New Results
Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries
Jason Flannick, Josep M Mercader, Christian Fuchsberger, Miriam S Udler, Anubha Mahajan, Jennifer Wessel, Tanya M Teslovich, Lizz Caulkins, Ryan Koesterer, Thomas W Blackwell, Eric Boerwinkle, Jennifer A Brody, Ling Chen, Siying Chen, Cecilia Contreras-Cubas, Emilio Córdova, Adolfo Correa, Maria Cortes, Ralph A DeFronzo, Lawrence Dolan, Kimberly L Drews, Amanda Elliott, James S Floyd, Stacey Gabriel, Maria Eugenia Garay-Sevilla, Humberto García-Ortiz, Myron Gross, Sohee Han, Sarah Hanks, Nancy L Heard-Costa, Anne U Jackson, Marit E Jørgensen, Hyun Min Kang, Megan Kelsey, Bong-Jo Kim, Heikki A Koistinen, Johanna Kuusisto, Joseph B Leader, Allan Linneberg, Ching-Ti Liu, Jianjun Liu, Valeriya Lyssenko, Alisa K Manning, Anthony Marcketta, Juan Manuel Malacara-Hernandez, Angélica Martínez-Hernández, Karen Matsuo, Elizabeth Mayer-Davis, Elvia Mendoza-Caamal, Karen L Mohlke, Alanna C Morrison, Anne Ndungu, Maggie CY Ng, Colm O’Dushlaine, Anthony J Payne, Catherine Pihoker, Broad Genomics Platform, Wendy S Post, Michael Preuss, Bruce M Psaty, Ramachandran S Vasan, N William Rayner, Alexander P Reiner, Cristina Revilla-Monsalve, Neil R Robertson, Nicola Santoro, Claudia Schurmann, Wing Yee So, Heather M Stringham, Tim M Strom, Claudia HT Tam, Farook Thameem, Brian Tomlinson, Jason M Torres, Russell P Tracy, Rob M van Dam, Marijana Vujkovic, Shuai Wang, Ryan P Welch, Daniel R Witte, Tien-Yin Wong, Gil Atzmon, Nir Barzilai, John Blangero, Lori L Bonnycastle, Donald W Bowden, John C Chambers, Edmund Chan, Ching-Yu Cheng, Yoon Cho Shin, Francis S Collins, Paul S de Vries, Ravindranath Duggirala, Benjamin Glaser, Clicerio Gonzalez, Ma Elena Gonzalez, Leif Groop, Jaspal Singh Kooner, Soo Heon Kwak, Markku Laakso, Donna M Lehman, Peter Nilsson, Timothy D Spector, E Shyong Tai, Tiinamaija Tuomi, Jaakko Tuomilehto, James G Wilson, Carlos A Aguilar-Salinas, Erwin Bottinger, Brian Burke, David J Carey, Juliana Chan, Josée Dupuis, Philippe Frossard, Susan R Heckbert, Mi Yeong Hwang, Young Jin Kim, H Lester Kirchner, Jong-Young Lee, Juyoung Lee, Ruth Loos, Ronald CW Ma, Andrew D Morris, Christopher J O’Donnell, Colin NA Palmer, James Pankow, Kyong Soo Park, Asif Rasheed, Danish Saleheen, Xueling Sim, Kerrin S Small, Yik Ying Teo, Christopher Haiman, Craig L Hanis, Brian E Henderson, Lorena Orozco, Teresa Tusié-Luna, Frederick E Dewey, Aris Baras, Christian Gieger, Thomas Meitinger, Konstantin Strauch, Leslie Lange, Niels Grarup, Torben Hansen, Oluf Pedersen, Phil Zeitler, Dana Dabelea, Goncalo Abecasis, Graeme I Bell, Nancy J Cox, Mark Seielstad, Rob Sladek, James B Meigs, Steve Rich, Jerome I Rotter, DiscovEHR Collaboration, CHARGE, LuCamp, ProDiGY, GoT2D, ESP, SIGMA-T2D, T2D-GENES, AMP-T2D-GENES, David Altshuler, Noёl P Burtt, Laura J Scott, Andrew P Morris, Jose C Florez, Mark I McCarthy, Michael Boehnke
doi: https://doi.org/10.1101/371450
Jason Flannick
1Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
2Division of Genetics and Genomics, Boston Children’s Hospital, Boston, Massachusetts, USA.
