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Shared Song Detector Neurons in Drosophila Male and Female Brains Drive Sex-Specific Behaviors

David Deutsch, View ORCID ProfileJan Clemens, View ORCID ProfileStephan Y. Thiberge, Georgia Guan, View ORCID ProfileMala Murthy
doi: https://doi.org/10.1101/366765
David Deutsch
1Princeton Neuroscience Institute, Princeton University, Princeton 08540, NJ, USA
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Jan Clemens
1Princeton Neuroscience Institute, Princeton University, Princeton 08540, NJ, USA
2European Neuroscience Institute, Grisebachstrasse 5, Göttingen, Germany
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Stephan Y. Thiberge
1Princeton Neuroscience Institute, Princeton University, Princeton 08540, NJ, USA
3Bezos Center for Neural Circuit Dynamics, Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
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Georgia Guan
1Princeton Neuroscience Institute, Princeton University, Princeton 08540, NJ, USA
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Mala Murthy
1Princeton Neuroscience Institute, Princeton University, Princeton 08540, NJ, USA
3Bezos Center for Neural Circuit Dynamics, Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
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  • For correspondence: mmurthy@princeton.edu
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Abstract

Males and females often produce distinct responses to the same sensory stimuli. How such differences arise – at the level of sensory processing or in the circuits that generate behavior – remains largely unresolved across sensory modalities. We address this issue in the acoustic communication system of Drosophila. During courtship, males generate time-varying songs, and each sex responds with specific behaviors. We characterize male and female behavioral tuning for all aspects of song, and show that feature tuning is similar between sexes, suggesting sex-shared song detectors drive divergent behaviors. We then identify higher-order neurons in the Drosophila brain, called pC2, that are tuned for multiple temporal aspects of one mode of the male’s song, and drive sex-specific behaviors. We thus uncover neurons that are specifically tuned to an acoustic communication signal and that reside at the sensory-motor interface, flexibly linking auditory perception with sex-specific behavioral responses.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted July 21, 2019.
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Shared Song Detector Neurons in Drosophila Male and Female Brains Drive Sex-Specific Behaviors
David Deutsch, Jan Clemens, Stephan Y. Thiberge, Georgia Guan, Mala Murthy
bioRxiv 366765; doi: https://doi.org/10.1101/366765
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Shared Song Detector Neurons in Drosophila Male and Female Brains Drive Sex-Specific Behaviors
David Deutsch, Jan Clemens, Stephan Y. Thiberge, Georgia Guan, Mala Murthy
bioRxiv 366765; doi: https://doi.org/10.1101/366765

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