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Modulatory effect of Syzygium aromaticum and Pelargonium graveolens on oxidative stress and inflammation

View ORCID ProfileIlias Marmouzi, El Mostafa Karym, Rachid Alami, Meryem El Jemli, Mourad Kharbach, Fouzia Mamouch, Bouchra Faridi, Aisha Attar, Yahia Cherrah, My El Abbes Faouzi
doi: https://doi.org/10.1101/362426
Ilias Marmouzi
1Mohammed V University in Rabat, Faculté de Médecine et Pharmacie, Laboratoire de Pharmacologie et Toxicologie, équipe de Pharmacocinétique
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  • ORCID record for Ilias Marmouzi
  • For correspondence: ilias.marmouzi@gmail.com
El Mostafa Karym
2Laboratoire de Biochimie et Neurosciences, FST, Université Hassan I, BP 577, Settat 26 000, Morocco
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Rachid Alami
1Mohammed V University in Rabat, Faculté de Médecine et Pharmacie, Laboratoire de Pharmacologie et Toxicologie, équipe de Pharmacocinétique
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Meryem El Jemli
1Mohammed V University in Rabat, Faculté de Médecine et Pharmacie, Laboratoire de Pharmacologie et Toxicologie, équipe de Pharmacocinétique
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Mourad Kharbach
3Pharmaceutical and Toxicological Analysis Research Team, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat 10100, Morocco
4Department of Analytical Chemistry, Applied Chemometrics and Molecular Modelling, CePhaR, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090 Brussels 1090, Belgium
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Fouzia Mamouch
5Medical oncology Departement, National Institute of Instruction
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Bouchra Faridi
1Mohammed V University in Rabat, Faculté de Médecine et Pharmacie, Laboratoire de Pharmacologie et Toxicologie, équipe de Pharmacocinétique
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Aisha Attar
6Faculty of Science and Techniques, Hassan II University of Casablanca, Mohammedia, Morocco
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Yahia Cherrah
1Mohammed V University in Rabat, Faculté de Médecine et Pharmacie, Laboratoire de Pharmacologie et Toxicologie, équipe de Pharmacocinétique
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My El Abbes Faouzi
1Mohammed V University in Rabat, Faculté de Médecine et Pharmacie, Laboratoire de Pharmacologie et Toxicologie, équipe de Pharmacocinétique
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Abstract

Background Therapy combination is defined as disease treatment with two or more medication to acheive efficacy with lower doses or lower toxicity. Regarding its reported toxicities and efficacy, the Essential Oils (EOs) from Syzygium aromaticum (SA) and Pelargonium graveolens (PG) were combined for in vitro and in vivo assays and toxicities.

Methods The Essential Oils and mixture were tested for in vivo/in vitro antioxidant and anti-inflammatory activities. The assays included the animal model of acute inflammation (carrageenan model), the protective effect on H2O2/Sodium nitroprissude induced stress in Tetrahymena pyriformis, and the in vitro antioxidant assays.

Results The chemical analysis of the investigated Oils has lead to the identification of Eugenol (74.06%), Caryophyllene (11.52%) and Carvacrol acetate (7.82%) as the major element in SA; while PG was much higher in Citronellol (30.77%), 10-epi-γ-Eudesmol (22.59%), and Geraniol (13.95%). In our pharmacological screening of samples, both Oils demonstrated good antioxidant effects. In vivo investigation of the antioxidant activity in the protozoa model (T. pyriformis) demonstrated a lesser toxic effect of EOs mixture with no significant differences when oxidative stress markers and antioxidant enzymes (MDA, SOD and CAT) were evaluated. On the other hand the in vivo model of inflammatory response to carrageenan demonstrated a good inhibitory potential of both EOs. The EOs Mixture demonstrated equivalent bioactivity with lower toxic effect and minimal risk for each compound.

Conclusions The results from this study indicate that EOs mixture from SA and PG demonstrated promising modulatory antioxidant/anti-inflammatory effect, which suggest an efficient association for therapy.

Copyright 
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Posted July 04, 2018.
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Modulatory effect of Syzygium aromaticum and Pelargonium graveolens on oxidative stress and inflammation
Ilias Marmouzi, El Mostafa Karym, Rachid Alami, Meryem El Jemli, Mourad Kharbach, Fouzia Mamouch, Bouchra Faridi, Aisha Attar, Yahia Cherrah, My El Abbes Faouzi
bioRxiv 362426; doi: https://doi.org/10.1101/362426
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Modulatory effect of Syzygium aromaticum and Pelargonium graveolens on oxidative stress and inflammation
Ilias Marmouzi, El Mostafa Karym, Rachid Alami, Meryem El Jemli, Mourad Kharbach, Fouzia Mamouch, Bouchra Faridi, Aisha Attar, Yahia Cherrah, My El Abbes Faouzi
bioRxiv 362426; doi: https://doi.org/10.1101/362426

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