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Oxytocin modulates the intrinsic dynamics between attention-related large scale networks

Fei Xin, Feng Zhou, Xinqi Zhou, Xiaole Ma, Yayuan Geng, Weihua Zhao, Shuxia Yao, Debo Dong, Bharat B. Biswal, Keith M. Kendrick, Benjamin Becker
doi: https://doi.org/10.1101/371971
Fei Xin
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
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Feng Zhou
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
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Xinqi Zhou
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
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Xiaole Ma
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
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Yayuan Geng
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
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Weihua Zhao
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
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Shuxia Yao
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
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Debo Dong
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
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Bharat B. Biswal
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA
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Keith M. Kendrick
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
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Benjamin Becker
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China
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  • For correspondence: ben_becker@gmx.de
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Abstract

Attention and salience processing have been linked to the intrinsic between- and within-network dynamics of large scale networks engaged in internal (default mode network, DN) and external attention allocation (dorsal attention, DAN, salience network, SN). The central oxytocin (OXT) system appears ideally organized to modulate widely distributed neural systems and to regulate the switch between internal attention and salient stimuli in the environment. The current randomized placebo (PLC) controlled between-subject pharmacological resting-state fMRI study in N = 187 (OXT, n = 94; n = 93; single-dose intranasal administration) healthy male and female participants employed an independent component analysis (ICA) approach to determine the modulatory effects of OXT on the within- and between-network dynamics of the DAN-SN-DN triple network system. OXT increased the functional integration between subsystems within SN and DN and increased functional segregation of the DN with the SN and DAN engaged in attentional control. Whereas no sex differences were observed, OXT effects on the DN-SN interaction were modulated by autism traits. Together, the findings suggest that OXT may facilitate efficient attentional allocation towards social cues by modulating the intrinsic functional dynamics between DN components engaged in social processing and large-scale networks involved in external attentional demands (SN, DAN).

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Posted July 19, 2018.
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Oxytocin modulates the intrinsic dynamics between attention-related large scale networks
Fei Xin, Feng Zhou, Xinqi Zhou, Xiaole Ma, Yayuan Geng, Weihua Zhao, Shuxia Yao, Debo Dong, Bharat B. Biswal, Keith M. Kendrick, Benjamin Becker
bioRxiv 371971; doi: https://doi.org/10.1101/371971
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Oxytocin modulates the intrinsic dynamics between attention-related large scale networks
Fei Xin, Feng Zhou, Xinqi Zhou, Xiaole Ma, Yayuan Geng, Weihua Zhao, Shuxia Yao, Debo Dong, Bharat B. Biswal, Keith M. Kendrick, Benjamin Becker
bioRxiv 371971; doi: https://doi.org/10.1101/371971

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