An Lin, Xu Lin, Lars Lind, Jaana Lindström, Allan Linneberg, Ching-Ti Liu, Dajiang J Liu, Jian’an Luan, Leo-Pekka Lyytikäinen, Stuart MacGregor, Reedik Mägi, Satu Männistö, Gaëlle Marenne, Jonathan Marten, Nicholas GD Masca, Mark I McCarthy, Karina Meidtner, Evelin Mihailov, Leena Moilanen, Marie Moitry, Dennis O Mook-Kanamori, Anna Morgan, Andrew P Morris, Martina Muller-Nurasyid, Patricia B Munroe, Narisu Narisu, Christopher P Nelson, Matt Neville, Ioanna Ntalla, Jeffrey R O’Connel, Katharine R Owen, Oluf Pedersen, Gina M Peloso, Craig E Pennell, Markus Perola, James A Perry, John RB Perry, Tune H Pers, Ailith Pirie, Ozren Polasek, Olli T Raitakari, Asif Rasheed, Chelsea K Raulerson, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Paul M Ridker, Manuel A Rivas, Neil R Robertson, Antonietta Robino, Igor Rudan, Katherine S Ruth, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Pamela J Schreiner, Matthias B Schulze, Robert A Scott, Marcelo P Segura-Lepe, Xueling Sim, Andrew J Slater, Kerrin S Small, Blair H Smith, Jennifer A Smith, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, Kari Stefansson, Valgerdur Steinthorsdottir, Kathleen E Stirrups, Konstantin Strauch, Heather M Stringham, Michael Stumvoll, Liang Sun, Praveen Surendran, Karin MA Swart, Jean-Claude Tardif, Kent D Taylor, Alexander Teumer, Deborah J Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Betina H Thuesen, Anke Tönjes, Mina Torres, Emmanouil Tsafantakis, Jaakko Tuomilehto, André G Uitterlinden, Matti Uusitupa, Cornelia M van Duijn, Mauno Vanhala, Rohit Varma, Sita H Vermeulen, Henrik Vestergaard, Veronique Vitart, Thomas F Vogt, Dragana Ntalla, Lynne E Wagenknecht, Mark Walker, Lars Wallentin, Feijie Wang, Carol A Wang, Shuai Wang, Nicholas J Wareham, Helen R Warren, Dawn M Waterworth, Jennifer Wessel, Harvey D White, Cristen J Willer, James G Wilson, Andrew R Wood, Ying Wu, Hanieh Yaghootkar, Jie Yao, Laura M Yerges-Armstrong, Robin Young, Eleftheria Zeggini, Xiaowei Zhan, Weihua Zhang, Jing Hua Zhao, Wei Zhao, He Zheng, Wei Zhou, M Carola Zillikens, GoT2D Genes Consortium CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Fernando Rivadeneira, Ingrid B Borecki, John A Pospisilik, Panos Deloukas, Timothy M Frayling, Guillaume Lettre, Karen L Mohlke, Jerome I Rotter, Zoltan Kutalik, Joel N Hirschhorn, L Adrienne Cupples, Ruth JF Loos, Kari E North, Cecilia M Lindgren
bioRxiv 352674; doi: https://doi.org/10.1101/352674
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