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Chicken uric acid elimination via the uric acid transporters BCRP and MRP4 in the liver, kidneys, and intestines

Xuedong Ding, Manman Li, Shoufa Qian, Yuying Ma, Tianyi Fang, Xinlu Li, Huan Liu, Shibin Feng, Yu Li, Xichun Wang, Jinchun Li, View ORCID ProfileJinjie Wu
doi: https://doi.org/10.1101/358994
Xuedong Ding
College of Animal Science and Technology, Clinical Veterinary Medicine, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China
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Manman Li
College of Animal Science and Technology, Clinical Veterinary Medicine, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China
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Shoufa Qian
College of Animal Science and Technology, Clinical Veterinary Medicine, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China
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Yuying Ma
College of Animal Science and Technology, Clinical Veterinary Medicine, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China
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Tianyi Fang
College of Animal Science and Technology, Clinical Veterinary Medicine, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China
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Xinlu Li
College of Animal Science and Technology, Clinical Veterinary Medicine, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China
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Huan Liu
College of Animal Science and Technology, Clinical Veterinary Medicine, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China
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Shibin Feng
College of Animal Science and Technology, Clinical Veterinary Medicine, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China
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Yu Li
College of Animal Science and Technology, Clinical Veterinary Medicine, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China
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Xichun Wang
College of Animal Science and Technology, Clinical Veterinary Medicine, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China
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Jinchun Li
College of Animal Science and Technology, Clinical Veterinary Medicine, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China
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Jinjie Wu
College of Animal Science and Technology, Clinical Veterinary Medicine, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China
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  • ORCID record for Jinjie Wu
  • For correspondence: wjj@ahau.edu.cn
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Abstract

Breast cancer resistance protein (BCRP) and multidrug resistance protein 4 (MRP4) are involved in uric acid excretion in humans and mice. Despite evidence suggesting that chicken renal proximal tubular epithelial cells participate in uric acid secretion, the roles of BCRP and MRP4 in chickens remain unclear. This study evaluated the relationship between chicken BCRP and MRP4 expression and renal function in the liver, kidneys, and intestines. Sixty 20-day-old Isa brown laying hens were randomly divided into four groups: a control group (NC) and groups provided with sulfonamide-treated drinking water (SD), a diet supplemented with fishmeal (FM), and an intraperitoneal injection of uric acid (IU). Serum uric acid, creatinine, and blood urea nitrogen (BUN) levels were significantly higher in the SD and IU groups than in the NC group. BCRP and MRP4 levels in the SD and IU groups were significantly increased in the kidneys and ileum and decreased in the liver. In the FM group, BCRP and MRP4 were significantly increased in the kidneys and slightly increased in the ileum. These results demonstrate that chicken BCRP and MRP4 are involved in renal and intestinal uric acid excretion. When renal function is impaired, serum uric acid increased and BCRP and MRP4 in the liver, kidneys, and ileum exhibit compensatory increases; when renal function is normal, serum uric acid changes have no effect on ileum BCRP and MRP4 expression. Therefore, this study may provide the references to the uric acid regulation in human.

Summary statement: The uric transporters BCRP and MRP4 in different tissues may exhibit the interaction to maintain the serum uric acid levels.

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Posted June 29, 2018.
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Chicken uric acid elimination via the uric acid transporters BCRP and MRP4 in the liver, kidneys, and intestines
Xuedong Ding, Manman Li, Shoufa Qian, Yuying Ma, Tianyi Fang, Xinlu Li, Huan Liu, Shibin Feng, Yu Li, Xichun Wang, Jinchun Li, Jinjie Wu
bioRxiv 358994; doi: https://doi.org/10.1101/358994
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Chicken uric acid elimination via the uric acid transporters BCRP and MRP4 in the liver, kidneys, and intestines
Xuedong Ding, Manman Li, Shoufa Qian, Yuying Ma, Tianyi Fang, Xinlu Li, Huan Liu, Shibin Feng, Yu Li, Xichun Wang, Jinchun Li, Jinjie Wu
bioRxiv 358994; doi: https://doi.org/10.1101/358994

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