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Rheumatoid arthritis heritability is concentrated in regulatory elements with CD4+ T cell-state-specific transcription factor binding profiles
Tiffany Amariuta, Yang Luo, Steven Gazal, Emma E. Davenport, Bryce van de Geijn, Harm-Jan Westra, Nikola Teslovich, Yukinori Okada, Kazuhiko Yamamoto, RACI consortium, GARNET consortium, Alkes Price, Soumya Raychaudhuri
doi: https://doi.org/10.1101/366864
Tiffany Amariuta
1Center for Data Sciences, Harvard Medical School, Boston, Massachusetts, USA
2Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
4Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA
5Graduate School of Arts and Sciences, Harvard University, Boston, Massachusetts, USA
Yang Luo
1Center for Data Sciences, Harvard Medical School, Boston, Massachusetts, USA
2Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
Steven Gazal
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
6Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
Emma E. Davenport
1Center for Data Sciences, Harvard Medical School, Boston, Massachusetts, USA
2Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
Bryce van de Geijn
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
6Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
Harm-Jan Westra
1Center for Data Sciences, Harvard Medical School, Boston, Massachusetts, USA
2Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
7Faculty of Medical Sciences, University of Groningen, Groningen, Netherlands
Nikola Teslovich
2Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Yukinori Okada
8Division of Medicine, Osaka University, Osaka, Japan
9Osaka University Graduate School of Medicine, Osaka, Japan
Kazuhiko Yamamoto
10Immunology Frontier Research Center (WPI-IFReC), Osaka University, Osaka, Japan
Alkes Price
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
6Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
11Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
Soumya Raychaudhuri
1Center for Data Sciences, Harvard Medical School, Boston, Massachusetts, USA
2Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
4Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA
5Graduate School of Arts and Sciences, Harvard University, Boston, Massachusetts, USA
12Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
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Posted July 12, 2018.
Rheumatoid arthritis heritability is concentrated in regulatory elements with CD4+ T cell-state-specific transcription factor binding profiles
Tiffany Amariuta, Yang Luo, Steven Gazal, Emma E. Davenport, Bryce van de Geijn, Harm-Jan Westra, Nikola Teslovich, Yukinori Okada, Kazuhiko Yamamoto, RACI consortium, GARNET consortium, Alkes Price, Soumya Raychaudhuri
bioRxiv 366864; doi: https://doi.org/10.1101/366864
Rheumatoid arthritis heritability is concentrated in regulatory elements with CD4+ T cell-state-specific transcription factor binding profiles
Tiffany Amariuta, Yang Luo, Steven Gazal, Emma E. Davenport, Bryce van de Geijn, Harm-Jan Westra, Nikola Teslovich, Yukinori Okada, Kazuhiko Yamamoto, RACI consortium, GARNET consortium, Alkes Price, Soumya Raychaudhuri
bioRxiv 366864; doi: https://doi.org/10.1101/366864
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