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The genome of the jellyfish Clytia hemisphaerica and the evolution of the cnidarian life-cycle

Lucas Leclère, Coralie Horin, Sandra Chevalier, Pascal Lapébie, Philippe Dru, Sophie Peron, Muriel Jager, Thomas Condamine, Karen Pottin, Séverine Romano, Julia Steger, Chiara Sinigaglia, Carine Barreau, Gonzalo Quiroga Artigas, Antonella Ruggiero, Cécile Fourrage, Johanna E. M. Kraus, Julie Poulain, Jean-Marc Aury, Patrick Wincker, Eric Quéinnec, Ulrich Technau, Michaël Manuel, Tsuyoshi Momose, Evelyn Houliston, Richard R. Copley
doi: https://doi.org/10.1101/369959
Lucas Leclère
1Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), 06230 Villefranche-sur-mer, France
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Coralie Horin
1Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), 06230 Villefranche-sur-mer, France
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Sandra Chevalier
1Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), 06230 Villefranche-sur-mer, France
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Pascal Lapébie
1Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), 06230 Villefranche-sur-mer, France
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Philippe Dru
1Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), 06230 Villefranche-sur-mer, France
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Sophie Peron
1Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), 06230 Villefranche-sur-mer, France
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Muriel Jager
2Sorbonne Université, CNRS, Institut de Biologie Paris-Seine (IBPS), Evolution Paris-Seine (UMR7138), Case 05, 7 Quai St Bernard, 75005, Paris, France
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Thomas Condamine
2Sorbonne Université, CNRS, Institut de Biologie Paris-Seine (IBPS), Evolution Paris-Seine (UMR7138), Case 05, 7 Quai St Bernard, 75005, Paris, France
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Karen Pottin
2Sorbonne Université, CNRS, Institut de Biologie Paris-Seine (IBPS), Evolution Paris-Seine (UMR7138), Case 05, 7 Quai St Bernard, 75005, Paris, France
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Séverine Romano
1Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), 06230 Villefranche-sur-mer, France
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Julia Steger
1Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), 06230 Villefranche-sur-mer, France
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Chiara Sinigaglia
1Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), 06230 Villefranche-sur-mer, France
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Carine Barreau
1Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), 06230 Villefranche-sur-mer, France
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Gonzalo Quiroga Artigas
1Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), 06230 Villefranche-sur-mer, France
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Antonella Ruggiero
1Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), 06230 Villefranche-sur-mer, France
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Cécile Fourrage
1Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), 06230 Villefranche-sur-mer, France
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Johanna E. M. Kraus
5Department for Molecular Evolution and Development, Centre of Organismal Systems Biology, University of Vienna, Vienna A-1090, Austria
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Julie Poulain
3Commissariat à l’Energie Atomique (CEA), Institut de Biologie François-Jacob, Genoscope, 19 CNRS UMR 8030, Université d’Evry, France
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Jean-Marc Aury
4Commissariat à l’Energie Atomique (CEA), Institut de Biologie François-Jacob, Genoscope, 13 F-91057 Evry, France
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Patrick Wincker
3Commissariat à l’Energie Atomique (CEA), Institut de Biologie François-Jacob, Genoscope, 19 CNRS UMR 8030, Université d’Evry, France
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Eric Quéinnec
2Sorbonne Université, CNRS, Institut de Biologie Paris-Seine (IBPS), Evolution Paris-Seine (UMR7138), Case 05, 7 Quai St Bernard, 75005, Paris, France
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Ulrich Technau
5Department for Molecular Evolution and Development, Centre of Organismal Systems Biology, University of Vienna, Vienna A-1090, Austria
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Michaël Manuel
2Sorbonne Université, CNRS, Institut de Biologie Paris-Seine (IBPS), Evolution Paris-Seine (UMR7138), Case 05, 7 Quai St Bernard, 75005, Paris, France
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Tsuyoshi Momose
1Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), 06230 Villefranche-sur-mer, France
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Evelyn Houliston
1Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), 06230 Villefranche-sur-mer, France
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Richard R. Copley
1Sorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), 06230 Villefranche-sur-mer, France
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Abstract

Jellyfish (medusae) are a distinctive life-cycle stage of medusozoan cnidarians. They are major marine predators, with integrated neurosensory, muscular and organ systems. The genetic foundations of this complex form are largely unknown. We report the draft genome of the hydrozoan jellyfish Clytia hemisphaerica and use multiple transcriptomes to determine gene use across life-cycle stages. Medusa, planula larva and polyp are each characterised by distinct transcriptome signatures reflecting abrupt life cycle transitions, and all deploy a mixture of phylogenetically old and new genes. Medusa specific transcription factors, including many with bilaterian orthologs, associate with diverse neurosensory structures. Compared to Clytia, the polyp-only hydrozoan Hydra has lost many of the medusa-expressed transcription factors, despite similar overall rates of gene content and sequence evolution. Absence of expression and gene loss among Clytia orthologs of genes patterning the anthozoan aboral pole, secondary axis and endomesoderm support simplification of planulae and polyps in Hydrozoa, including loss of bilateral symmetry. Consequently, although the polyp and planula are generally considered the ancestral cnidarian forms, in Clytia the medusa maximally deploys ancestral cnidarian–bilaterian transcription factor gene complexity.

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Posted July 20, 2018.
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The genome of the jellyfish Clytia hemisphaerica and the evolution of the cnidarian life-cycle
Lucas Leclère, Coralie Horin, Sandra Chevalier, Pascal Lapébie, Philippe Dru, Sophie Peron, Muriel Jager, Thomas Condamine, Karen Pottin, Séverine Romano, Julia Steger, Chiara Sinigaglia, Carine Barreau, Gonzalo Quiroga Artigas, Antonella Ruggiero, Cécile Fourrage, Johanna E. M. Kraus, Julie Poulain, Jean-Marc Aury, Patrick Wincker, Eric Quéinnec, Ulrich Technau, Michaël Manuel, Tsuyoshi Momose, Evelyn Houliston, Richard R. Copley
bioRxiv 369959; doi: https://doi.org/10.1101/369959
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The genome of the jellyfish Clytia hemisphaerica and the evolution of the cnidarian life-cycle
Lucas Leclère, Coralie Horin, Sandra Chevalier, Pascal Lapébie, Philippe Dru, Sophie Peron, Muriel Jager, Thomas Condamine, Karen Pottin, Séverine Romano, Julia Steger, Chiara Sinigaglia, Carine Barreau, Gonzalo Quiroga Artigas, Antonella Ruggiero, Cécile Fourrage, Johanna E. M. Kraus, Julie Poulain, Jean-Marc Aury, Patrick Wincker, Eric Quéinnec, Ulrich Technau, Michaël Manuel, Tsuyoshi Momose, Evelyn Houliston, Richard R. Copley
bioRxiv 369959; doi: https://doi.org/10.1101/369959

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