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A three year follow-up study of gadolinium enhanced and non-enhanced regions in multiple sclerosis lesions using a multi-compartment T2 relaxometry model

View ORCID ProfileSudhanya Chatterjee, Olivier Commowick, Onur Afacan, Benoit Combes, Simon K. Warfield, Christian Barillot
doi: https://doi.org/10.1101/365379
Sudhanya Chatterjee
1Univ Rennes, CNRS, Inria, Inserm, IRISA UMR 6074, VISAGES (Vision, action et gestion des informations en santé - ERL U 1228, F-35000 Rennes, France
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  • ORCID record for Sudhanya Chatterjee
Olivier Commowick
1Univ Rennes, CNRS, Inria, Inserm, IRISA UMR 6074, VISAGES (Vision, action et gestion des informations en santé - ERL U 1228, F-35000 Rennes, France
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Onur Afacan
2Computational Radiology Laboratory, Boston Children’s Hospital, Department of Radiology, 300 Longwood Avenue, WB215, Boston, MA 02115, USA
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Benoit Combes
1Univ Rennes, CNRS, Inria, Inserm, IRISA UMR 6074, VISAGES (Vision, action et gestion des informations en santé - ERL U 1228, F-35000 Rennes, France
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Simon K. Warfield
2Computational Radiology Laboratory, Boston Children’s Hospital, Department of Radiology, 300 Longwood Avenue, WB215, Boston, MA 02115, USA
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Christian Barillot
1Univ Rennes, CNRS, Inria, Inserm, IRISA UMR 6074, VISAGES (Vision, action et gestion des informations en santé - ERL U 1228, F-35000 Rennes, France
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Abstract

Demyelination, axonal damage and inflammation are critical indicators of the onset and progress of neurodegenerative diseases such as multiple sclerosis (MS) in patients. Due to physical limitations of imaging such as acquisition time and imaging resolution, a voxel in a MR image is heterogeneous in terms of tissue microstructure such as myelin, axons, intra and extra cellular fluids and free water. We present a multi-compartment tissue model which estimates the water fraction (WF) of tissues with short, medium and high T2 relaxation times in a T2 relaxometry MRI voxel. The proposed method is validated on test-retest data of healthy controls. This model was then used to study longitudinal trends of the tissue microstructures for two sub-regions of the lesions: gadolinium enhanced (E+) and non-enhanced (L–) regions of MS lesions in 10 MS patients over a period of three years. The water fraction values in E+ and L– regions were found to be significantly different (p < 0.05) over the period of first three months. The results of this study also showed that the estimates of the proposed T2 relaxometry model on brain tissue microstructures have potential to distinguish between regions undergoing active blood brain barrier breakdown from the other regions of the lesion.

Footnotes

  • ↵* sudhanya.chatterjee{at}irisa.fr

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted July 09, 2018.
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A three year follow-up study of gadolinium enhanced and non-enhanced regions in multiple sclerosis lesions using a multi-compartment T2 relaxometry model
Sudhanya Chatterjee, Olivier Commowick, Onur Afacan, Benoit Combes, Simon K. Warfield, Christian Barillot
bioRxiv 365379; doi: https://doi.org/10.1101/365379
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A three year follow-up study of gadolinium enhanced and non-enhanced regions in multiple sclerosis lesions using a multi-compartment T2 relaxometry model
Sudhanya Chatterjee, Olivier Commowick, Onur Afacan, Benoit Combes, Simon K. Warfield, Christian Barillot
bioRxiv 365379; doi: https://doi.org/10.1101/365379

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