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Targeting hepatitis C virus p7 channel activity reveals prospect for bimodal antiviral prophylaxis

Joseph Shaw, Rajendra Gosein, Monoj Mon Kalita, Jayakanth Kankanala, D. Ram Mahato, Toshana Foster, Claire Scott, Matthew Bentham, Laura Wetherill, Abigail Bloy, Adel Samson, Mark Harris, Andrew Macdonald, David Rowlands, Jamel Mankouri, Wolfgang Fischer, Richard Foster, View ORCID ProfileStephen Griffin
doi: https://doi.org/10.1101/374793
Joseph Shaw
School of Medicine, Faculty of Medicine and Health, University of Leeds, St James’ University Hospital, Beckett St., Leeds, LS9 7TF, United KingdomAstbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom
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Rajendra Gosein
School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United KingdomAstbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom
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Monoj Mon Kalita
Institute of Biophotonics, National Yang-Ming University, Taipei, Taiwan
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Jayakanth Kankanala
School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United KingdomAstbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom
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D. Ram Mahato
Institute of Biophotonics, National Yang-Ming University, Taipei, Taiwan
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Toshana Foster
School of Medicine, Faculty of Medicine and Health, University of Leeds, St James’ University Hospital, Beckett St., Leeds, LS9 7TF, United KingdomAstbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom
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Claire Scott
School of Medicine, Faculty of Medicine and Health, University of Leeds, St James’ University Hospital, Beckett St., Leeds, LS9 7TF, United KingdomAstbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom
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Matthew Bentham
School of Medicine, Faculty of Medicine and Health, University of Leeds, St James’ University Hospital, Beckett St., Leeds, LS9 7TF, United KingdomAstbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom
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Laura Wetherill
School of Medicine, Faculty of Medicine and Health, University of Leeds, St James’ University Hospital, Beckett St., Leeds, LS9 7TF, United KingdomAstbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom
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Abigail Bloy
School of Medicine, Faculty of Medicine and Health, University of Leeds, St James’ University Hospital, Beckett St., Leeds, LS9 7TF, United KingdomAstbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom
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Adel Samson
School of Medicine, Faculty of Medicine and Health, University of Leeds, St James’ University Hospital, Beckett St., Leeds, LS9 7TF, United Kingdom
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Mark Harris
Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United KingdomSchool of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom
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Andrew Macdonald
Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United KingdomSchool of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom
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David Rowlands
Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United KingdomSchool of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom
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Jamel Mankouri
Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United KingdomSchool of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom
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Wolfgang Fischer
Institute of Biophotonics, National Yang-Ming University, Taipei, Taiwan
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Richard Foster
School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United KingdomAstbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom
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  • For correspondence: s.d.c.griffin@leeds.ac.uk R.Foster@leeds.ac.uk
Stephen Griffin
School of Medicine, Faculty of Medicine and Health, University of Leeds, St James’ University Hospital, Beckett St., Leeds, LS9 7TF, United KingdomAstbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom
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  • ORCID record for Stephen Griffin
  • For correspondence: s.d.c.griffin@leeds.ac.uk R.Foster@leeds.ac.uk
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Posted July 23, 2018.
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Targeting hepatitis C virus p7 channel activity reveals prospect for bimodal antiviral prophylaxis
Joseph Shaw, Rajendra Gosein, Monoj Mon Kalita, Jayakanth Kankanala, D. Ram Mahato, Toshana Foster, Claire Scott, Matthew Bentham, Laura Wetherill, Abigail Bloy, Adel Samson, Mark Harris, Andrew Macdonald, David Rowlands, Jamel Mankouri, Wolfgang Fischer, Richard Foster, Stephen Griffin
bioRxiv 374793; doi: https://doi.org/10.1101/374793
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Targeting hepatitis C virus p7 channel activity reveals prospect for bimodal antiviral prophylaxis
Joseph Shaw, Rajendra Gosein, Monoj Mon Kalita, Jayakanth Kankanala, D. Ram Mahato, Toshana Foster, Claire Scott, Matthew Bentham, Laura Wetherill, Abigail Bloy, Adel Samson, Mark Harris, Andrew Macdonald, David Rowlands, Jamel Mankouri, Wolfgang Fischer, Richard Foster, Stephen Griffin
bioRxiv 374793; doi: https://doi.org/10.1101/374793

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