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Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D
Jun Jacob Hu, Xing Liu, Jingxia Zhao, Shiyu Xia, Jianbin Ruan, Xuemei Luo, Justin Kim, Judy Lieberman, Hao Wu
doi: https://doi.org/10.1101/365908
Jun Jacob Hu
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
Xing Liu
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
3Department of Paediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
Jingxia Zhao
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
Shiyu Xia
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
Jianbin Ruan
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
Xuemei Luo
4Biomolecular Resource Facility, University of Texas Medical Branch, Galveston, Texas 77555, USA
Justin Kim
2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
5Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA
Judy Lieberman
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
3Department of Paediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
Hao Wu
1Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts 02115, USA
2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA

Article usage
Posted July 10, 2018.
Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D
Jun Jacob Hu, Xing Liu, Jingxia Zhao, Shiyu Xia, Jianbin Ruan, Xuemei Luo, Justin Kim, Judy Lieberman, Hao Wu
bioRxiv 365908; doi: https://doi.org/10.1101/365908
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