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Behavioral response to visual motion impacts population coding in the mouse visual thalamus

View ORCID ProfileKarolina Socha, Matt Whiteway, View ORCID ProfileDaniel A. Butts, View ORCID ProfileVincent Bonin
doi: https://doi.org/10.1101/382671
Karolina Socha
1Neuro-Electronics Research Flanders, Leuven, Belgium
2Department of Biology & Leuven Brain Institute, Katholieke Universiteit Leuven, Leuven, Belgium
3Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium
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Matt Whiteway
4Applied Mathematics & Statistics, and Scientific Computation Program, University of Maryland, College Park, Maryland 20815, United States
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Daniel A. Butts
4Applied Mathematics & Statistics, and Scientific Computation Program, University of Maryland, College Park, Maryland 20815, United States
5Department of Biology and Program in Neuroscience and Cognitive Science, University of Maryland, College Park, Maryland 20815, United States
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Vincent Bonin
1Neuro-Electronics Research Flanders, Leuven, Belgium
2Department of Biology & Leuven Brain Institute, Katholieke Universiteit Leuven, Leuven, Belgium
3Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium
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  • For correspondence: vincent.bonin@nerf.be
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Summary

Visual motion is a ubiquitous component of animals’ sensory experience and its encoding is critical for navigation and movement. Yet its impact on behavior and neural coding is not well understood. Combining pupillometry with cellular calcium imaging measurements of thalamocortical axons in awake behaving mice, we examined the impact of arousal and behavioral state on encoding of visual motion in the visual thalamus. We discovered that back-to-front visual motions elicits a robust behavioral response that shapes tunings of visual thalamic responses. Consistent with an arousal mechanism, the effects were pronounced during stillness and weak or absent during locomotor activity and under anesthesia. The impact on neuronal tuning was specific, biasing population response patterns in favor of back-to-front motion. The potent influence of visual motion on behavioral state dynamically affect sensory coding at early visual processing stages. Further research is required to reveal the circuitry and function of this novel mechanism.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted August 01, 2018.
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Behavioral response to visual motion impacts population coding in the mouse visual thalamus
Karolina Socha, Matt Whiteway, Daniel A. Butts, Vincent Bonin
bioRxiv 382671; doi: https://doi.org/10.1101/382671
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Behavioral response to visual motion impacts population coding in the mouse visual thalamus
Karolina Socha, Matt Whiteway, Daniel A. Butts, Vincent Bonin
bioRxiv 382671; doi: https://doi.org/10.1101/382671

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