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Modulatory effect of Syzygium aromaticum and Pelargonium graveolens on oxidative stress and inflammation

View ORCID ProfileIlias Marmouzi, Karym El Mostafa, Rachid Alami, Meryem El Jemli, Mourad Kharbach, Fouzia Mamouch, Bouchra Faridi, Aisha Attar, Yahia Cherrah, My El Abbes Faouzi
doi: https://doi.org/10.1101/362426
Ilias Marmouzi
University Mohammed V in Rabat;
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  • For correspondence: ilias.marmouzi@gmail.com
Karym El Mostafa
University Hassan I
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Rachid Alami
University Mohammed V in Rabat;
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Meryem El Jemli
University Mohammed V in Rabat;
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Mourad Kharbach
University Mohammed V in Rabat;
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Fouzia Mamouch
University Mohammed V in Rabat;
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Bouchra Faridi
University Mohammed V in Rabat;
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Aisha Attar
University Mohammed V in Rabat;
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Yahia Cherrah
University Mohammed V in Rabat;
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My El Abbes Faouzi
University Mohammed V in Rabat;
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Abstract

Background: Therapy combination is defined as disease treatment with two or more medication to acheive efficacy with lower doses or lower toxicity. Regarding its reported toxicities and efficacy, the Essential Oils (EOs) from Syzygium aromaticum (SA) and Pelargonium graveolens (PG) were combined for in vitro and in vivo assays and toxicities. Methods: The Essential Oils and mixture were tested for in vivo/in vitro antioxidant and anti-inflammatory activities. The assays included the animal model of acute inflammation (carrageenan model), the protective effect on H2O2/Sodium nitroprissude induced stress in Tetrahymena pyriformis, and the in vitro antioxidant assays. Results: The chemical analysis of the investigated Oils has lead to the identification of Eugenol (74.06%), Caryophyllene (11.52%) and Carvacrol acetate (7.82%) as the major element in SA; while PG was much higher in Citronellol (30.77%), 10-epi-γ-Eudesmol (22.59%), and Geraniol (13.95%). In our pharmacological screening of samples, both Oils demonstrated good antioxidant effects. In vivo investigation of the antioxidant activity in the protozoa model (T. pyriformis) demonstrated a lesser toxic effect of EOs mixture with no significant differences when oxidative stress markers and antioxidant enzymes (MDA, SOD and CAT) were evaluated. On the other hand the in vivo model of inflammatory response to carrageenan demonstrated a good inhibitory potential of both EOs. The EOs Mixture demonstrated equivalent bioactivity with lower toxic effect and minimal risk for each compound. Conclusions: The results from this study indicate that EOs mixture from SA and PG demonstrated promising modulatory antioxidant/anti-inflammatory effect, which suggest an efficient association for therapy.

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Posted July 04, 2018.
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Modulatory effect of Syzygium aromaticum and Pelargonium graveolens on oxidative stress and inflammation
Ilias Marmouzi, Karym El Mostafa, Rachid Alami, Meryem El Jemli, Mourad Kharbach, Fouzia Mamouch, Bouchra Faridi, Aisha Attar, Yahia Cherrah, My El Abbes Faouzi
bioRxiv 362426; doi: https://doi.org/10.1101/362426
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Modulatory effect of Syzygium aromaticum and Pelargonium graveolens on oxidative stress and inflammation
Ilias Marmouzi, Karym El Mostafa, Rachid Alami, Meryem El Jemli, Mourad Kharbach, Fouzia Mamouch, Bouchra Faridi, Aisha Attar, Yahia Cherrah, My El Abbes Faouzi
bioRxiv 362426; doi: https://doi.org/10.1101/362426

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