Josep M Mercader
1Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
3Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Christian Fuchsberger
4Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
5Institute for Biomedicine, Eurac Research, Bolzano, Italy.
Miriam S Udler
1Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
6Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Anubha Mahajan
7Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
8Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Jennifer Wessel
9Department of Epidemiology, Fairbanks School of Public Health, Indiana University, Indianapolis, IN, 46202, US.
10Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN, 46202, US.
11Diabetes Translational Research Center, Indiana University, Indianapolis, IN, 46202, US.
Tanya M Teslovich
12Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, 10591, USA.
Lizz Caulkins
1Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Ryan Koesterer
1Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Thomas W Blackwell
4Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Eric Boerwinkle
13Human Genetics Center, Department of Epidemiology Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
14Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.
Jennifer A Brody
15Cardiovascular Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Ling Chen
6Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Siying Chen
4Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Cecilia Contreras-Cubas
16Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Emilio Córdova
16Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Adolfo Correa
17Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Maria Cortes
18Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Ralph A DeFronzo
19Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA.
Lawrence Dolan
20Cincinnati Children’s Hospital Medical Center, Ohio, Cincinnati, USA.
Kimberly L Drews
21Biostatistics Center, George Washington University, Rockville, MD, USA.
Amanda Elliott
1Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
6Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
James S Floyd
22Department of Medicine and Epidemiology, University of Washington, Seattle, WA, USA.
Stacey Gabriel
18Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Maria Eugenia Garay-Sevilla
23Departments of Medicine and Human Genetics, The University of Chicago, Chicago, Illinois, USA.
Humberto García-Ortiz
16Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Myron Gross
24Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
Sohee Han
25Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.
Sarah Hanks
4Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Nancy L Heard-Costa
26Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
27National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA.
Anne U Jackson
4Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Marit E Jørgensen
28Steno Diabetes Center Copenhagen, Gentofte, Denmark.
29National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
30Greenland Centre for Health Research, University of Greenland, Nuuk, Greenland.
Hyun Min Kang
4Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Megan Kelsey
21Biostatistics Center, George Washington University, Rockville, MD, USA.
Bong-Jo Kim
25Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.
Heikki A Koistinen
31Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
32University of Helsinki and Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
33Minerva Foundation Institute for Medical Research, Helsinki, Finland.
Johanna Kuusisto
34Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
35Department of Medicin, Kuopio University Hospital, Kuopio, Finland.
Joseph B Leader
36Geisinger Health System, Danville, PA, 17822, USA.
Allan Linneberg
37Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
38Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.
39Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark.
Ching-Ti Liu
40Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Jianjun Liu
41Genome Institute of Singapore, Agency for Science Technology and Research, Singapore.
42Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.
43Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Valeriya Lyssenko
44Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
45University of Bergen, Norway.
Alisa K Manning
46Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
47Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Anthony Marcketta
12Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, 10591, USA.
Juan Manuel Malacara-Hernandez
23Departments of Medicine and Human Genetics, The University of Chicago, Chicago, Illinois, USA.
Angélica Martínez-Hernández
16Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Karen Matsuo
4Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Elizabeth Mayer-Davis
48University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA.
Elvia Mendoza-Caamal
16Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Karen L Mohlke
49Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Alanna C Morrison
50Human Genetics Center, Department of Epidemiology Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Anne Ndungu
7Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Maggie CY Ng
51Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
52Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
53Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Colm O’Dushlaine
12Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, 10591, USA.
Anthony J Payne
7Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Catherine Pihoker
54Seattle Children’s Hospital, Washington, Seattle, USA.
18Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Wendy S Post
55Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Michael Preuss
56Charles R. Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, New York, USA.
Bruce M Psaty
57Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, Washington, USA.
58Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
Ramachandran S Vasan
27National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA.
59Preventive Medicine & Epidemiology, Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
N William Rayner
7Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
8Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
60Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.
