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A Scalable, Multiplexed Assay for Decoding Receptor-Ligand Interactions

Eric M. Jones, Rishi Jajoo, Daniel Cancilla, Nathan B. Lubock, Jeff Wang, Megan Satyadi, Rocky Cheung, Claire de March, Hiroaki Matsunami, Sriram Kosuri
doi: https://doi.org/10.1101/358739
Eric M. Jones
1Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA
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Rishi Jajoo
1Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA
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Daniel Cancilla
1Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA
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Nathan B. Lubock
1Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA
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Jeff Wang
1Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA
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Megan Satyadi
1Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA
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Rocky Cheung
1Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA
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Claire de March
2Department of Molecular Genetics and Microbiology, and Department of Neurobiology and Duke Institute for Brain Sciences, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
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Hiroaki Matsunami
2Department of Molecular Genetics and Microbiology, and Department of Neurobiology and Duke Institute for Brain Sciences, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
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Sriram Kosuri
1Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA
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Article Information

doi 
https://doi.org/10.1101/358739
History 
  • June 28, 2018.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Eric M. Jones1,*,
  2. Rishi Jajoo1,*,
  3. Daniel Cancilla1,
  4. Nathan B. Lubock1,
  5. Jeff Wang1,
  6. Megan Satyadi1,
  7. Rocky Cheung1,
  8. Claire de March2,
  9. Hiroaki Matsunami2 and
  10. Sriram Kosuri1
  1. 1Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA
  2. 2Department of Molecular Genetics and Microbiology, and Department of Neurobiology and Duke Institute for Brain Sciences, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
  1. Correspondence should be addressed to S.K. (sri{at}ucla.edu)
  1. ↵* Equal Contribution

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A Scalable, Multiplexed Assay for Decoding Receptor-Ligand Interactions
Eric M. Jones, Rishi Jajoo, Daniel Cancilla, Nathan B. Lubock, Jeff Wang, Megan Satyadi, Rocky Cheung, Claire de March, Hiroaki Matsunami, Sriram Kosuri
bioRxiv 358739; doi: https://doi.org/10.1101/358739
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A Scalable, Multiplexed Assay for Decoding Receptor-Ligand Interactions
Eric M. Jones, Rishi Jajoo, Daniel Cancilla, Nathan B. Lubock, Jeff Wang, Megan Satyadi, Rocky Cheung, Claire de March, Hiroaki Matsunami, Sriram Kosuri
bioRxiv 358739; doi: https://doi.org/10.1101/358739

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