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Quantitative comparison of the anterior-posterior patterning system in the embryos of five Drosophila species

View ORCID ProfileZeba Wunderlich, Charless C. Fowlkes, Kelly B. Eckenrode, View ORCID ProfileMeghan D. J. Bragdon, Arash Abiri, View ORCID ProfileAngela H. DePace
doi: https://doi.org/10.1101/378430
Zeba Wunderlich
University of California, Irvine;
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Charless C. Fowlkes
University of California, Irvine;
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Kelly B. Eckenrode
Harvard Medical School
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Meghan D. J. Bragdon
Harvard Medical School
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Arash Abiri
University of California, Irvine;
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Angela H. DePace
Harvard Medical School
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Abstract

Complex spatiotemporal gene expression patterns direct the development of the fertilized egg into an adult animal. Comparisons across species show that, in spite of changes in the underlying regulatory DNA sequence, developmental programs can be maintained across millions of years of evolution. Reciprocally, changes in gene expression can be used to generate morphological novelty. Distinguishing between changes in regulatory DNA that lead to changes in gene expression and those that do not is therefore a central goal of evolutionary developmental biology. Quantitative, spatially-resolved measurements of developmental gene expression patterns play a crucial role in this goal, enabling the detection of subtle phenotypic differences between species and the development of computations models that link the sequence of regulatory DNA to expression patterns. Here we report the generation of two atlases of cellular resolution gene expression measurements for the primary anterior-posterior patterning genes in Drosophila simulans and Drosophila virilis. By combining these data sets with existing atlases for three other Drosophila species, we detect subtle differences in the gene expression patterns and dynamics driving the highly conserved axis patterning system and delineate inter-species differences in the embryonic morphology. These data sets will be a resource for future modeling studies of the evolution of developmental gene regulatory networks.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted July 29, 2018.
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Quantitative comparison of the anterior-posterior patterning system in the embryos of five Drosophila species
Zeba Wunderlich, Charless C. Fowlkes, Kelly B. Eckenrode, Meghan D. J. Bragdon, Arash Abiri, Angela H. DePace
bioRxiv 378430; doi: https://doi.org/10.1101/378430
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Quantitative comparison of the anterior-posterior patterning system in the embryos of five Drosophila species
Zeba Wunderlich, Charless C. Fowlkes, Kelly B. Eckenrode, Meghan D. J. Bragdon, Arash Abiri, Angela H. DePace
bioRxiv 378430; doi: https://doi.org/10.1101/378430

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