Alexander P Reiner
61University of Washington, Seattle, Washington, USA.
Cristina Revilla-Monsalve
62Instituto Mexicano del Seguro Social SXXI, Mexico City, Mexico.
Neil R Robertson
7Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
8Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Nicola Santoro
63Department of Pediatrics, Yale University, New Haven, CT, USA.
Claudia Schurmann
56Charles R. Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, New York, USA.
Wing Yee So
64Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
65Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
66Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.
Heather M Stringham
4Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Tim M Strom
67Institute of Human Genetics, Technische Universität München, Munich, Germany.
68Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Claudia HT Tam
64Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
65Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
66Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.
Farook Thameem
69Department of Biochemistry, Faculty of Medicine, Health Science Center, Kuwait University, Safat, Kuwait.
Brian Tomlinson
64Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Jason M Torres
7Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Russell P Tracy
70Department of Pathology and Laboratory Medicine, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, Vermont, USA.
71Department of Biochemistry, Robert Larner M.D. College of Medicine, University of Vermont, Burlington, Vermont, USA.
Rob M van Dam
42Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.
43Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
72Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
Marijana Vujkovic
73Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Shuai Wang
40Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Ryan P Welch
4Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Daniel R Witte
74Department of Public Health, Aarhus University, Aarhus, Denmark.
75Danish Diabetes Academy, Odense, Denmark.
Tien-Yin Wong
76Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
77Duke-NUS Medical School Singapore, Singapore.
78Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.
Gil Atzmon
79Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, USA.
80University of Haifa, Faculty of natural science, Haifa, Isarel.
Nir Barzilai
79Departments of Medicine and Genetics, Albert Einstein College of Medicine, New York, USA.
John Blangero
81Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg and Brownsville, Texas, USA.
Lori L Bonnycastle
82Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Donald W Bowden
51Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
52Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
53Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
John C Chambers
83Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
84Department of Cardiology, Ealing Hospital NHS Trust, Southall, Middlesex, UK.
85Imperial College Healthcare NHS Trust, Imperial College London, London, UK.
Edmund Chan
42Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.
Ching-Yu Cheng
86Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore
Yoon Cho Shin
87Department of Biomedical Science, Hallym University, Chuncheon, Republic of Korea.
Francis S Collins
82Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Paul S de Vries
50Human Genetics Center, Department of Epidemiology Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Ravindranath Duggirala
81Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg and Brownsville, Texas, USA.
Benjamin Glaser
88Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Clicerio Gonzalez
89Unidad de Diabetes y Riesgo Cardiovascular, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico.
Ma Elena Gonzalez
90Centro de Estudios en Diabetes, Mexico City, Mexico.
Leif Groop
44Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
91Institute for Molecular Genetics Finland, University of Helsinki, Helsinki, Finland.
Jaspal Singh Kooner
92National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK.
Soo Heon Kwak
93Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Markku Laakso
34Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
35Department of Medicin, Kuopio University Hospital, Kuopio, Finland.
Donna M Lehman
19Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA.
Peter Nilsson
94Department of Clinical Sciences, Medicine, Lund University, Malmö, Sweden.
Timothy D Spector
95Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.
E Shyong Tai
42Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.
43Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
77Duke-NUS Medical School Singapore, Singapore.
Tiinamaija Tuomi
91Institute for Molecular Genetics Finland, University of Helsinki, Helsinki, Finland.
96Folkhälsan Research Centre, Helsinki, Finland.
97Department of Endocrinology, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland.
98Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
Jaakko Tuomilehto
99Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
100Center for Vascular Prevention, Danube University Krems, Krems, Austria.
101Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.
102Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), University Hospital LaPaz, Autonomous University of Madrid, Madrid, Spain.
James G Wilson
103Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Carlos A Aguilar-Salinas
104Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico.
Erwin Bottinger
56Charles R. Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, New York, USA.
Brian Burke
21Biostatistics Center, George Washington University, Rockville, MD, USA.
David J Carey
36Geisinger Health System, Danville, PA, 17822, USA.
Juliana Chan
64Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
65Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
66Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.
Josée Dupuis
27National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, USA.
40Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Philippe Frossard
105Center for Non-Communicable Diseases, Karachi, Pakistan.
