Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Phylodynamic analysis of the historical spread of Toscana virus around the Mediterranean

View ORCID ProfileM. Grazia Cusi, View ORCID ProfileClaudia Gandolfo, View ORCID ProfileGianni Gori Savellini, Chiara Terrosi, Rebecca A. Sadler, View ORCID ProfileDerek Gatherer
doi: https://doi.org/10.1101/380477
M. Grazia Cusi
1Section of Microbiology, Department of Medical Biotechnologies, Siena University School of Medicine, Siena, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Grazia Cusi
Claudia Gandolfo
1Section of Microbiology, Department of Medical Biotechnologies, Siena University School of Medicine, Siena, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Claudia Gandolfo
Gianni Gori Savellini
1Section of Microbiology, Department of Medical Biotechnologies, Siena University School of Medicine, Siena, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Gianni Gori Savellini
Chiara Terrosi
1Section of Microbiology, Department of Medical Biotechnologies, Siena University School of Medicine, Siena, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rebecca A. Sadler
2Division of Biomedical & Life Sciences, Faculty of Health & Medicine, Lancaster University, LA1 3SA, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Derek Gatherer
2Division of Biomedical & Life Sciences, Faculty of Health & Medicine, Lancaster University, LA1 3SA, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Derek Gatherer
  • For correspondence: d.gatherer@lancaster.ac.uk
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

All available sequences of the three genome segments of Toscana virus with date and location of sampling were analysed using Bayesian phylodynamic methods. We estimate that extant Toscana virus strains had a common ancestor in the late 16th to early 17th century AD, in territories controlled by the Ottoman Empire, giving rise to an ancestral genotype A/B in north Africa and to genotype C in the Balkans. Subsequent spread into western Europe may have occurred during the period of European colonization of north Africa in the 19th and early 20th centuries AD, establishing genotypes A and B in Italy and Spain respectively. Very little positive evolutionary selection pressure is detectable in Toscana virus, suggesting that the virus has become well adapted to its human hosts. There is also no convincing evidence of reassortment between genome segments, despite genotypes A and B now co-circulating in several countries.

Footnotes

  • Other author emails: cusi{at}unisi.it claudia.gandolfo{at}unisi.it gianni.gori{at}unisi.it chiara.terrosi{at}unisi.it rebeccaannesadler{at}gmail.com

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted July 30, 2018.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Phylodynamic analysis of the historical spread of Toscana virus around the Mediterranean
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Phylodynamic analysis of the historical spread of Toscana virus around the Mediterranean
M. Grazia Cusi, Claudia Gandolfo, Gianni Gori Savellini, Chiara Terrosi, Rebecca A. Sadler, Derek Gatherer
bioRxiv 380477; doi: https://doi.org/10.1101/380477
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Phylodynamic analysis of the historical spread of Toscana virus around the Mediterranean
M. Grazia Cusi, Claudia Gandolfo, Gianni Gori Savellini, Chiara Terrosi, Rebecca A. Sadler, Derek Gatherer
bioRxiv 380477; doi: https://doi.org/10.1101/380477

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Microbiology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4119)
  • Biochemistry (8828)
  • Bioengineering (6532)
  • Bioinformatics (23484)
  • Biophysics (11805)
  • Cancer Biology (9223)
  • Cell Biology (13336)
  • Clinical Trials (138)
  • Developmental Biology (7442)
  • Ecology (11425)
  • Epidemiology (2066)
  • Evolutionary Biology (15173)
  • Genetics (10453)
  • Genomics (14056)
  • Immunology (9187)
  • Microbiology (22199)
  • Molecular Biology (8823)
  • Neuroscience (47626)
  • Paleontology (351)
  • Pathology (1431)
  • Pharmacology and Toxicology (2493)
  • Physiology (3736)
  • Plant Biology (8090)
  • Scientific Communication and Education (1438)
  • Synthetic Biology (2224)
  • Systems Biology (6042)
  • Zoology (1254)