Plasmodium falciparum Niemann-Pick Type C1-Related Protein is a Druggable Target Required for Parasite Membrane Homeostasis

Eva S. Istvan; Sudipta Das; Suyash Bhatnagar; Josh R. Beck; Edward Owen; Manuel Llinás; Suresh M. Ganesan; Jacquin C. Niles; Elizabeth A. Winzeler; Akhil B. Vaidya; Daniel E. Goldberg

doi:10.1101/371484

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Plasmodium falciparum Niemann-Pick Type C1-Related Protein is a Druggable Target Required for Parasite Membrane Homeostasis

Eva S. Istvan, Sudipta Das, Suyash Bhatnagar, Josh R. Beck, Edward Owen, Manuel Llinás, Suresh M. Ganesan, Jacquin C. Niles, Elizabeth A. Winzeler, Akhil B. Vaidya, Daniel E. Goldberg

doi: https://doi.org/10.1101/371484

Eva S. Istvan

1Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, Saint Louis, Missouri 63110, USA

2Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA

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Sudipta Das

3Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102

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Suyash Bhatnagar

3Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102

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Josh R. Beck

1Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, Saint Louis, Missouri 63110, USA

2Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA

4Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011

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Edward Owen

5Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, and Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA

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Manuel Llinás

5Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, and Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA

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Suresh M. Ganesan

6Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

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Jacquin C. Niles

6Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

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Elizabeth A. Winzeler

7Department of Pediatrics, School of Medicine, University of California San Diego School of Medicine, La Jolla, California 92093, USA

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Akhil B. Vaidya

3Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102

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Daniel E. Goldberg

1Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, Saint Louis, Missouri 63110, USA

2Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA

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Posted July 18, 2018.

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Plasmodium falciparum Niemann-Pick Type C1-Related Protein is a Druggable Target Required for Parasite Membrane Homeostasis

Eva S. Istvan, Sudipta Das, Suyash Bhatnagar, Josh R. Beck, Edward Owen, Manuel Llinás, Suresh M. Ganesan, Jacquin C. Niles, Elizabeth A. Winzeler, Akhil B. Vaidya, Daniel E. Goldberg

bioRxiv 371484; doi: https://doi.org/10.1101/371484

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Plasmodium falciparum Niemann-Pick Type C1-Related Protein is a Druggable Target Required for Parasite Membrane Homeostasis

Eva S. Istvan, Sudipta Das, Suyash Bhatnagar, Josh R. Beck, Edward Owen, Manuel Llinás, Suresh M. Ganesan, Jacquin C. Niles, Elizabeth A. Winzeler, Akhil B. Vaidya, Daniel E. Goldberg

bioRxiv 371484; doi: https://doi.org/10.1101/371484

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