Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Can transcranial electric stimulation with multiple electrodes reach deep targets?

Yu Huang, Lucas C. Parra
doi: https://doi.org/10.1101/382598
Yu Huang
aDepartment of Biomedical Engineering, City College of the City University of New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lucas C. Parra
aDepartment of Biomedical Engineering, City College of the City University of New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

To reach a deep target in the brain with transcranial electric stimulation (TES), currents have to pass also through the cortical surface. Thus, it is generally thought that TES cannot achieve focal deep brain stimulation. Recent efforts with interfering waveforms and pulsed stimulation have argued that one can achieve deeper or more intense stimulation in the brain. Here we argue that conventional transcranial stimulation with multiple current sources is just as effective as these new approaches. The conventional multi-electrode approach can be numerically optimized to maximize intensity or focality at a desired target location. Using such optimal electrode configurations we find in a detailed and realistic head model that deep targets may in fact be strongly stimulated, with cerebro-spinal fluid guiding currents deep into the brain.

Highlights
  • Deep targets can be reached with intensities comparable to the cortical surface.

  • Multi-electrode montages increase intensity with the same current limits per electrode.

  • High-definition and intersectional pulsed stimulation are largely equivalent.

  • Interferential stimulation is generally weaker than conventional stimulation.

Footnotes

  • ↵* parra{at}ccny.cuny.edu

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted August 01, 2018.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Can transcranial electric stimulation with multiple electrodes reach deep targets?
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Can transcranial electric stimulation with multiple electrodes reach deep targets?
Yu Huang, Lucas C. Parra
bioRxiv 382598; doi: https://doi.org/10.1101/382598
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Can transcranial electric stimulation with multiple electrodes reach deep targets?
Yu Huang, Lucas C. Parra
bioRxiv 382598; doi: https://doi.org/10.1101/382598

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Biophysics
Subject Areas
All Articles
  • Animal Behavior and Cognition (3573)
  • Biochemistry (7517)
  • Bioengineering (5478)
  • Bioinformatics (20671)
  • Biophysics (10254)
  • Cancer Biology (7927)
  • Cell Biology (11566)
  • Clinical Trials (138)
  • Developmental Biology (6563)
  • Ecology (10130)
  • Epidemiology (2065)
  • Evolutionary Biology (13532)
  • Genetics (9496)
  • Genomics (12788)
  • Immunology (7869)
  • Microbiology (19443)
  • Molecular Biology (7611)
  • Neuroscience (41862)
  • Paleontology (306)
  • Pathology (1252)
  • Pharmacology and Toxicology (2179)
  • Physiology (3249)
  • Plant Biology (7002)
  • Scientific Communication and Education (1291)
  • Synthetic Biology (1941)
  • Systems Biology (5405)
  • Zoology (1107)