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Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids

Steffen Möller, Nadine Saul, Alan A. Cohen, Rüdiger Köhling, Sina Sender, Hugo Murua Escobar, Christian Junghanss, Francesca Cirulli, Alessandra Berry, Peter Antal, Priit Adler, Jaak Vilo, Michele Boiani, Ludger Jansen, Stephan Struckmann, Israel Barrantes, Mohamed Hamed, Walter Luyten, Georg Fuellen
doi: https://doi.org/10.1101/355131
Steffen Möller
1Rostock University Medical Center, Institute for Biostatistics and Informatics in Medicine and Aging Research (IBIMA), Rostock, Germany
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Nadine Saul
2Humboldt-University of Berlin, Institute of Biology, Berlin, Germany
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Alan A. Cohen
3Department of Family Medicine, University of Sherbrooke, Sherbrooke, Canada
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Rüdiger Köhling
4Rostock University Medical Center, Institute for Physiology, Rostock, Germany
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Sina Sender
5Rostock University Medical Center, Klinik für Hämatologie, Onkologie und Palliativmedizin, Rostock, Germany
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Hugo Murua Escobar
5Rostock University Medical Center, Klinik für Hämatologie, Onkologie und Palliativmedizin, Rostock, Germany
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Christian Junghanss
5Rostock University Medical Center, Klinik für Hämatologie, Onkologie und Palliativmedizin, Rostock, Germany
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Francesca Cirulli
6Center for Behavioral Sciences and mental Health, Istituto Superiore di Sanità, Italy
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Alessandra Berry
6Center for Behavioral Sciences and mental Health, Istituto Superiore di Sanità, Italy
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Peter Antal
7Budapest University of Technology and Economics, Budapest, Hungary
8Abiomics Europe Ltd., Hungary
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Priit Adler
9Institute of Computer Science, BIIT research group, University of Tartu, Tartu, Estonia
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Jaak Vilo
9Institute of Computer Science, BIIT research group, University of Tartu, Tartu, Estonia
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Michele Boiani
10Max-Planck Institute for Molecular Biomedicine, Münster, Germany
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Ludger Jansen
11Ruhr-Universität Bochum, Philosophisch-Theologische Grenzfragen, Bochum, Germany
12Universität Rostock, Institut für Philosophie, Rostock, Germany
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Stephan Struckmann
1Rostock University Medical Center, Institute for Biostatistics and Informatics in Medicine and Aging Research (IBIMA), Rostock, Germany
13University Medicine Greifswald, Institute for Community Medicine, Greifswald, Germany
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Israel Barrantes
1Rostock University Medical Center, Institute for Biostatistics and Informatics in Medicine and Aging Research (IBIMA), Rostock, Germany
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Mohamed Hamed
1Rostock University Medical Center, Institute for Biostatistics and Informatics in Medicine and Aging Research (IBIMA), Rostock, Germany
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Walter Luyten
14KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium
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Georg Fuellen
1Rostock University Medical Center, Institute for Biostatistics and Informatics in Medicine and Aging Research (IBIMA), Rostock, Germany
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  • For correspondence: fuellen@uni-rostock.de
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Abstract

The molecular basis of aging and of aging-related diseases is being unraveled at an increasing pace. More recently, a long healthspan is seen as an important goal. However, a precise definition of health and healthspan is not straightforward, and the causal molecular basis of health “per se” is largely unknown. Here, we define health based on diseases and dysfunctions. Based on an extensive review of the literature, in particular for humans and C. elegans, we compile a list of features of health and of the genes associated with them. Clusters of these genes based on molecular interaction and annotation data give rise to maps of healthspan pathways for humans, featuring the themes transcription initiation, proliferation and cholesterol/lipid processing, and for C. elegans, featuring the themes immune response and the mitochondrion. Overlaying healthspan-related gene expression data (describing effects of metabolic intervention associated with improvements in health) onto the aforementioned healthspan pathway maps, we observe the downregulation of Notch signalling in humans and of proliferation/cell-cycle in C. elegans; the former reflects the proinflammatory role of the Notch pathway. Investigating the overlap of healthspan pathways of humans and C. elegans, we identify transcription, proliferation/biosynthesis and lipids as a common theme on the annotation level, and proliferation-related kinases on the gene/protein level. Our literature-based data corpus, including visualization, is available as a reference for future investigations, at http://www.h2020awe.eu/index.php/pathways/.

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  • ↵* co-first authors.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted June 25, 2018.
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Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids
Steffen Möller, Nadine Saul, Alan A. Cohen, Rüdiger Köhling, Sina Sender, Hugo Murua Escobar, Christian Junghanss, Francesca Cirulli, Alessandra Berry, Peter Antal, Priit Adler, Jaak Vilo, Michele Boiani, Ludger Jansen, Stephan Struckmann, Israel Barrantes, Mohamed Hamed, Walter Luyten, Georg Fuellen
bioRxiv 355131; doi: https://doi.org/10.1101/355131
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Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids
Steffen Möller, Nadine Saul, Alan A. Cohen, Rüdiger Köhling, Sina Sender, Hugo Murua Escobar, Christian Junghanss, Francesca Cirulli, Alessandra Berry, Peter Antal, Priit Adler, Jaak Vilo, Michele Boiani, Ludger Jansen, Stephan Struckmann, Israel Barrantes, Mohamed Hamed, Walter Luyten, Georg Fuellen
bioRxiv 355131; doi: https://doi.org/10.1101/355131

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