Susan R Heckbert
106Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.
Mi Yeong Hwang
25Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.
Young Jin Kim
25Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.
H Lester Kirchner
36Geisinger Health System, Danville, PA, 17822, USA.
Jong-Young Lee
107Ministry of Health and Welfare, Seoul, Republic of Korea.
Juyoung Lee
25Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.
Ruth Loos
56Charles R. Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, New York, USA.
108The Mindich Child Health and Development Insititute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ronald CW Ma
64Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
65Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
66Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.
Andrew D Morris
109Clinical Research Centre, Centre for Molecular Medicine, Ninewells Hospital and Medical School, Dundee, UK.
Christopher J O’Donnell
110Section of Cardiology, Department of Medicine, VA Boston Healthcare, Boston, Massachusetts, USA.
111Harvard Medical School, Boston, Massachusetts, USA.
112Brigham and Women’s Hospital, Boston, Massachusetts, USA.
113Intramural Administration Management Branch, National Heart Lung and Blood Institute, NIH, Framingham, Massachusetts, USA.
Colin NA Palmer
114Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK.
James Pankow
115Division of Epidemiology and Community Health, University of Minnesota, Minnesota, MN, USA.
Kyong Soo Park
92National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK.
116Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea.
117Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Asif Rasheed
105Center for Non-Communicable Diseases, Karachi, Pakistan.
Danish Saleheen
73Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
105Center for Non-Communicable Diseases, Karachi, Pakistan.
Xueling Sim
43Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Kerrin S Small
95Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK.
Yik Ying Teo
43Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
118Life Sciences Institute, National University of Singapore, Singapore.
119Department of Statistics and Applied Probability, National University of Singapore, Singapore.
Christopher Haiman
120Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Craig L Hanis
121Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Brian E Henderson
120Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Lorena Orozco
16Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Teresa Tusié-Luna
104Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico.
122Instituto de Investigaciones Biomédicas, Departamento de Medicina Genómica y Toxicología, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Frederick E Dewey
12Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, 10591, USA.
Aris Baras
12Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, 10591, USA.
Christian Gieger
123Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
124German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Thomas Meitinger
67Institute of Human Genetics, Technische Universität München, Munich, Germany.
68Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
125Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
Konstantin Strauch
123Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
126Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Neuherberg, Germany.
Leslie Lange
127Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA.
Niels Grarup
128Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Torben Hansen
128Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
129Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Oluf Pedersen
128Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Phil Zeitler
21Biostatistics Center, George Washington University, Rockville, MD, USA.
Dana Dabelea
130Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA.
Goncalo Abecasis
4Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Graeme I Bell
23Departments of Medicine and Human Genetics, The University of Chicago, Chicago, Illinois, USA.
Nancy J Cox
131Vanderbilt Genetics Institute, Vanderbilt University, Tennessee, Nashville, USA.
Mark Seielstad
132Department of Laboratory Medicine & Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA.
133Blood Systems Research Institute, San Francisco, California, USA.
Rob Sladek
134Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
135Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Quebec, Canada.
136McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.
James B Meigs
18Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
46Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
137Division of General Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Steve Rich
138Center for Public Health Genomics, University of Viriginia School of Medicine, Charlottesville, Virginia, USA.
Jerome I Rotter
139Departments of Pediatrics and Medicine, Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
12Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, 10591, USA.
36Geisinger Health System, Danville, PA, 17822, USA.
David Altshuler
1Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
6Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
46Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
140Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
141Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
142Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Noёl P Burtt
1Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Laura J Scott
4Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Andrew P Morris
7Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
143Department of Biostatistics, University of Liverpool, Liverpool, UK.
Jose C Florez
1Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
6Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
46Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
144Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Mark I McCarthy
7Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
8Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
145Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK.
Michael Boehnke
4Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Posted July 31, 2018.
Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries
Jason Flannick, Josep M Mercader, Christian Fuchsberger, Miriam S Udler, Anubha Mahajan, Jennifer Wessel, Tanya M Teslovich, Lizz Caulkins, Ryan Koesterer, Thomas W Blackwell, Eric Boerwinkle, Jennifer A Brody, Ling Chen, Siying Chen, Cecilia Contreras-Cubas, Emilio Córdova, Adolfo Correa, Maria Cortes, Ralph A DeFronzo, Lawrence Dolan, Kimberly L Drews, Amanda Elliott, James S Floyd, Stacey Gabriel, Maria Eugenia Garay-Sevilla, Humberto García-Ortiz, Myron Gross, Sohee Han, Sarah Hanks, Nancy L Heard-Costa, Anne U Jackson, Marit E Jørgensen, Hyun Min Kang, Megan Kelsey, Bong-Jo Kim, Heikki A Koistinen, Johanna Kuusisto, Joseph B Leader, Allan Linneberg, Ching-Ti Liu, Jianjun Liu, Valeriya Lyssenko, Alisa K Manning, Anthony Marcketta, Juan Manuel Malacara-Hernandez, Angélica Martínez-Hernández, Karen Matsuo, Elizabeth Mayer-Davis, Elvia Mendoza-Caamal, Karen L Mohlke, Alanna C Morrison, Anne Ndungu, Maggie CY Ng, Colm O’Dushlaine, Anthony J Payne, Catherine Pihoker, Broad Genomics Platform, Wendy S Post, Michael Preuss, Bruce M Psaty, Ramachandran S Vasan, N William Rayner, Alexander P Reiner, Cristina Revilla-Monsalve, Neil R Robertson, Nicola Santoro, Claudia Schurmann, Wing Yee So, Heather M Stringham, Tim M Strom, Claudia HT Tam, Farook Thameem, Brian Tomlinson, Jason M Torres, Russell P Tracy, Rob M van Dam, Marijana Vujkovic, Shuai Wang, Ryan P Welch, Daniel R Witte, Tien-Yin Wong, Gil Atzmon, Nir Barzilai, John Blangero, Lori L Bonnycastle, Donald W Bowden, John C Chambers, Edmund Chan, Ching-Yu Cheng, Yoon Cho Shin, Francis S Collins, Paul S de Vries, Ravindranath Duggirala, Benjamin Glaser, Clicerio Gonzalez, Ma Elena Gonzalez, Leif Groop, Jaspal Singh Kooner, Soo Heon Kwak, Markku Laakso, Donna M Lehman, Peter Nilsson, Timothy D Spector, E Shyong Tai, Tiinamaija Tuomi, Jaakko Tuomilehto, James G Wilson, Carlos A Aguilar-Salinas, Erwin Bottinger, Brian Burke, David J Carey, Juliana Chan, Josée Dupuis, Philippe Frossard, Susan R Heckbert, Mi Yeong Hwang, Young Jin Kim, H Lester Kirchner, Jong-Young Lee, Juyoung Lee, Ruth Loos, Ronald CW Ma, Andrew D Morris, Christopher J O’Donnell, Colin NA Palmer, James Pankow, Kyong Soo Park, Asif Rasheed, Danish Saleheen, Xueling Sim, Kerrin S Small, Yik Ying Teo, Christopher Haiman, Craig L Hanis, Brian E Henderson, Lorena Orozco, Teresa Tusié-Luna, Frederick E Dewey, Aris Baras, Christian Gieger, Thomas Meitinger, Konstantin Strauch, Leslie Lange, Niels Grarup, Torben Hansen, Oluf Pedersen, Phil Zeitler, Dana Dabelea, Goncalo Abecasis, Graeme I Bell, Nancy J Cox, Mark Seielstad, Rob Sladek, James B Meigs, Steve Rich, Jerome I Rotter, DiscovEHR Collaboration, CHARGE, LuCamp, ProDiGY, GoT2D, ESP, SIGMA-T2D, T2D-GENES, AMP-T2D-GENES, David Altshuler, Noёl P Burtt, Laura J Scott, Andrew P Morris, Jose C Florez, Mark I McCarthy, Michael Boehnke
bioRxiv 371450; doi: https://doi.org/10.1101/371450
Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries
Jason Flannick, Josep M Mercader, Christian Fuchsberger, Miriam S Udler, Anubha Mahajan, Jennifer Wessel, Tanya M Teslovich, Lizz Caulkins, Ryan Koesterer, Thomas W Blackwell, Eric Boerwinkle, Jennifer A Brody, Ling Chen, Siying Chen, Cecilia Contreras-Cubas, Emilio Córdova, Adolfo Correa, Maria Cortes, Ralph A DeFronzo, Lawrence Dolan, Kimberly L Drews, Amanda Elliott, James S Floyd, Stacey Gabriel, Maria Eugenia Garay-Sevilla, Humberto García-Ortiz, Myron Gross, Sohee Han, Sarah Hanks, Nancy L Heard-Costa, Anne U Jackson, Marit E Jørgensen, Hyun Min Kang, Megan Kelsey, Bong-Jo Kim, Heikki A Koistinen, Johanna Kuusisto, Joseph B Leader, Allan Linneberg, Ching-Ti Liu, Jianjun Liu, Valeriya Lyssenko, Alisa K Manning, Anthony Marcketta, Juan Manuel Malacara-Hernandez, Angélica Martínez-Hernández, Karen Matsuo, Elizabeth Mayer-Davis, Elvia Mendoza-Caamal, Karen L Mohlke, Alanna C Morrison, Anne Ndungu, Maggie CY Ng, Colm O’Dushlaine, Anthony J Payne, Catherine Pihoker, Broad Genomics Platform, Wendy S Post, Michael Preuss, Bruce M Psaty, Ramachandran S Vasan, N William Rayner, Alexander P Reiner, Cristina Revilla-Monsalve, Neil R Robertson, Nicola Santoro, Claudia Schurmann, Wing Yee So, Heather M Stringham, Tim M Strom, Claudia HT Tam, Farook Thameem, Brian Tomlinson, Jason M Torres, Russell P Tracy, Rob M van Dam, Marijana Vujkovic, Shuai Wang, Ryan P Welch, Daniel R Witte, Tien-Yin Wong, Gil Atzmon, Nir Barzilai, John Blangero, Lori L Bonnycastle, Donald W Bowden, John C Chambers, Edmund Chan, Ching-Yu Cheng, Yoon Cho Shin, Francis S Collins, Paul S de Vries, Ravindranath Duggirala, Benjamin Glaser, Clicerio Gonzalez, Ma Elena Gonzalez, Leif Groop, Jaspal Singh Kooner, Soo Heon Kwak, Markku Laakso, Donna M Lehman, Peter Nilsson, Timothy D Spector, E Shyong Tai, Tiinamaija Tuomi, Jaakko Tuomilehto, James G Wilson, Carlos A Aguilar-Salinas, Erwin Bottinger, Brian Burke, David J Carey, Juliana Chan, Josée Dupuis, Philippe Frossard, Susan R Heckbert, Mi Yeong Hwang, Young Jin Kim, H Lester Kirchner, Jong-Young Lee, Juyoung Lee, Ruth Loos, Ronald CW Ma, Andrew D Morris, Christopher J O’Donnell, Colin NA Palmer, James Pankow, Kyong Soo Park, Asif Rasheed, Danish Saleheen, Xueling Sim, Kerrin S Small, Yik Ying Teo, Christopher Haiman, Craig L Hanis, Brian E Henderson, Lorena Orozco, Teresa Tusié-Luna, Frederick E Dewey, Aris Baras, Christian Gieger, Thomas Meitinger, Konstantin Strauch, Leslie Lange, Niels Grarup, Torben Hansen, Oluf Pedersen, Phil Zeitler, Dana Dabelea, Goncalo Abecasis, Graeme I Bell, Nancy J Cox, Mark Seielstad, Rob Sladek, James B Meigs, Steve Rich, Jerome I Rotter, DiscovEHR Collaboration, CHARGE, LuCamp, ProDiGY, GoT2D, ESP, SIGMA-T2D, T2D-GENES, AMP-T2D-GENES, David Altshuler, Noёl P Burtt, Laura J Scott, Andrew P Morris, Jose C Florez, Mark I McCarthy, Michael Boehnke
bioRxiv 371450; doi: https://doi.org/10.1101/371450
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