Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Extracellular matrix regulates morphogenesis and function of ciliated sensory organs in Caenorhabditis elegans

Deanna M. De Vore, Karla M. Knobel, Ken C.Q. Nguyen, David H. Hall, View ORCID ProfileMaureen M. Barr
doi: https://doi.org/10.1101/376152
Deanna M. De Vore
*Department of Genetics and Human Genetics Institute of New Jersey, Rutgers, The State University of NJ, Piscataway, NJ 08854
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Karla M. Knobel
‡University of Wisconsin-Madison, Madison, WI 53706
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ken C.Q. Nguyen
†C. elegans, Bronx, NY 10461
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David H. Hall
†C. elegans, Bronx, NY 10461
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maureen M. Barr
*Department of Genetics and Human Genetics Institute of New Jersey, Rutgers, The State University of NJ, Piscataway, NJ 08854
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Maureen M. Barr
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

ABSTRACT

Cilia and extracellular vesicles (EVs) are signaling organelles that play important roles in human health and disease. In C. elegans and mammals, the Autosomal Dominant Polycystic Kidney Disease (ADPKD) gene products polycystin-1 and polycystin-2 localize to both cilia and EVs, act in the same genetic pathway, and function in a sensory capacity, suggesting ancient conservation. Hence, the nematode offers an excellent system in which to address central questions regarding the biology of cilia, EVs, and the polycystins. We discovered an unexpected role of the mec-1, mec-5, and mec-9 genes encoding extracellular matrix (ECM) components. We determined that these ECM encoding genes regulate polycystin localization and function, ciliary EV release, cilia length, dendritic morphology, and neuron-glia interactions. Abnormal ECM and fibrosis are observed in ciliopathies such as ADPKD, nephronophthisis, and Bardet-Biedl Syndrome. Our studies reveal multifaceted roles for ECM proteins in the ciliated nervous system of the worm and provide a powerful new in vivo model to study the relationship between ECM, the polycystins, and ciliopathies.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted July 24, 2018.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Extracellular matrix regulates morphogenesis and function of ciliated sensory organs in Caenorhabditis elegans
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Extracellular matrix regulates morphogenesis and function of ciliated sensory organs in Caenorhabditis elegans
Deanna M. De Vore, Karla M. Knobel, Ken C.Q. Nguyen, David H. Hall, Maureen M. Barr
bioRxiv 376152; doi: https://doi.org/10.1101/376152
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Extracellular matrix regulates morphogenesis and function of ciliated sensory organs in Caenorhabditis elegans
Deanna M. De Vore, Karla M. Knobel, Ken C.Q. Nguyen, David H. Hall, Maureen M. Barr
bioRxiv 376152; doi: https://doi.org/10.1101/376152

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Cell Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4847)
  • Biochemistry (10781)
  • Bioengineering (8035)
  • Bioinformatics (27263)
  • Biophysics (13967)
  • Cancer Biology (11115)
  • Cell Biology (16035)
  • Clinical Trials (138)
  • Developmental Biology (8773)
  • Ecology (13270)
  • Epidemiology (2067)
  • Evolutionary Biology (17346)
  • Genetics (11681)
  • Genomics (15905)
  • Immunology (11015)
  • Microbiology (26054)
  • Molecular Biology (10628)
  • Neuroscience (56486)
  • Paleontology (417)
  • Pathology (1729)
  • Pharmacology and Toxicology (3000)
  • Physiology (4539)
  • Plant Biology (9618)
  • Scientific Communication and Education (1613)
  • Synthetic Biology (2685)
  • Systems Biology (6970)
  • Zoology (1508)