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An analog to digital converter creates nuclear localization pulses in yeast calcium signaling

Ian Shenyen Hsu, Bob Strome, Sergey Plotnikov, Alan M Moses
doi: https://doi.org/10.1101/357939
Ian Shenyen Hsu
University of Toronto
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Bob Strome
University of Toronto
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Sergey Plotnikov
University of Toronto
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Alan M Moses
University of Toronto
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  • For correspondence: alan.moses@utoronto.ca
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Abstract

Several examples of transcription factors that show stochastic, unsynchronized pulses of nuclear localization have been described. Here we show that under constant calcium stress, nuclear localization pulses of the transcription factor Crz1 follow stochastic variations in cytoplasmic calcium concentration. We find that the size of the stochastic calcium pulses is positively correlated with the number of subsequent Crz1 pulses. Based on our observations, we propose a simple stochastic model of how the signaling pathway converts a constant external calcium concentration into a digital number of Crz1 pulses in the nucleus, due to the time delay from nuclear transport and the stochastic decoherence of individual Crz1 molecule dynamics. We find support for several additional predictions of the model and conclude that stochastic input to nuclear transport may produce digital responses to analog signals in other signaling systems.

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Posted June 28, 2018.
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An analog to digital converter creates nuclear localization pulses in yeast calcium signaling
Ian Shenyen Hsu, Bob Strome, Sergey Plotnikov, Alan M Moses
bioRxiv 357939; doi: https://doi.org/10.1101/357939
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An analog to digital converter creates nuclear localization pulses in yeast calcium signaling
Ian Shenyen Hsu, Bob Strome, Sergey Plotnikov, Alan M Moses
bioRxiv 357939; doi: https://doi.org/10.1101/357939

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