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Most sleep does not serve a vital function. Evidence from Drosophila melanogaster

View ORCID ProfileQuentin Geissmann, View ORCID ProfileEsteban J. Beckwith, View ORCID ProfileGiorgio F. Gilestro
doi: https://doi.org/10.1101/361667
Quentin Geissmann
1Department of Life Sciences, Imperial College London, London, U.K.
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Esteban J. Beckwith
1Department of Life Sciences, Imperial College London, London, U.K.
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Giorgio F. Gilestro
1Department of Life Sciences, Imperial College London, London, U.K.
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Abstract

Sleep appears to be a universally conserved phenomenon among the animal kingdom but whether this striking evolutionary conservation underlies a basic vital function is still an open question. Using novel technologies, we conducted an unprecedentedly detailed high-throughput analysis of sleep in the fruit fly Drosophila melanogaster, coupled with a life-long chronic and specific sleep restriction. Our results show that some wild-type flies are virtually sleepless in baseline conditions and that complete, forced sleep restriction is not necessarily a lethal treatment in wild-type Drosophila melanogaster. We also show that circadian drive, and not homeostatic regulation, is the main contributor to sleep pressure in flies. We propose a three-partite model framework of sleep function, according to which, total sleep accounts for three components: a vital component, a useful component, and an accessory component.

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Posted July 04, 2018.
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Most sleep does not serve a vital function. Evidence from Drosophila melanogaster
Quentin Geissmann, Esteban J. Beckwith, Giorgio F. Gilestro
bioRxiv 361667; doi: https://doi.org/10.1101/361667
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Most sleep does not serve a vital function. Evidence from Drosophila melanogaster
Quentin Geissmann, Esteban J. Beckwith, Giorgio F. Gilestro
bioRxiv 361667; doi: https://doi.org/10.1101/361667

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