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Connectivity and network state-dependent recruitment of long-range VIP-GABAergic neurons in the mouse hippocampus

Ruggiero Francavilla, Vincent Villette, Xiao Luo, Simon Chamberland, Einer Muñoz-Pino, Olivier Camiré, Kristina Wagner, Viktor Kis, Peter Somogyi, Lisa Topolnik
doi: https://doi.org/10.1101/364547
Ruggiero Francavilla
1Dept. Biochemistry, Microbiology and Bio-informatics; Neuroscience Axis, CHU de Québec Research Center, Université Laval, Québec, PQ, G1V 0A6, Canada
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Vincent Villette
1Dept. Biochemistry, Microbiology and Bio-informatics; Neuroscience Axis, CHU de Québec Research Center, Université Laval, Québec, PQ, G1V 0A6, Canada
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Xiao Luo
1Dept. Biochemistry, Microbiology and Bio-informatics; Neuroscience Axis, CHU de Québec Research Center, Université Laval, Québec, PQ, G1V 0A6, Canada
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Simon Chamberland
1Dept. Biochemistry, Microbiology and Bio-informatics; Neuroscience Axis, CHU de Québec Research Center, Université Laval, Québec, PQ, G1V 0A6, Canada
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Einer Muñoz-Pino
1Dept. Biochemistry, Microbiology and Bio-informatics; Neuroscience Axis, CHU de Québec Research Center, Université Laval, Québec, PQ, G1V 0A6, Canada
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Olivier Camiré
1Dept. Biochemistry, Microbiology and Bio-informatics; Neuroscience Axis, CHU de Québec Research Center, Université Laval, Québec, PQ, G1V 0A6, Canada
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Kristina Wagner
2Dept. Pharmacology, Oxford University, Oxford, OX1 3QT, UK
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Viktor Kis
2Dept. Pharmacology, Oxford University, Oxford, OX1 3QT, UK
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Peter Somogyi
2Dept. Pharmacology, Oxford University, Oxford, OX1 3QT, UK
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Lisa Topolnik
1Dept. Biochemistry, Microbiology and Bio-informatics; Neuroscience Axis, CHU de Québec Research Center, Université Laval, Québec, PQ, G1V 0A6, Canada
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Abstract

GABAergic interneurons in the hippocampus provide for local and long-distance coordination of neurons in functionally connected areas. Vasoactive intestinal peptide-expressing (VIP+) interneurons occupy a distinct niche in circuitry as many of them specialize in innervating GABAergic cells, thus providing network disinhibition. In the CA1 hippocampus, VIP+ interneuron-selective cells target local interneurons. Here, we discovered a novel type of VIP+ neuron whose axon innervates CA1 and also projects to the subiculum (VIP-LRPs). VIP-LRPs showed specific molecular properties and targeted interneurons within the CA1 area but both interneurons and pyramidal cells within subiculum. They were interconnected through gap junctions but demonstrated sparse spike coupling in vitro. In awake mice, VIP-LRPs decreased their activity during theta-run epochs and were more active during quiet wakefulness but not coupled to sharp-wave ripples. Together, the data provide new evidence for VIP interneuron molecular diversity and functional specialization in controlling cell ensembles along the hippocampo-subicular axis.

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Posted July 15, 2018.
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Connectivity and network state-dependent recruitment of long-range VIP-GABAergic neurons in the mouse hippocampus
Ruggiero Francavilla, Vincent Villette, Xiao Luo, Simon Chamberland, Einer Muñoz-Pino, Olivier Camiré, Kristina Wagner, Viktor Kis, Peter Somogyi, Lisa Topolnik
bioRxiv 364547; doi: https://doi.org/10.1101/364547
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Connectivity and network state-dependent recruitment of long-range VIP-GABAergic neurons in the mouse hippocampus
Ruggiero Francavilla, Vincent Villette, Xiao Luo, Simon Chamberland, Einer Muñoz-Pino, Olivier Camiré, Kristina Wagner, Viktor Kis, Peter Somogyi, Lisa Topolnik
bioRxiv 364547; doi: https://doi.org/10.1101/364547

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