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Neurotensin and Dynorphin Bi-Directionally Modulates CeA Inhibition of oval BNST Neurons in Male Mice

CP Normandeau, ML Torruella Suárez, P Sarret, View ORCID ProfileZA McElligott, EC Dumont
doi: https://doi.org/10.1101/367649
CP Normandeau
1Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada
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ML Torruella Suárez
2Program in Neurobiology, School of Medicine, University of North Carolina at Chapel Hill
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P Sarret
3Department of Pharmacology & Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada
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ZA McElligott
4Bowles Center for Alcohol Studies and Departments of Psychiatry and Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, USA
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EC Dumont
1Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada
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Abstract

Neuropeptides are often co-expressed in neurons but their neurophysiological effects are commonly studied individually. Multiple neuropeptides may therefore be simultaneously released to coordinate proper neural circuit function. Here, we triggered the release of endogenous neuropeptides in brain slices from male mice to better understand the modulation of central amygdala (CeA) inhibitory inputs onto oval (ov) BNST neurons. We found that locally-released neurotensin (NT) and dynorphin (Dyn) antagonistically regulated CeA inhibitory inputs onto ovBNST neurons. NT and Dyn respectively increased and decreased CeA-to-ovBNST inhibitory inputs through NT receptor 1 (NTR1) and kappa opioid receptor (KOR). Additionally, NT and Dyn mRNAs were highly co-localized in ovBNST neurons suggesting that they may be released from the same cells. Together, we showed that NT and Dyn are key modulators of CeA inputs to ovBNST, paving the way to determine whether different conditions or states can alter the neuropeptidergic regulation of this particular brain circuit.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted July 11, 2018.
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Neurotensin and Dynorphin Bi-Directionally Modulates CeA Inhibition of oval BNST Neurons in Male Mice
CP Normandeau, ML Torruella Suárez, P Sarret, ZA McElligott, EC Dumont
bioRxiv 367649; doi: https://doi.org/10.1101/367649
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Neurotensin and Dynorphin Bi-Directionally Modulates CeA Inhibition of oval BNST Neurons in Male Mice
CP Normandeau, ML Torruella Suárez, P Sarret, ZA McElligott, EC Dumont
bioRxiv 367649; doi: https://doi.org/10.1101/367649

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