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Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation
Jamie A. Macpherson, Alina Theisen, Laura Masino, Louise Fets, Paul C. Driscoll, Vesela Encheva, Ambrosius P. Snijders, Stephen R. Martin, Jens Kleinjung, View ORCID ProfilePerdita E. Barran, View ORCID ProfileFranca Fraternali, View ORCID ProfileDimitrios Anastasiou
doi: https://doi.org/10.1101/378133
Jamie A. Macpherson
1Cancer Metabolism Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, United Kingdom
7Randall Centre for Cell and Molecular Biophysics, King’s College London, UK
Alina Theisen
6Michael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester UK
Laura Masino
2Structural Biology Science Technology Platform, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, United Kingdom
Louise Fets
1Cancer Metabolism Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, United Kingdom
Paul C. Driscoll
3Metabolomics Science Technology Platform, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, United Kingdom
Vesela Encheva
4Proteomics Science Technology Platform, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, United Kingdom
Ambrosius P. Snijders
4Proteomics Science Technology Platform, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, United Kingdom
Stephen R. Martin
2Structural Biology Science Technology Platform, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, United Kingdom
Jens Kleinjung
5Computational Biology Science Technology Platform, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, United Kingdom
Perdita E. Barran
6Michael Barber Centre for Collaborative Mass Spectrometry, Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester UK
Franca Fraternali
7Randall Centre for Cell and Molecular Biophysics, King’s College London, UK
Dimitrios Anastasiou
1Cancer Metabolism Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, United Kingdom
Article usage
Posted July 26, 2018.
Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation
Jamie A. Macpherson, Alina Theisen, Laura Masino, Louise Fets, Paul C. Driscoll, Vesela Encheva, Ambrosius P. Snijders, Stephen R. Martin, Jens Kleinjung, Perdita E. Barran, Franca Fraternali, Dimitrios Anastasiou
bioRxiv 378133; doi: https://doi.org/10.1101/378133
Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation
Jamie A. Macpherson, Alina Theisen, Laura Masino, Louise Fets, Paul C. Driscoll, Vesela Encheva, Ambrosius P. Snijders, Stephen R. Martin, Jens Kleinjung, Perdita E. Barran, Franca Fraternali, Dimitrios Anastasiou
bioRxiv 378133; doi: https://doi.org/10.1101/378133
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