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Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D

Jun Jacob Hu, Xing Liu, Jingxia Zhao, Shiyu Xia, Jianbin Ruan, Xuemei Luo, Justin Kim, Judy Lieberman, Hao Wu
doi: https://doi.org/10.1101/365908
Jun Jacob Hu
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
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Xing Liu
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
3Department of Paediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
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Jingxia Zhao
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
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Shiyu Xia
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
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Jianbin Ruan
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
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Xuemei Luo
4Biomolecular Resource Facility, University of Texas Medical Branch, Galveston, Texas 77555, USA
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Justin Kim
2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
5Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA
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Judy Lieberman
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
3Department of Paediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
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  • For correspondence: judy.lieberman@childrens.harvard.edu wu@crystal.harvard.edu
Hao Wu
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
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  • For correspondence: judy.lieberman@childrens.harvard.edu wu@crystal.harvard.edu
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Posted July 10, 2018.
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Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D
Jun Jacob Hu, Xing Liu, Jingxia Zhao, Shiyu Xia, Jianbin Ruan, Xuemei Luo, Justin Kim, Judy Lieberman, Hao Wu
bioRxiv 365908; doi: https://doi.org/10.1101/365908
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Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D
Jun Jacob Hu, Xing Liu, Jingxia Zhao, Shiyu Xia, Jianbin Ruan, Xuemei Luo, Justin Kim, Judy Lieberman, Hao Wu
bioRxiv 365908; doi: https://doi.org/10.1101/365908

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