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Large-Scale plurimodal networks common to listening, production and reading word-lists: an fmri study combining tasks-induced activation and intrinsic connectivity in 144 right-handers

View ORCID ProfileI Hesling, View ORCID ProfileL Labache, View ORCID ProfileM Joliot, View ORCID ProfileN Tzourio-Mazoyer
doi: https://doi.org/10.1101/382960
I Hesling
1Univ. Bordeaux, IMN, UMR 5293, F-33000 Bordeaux, France
2CNRS, IMN, UMR 5293, F-33000 Bordeaux, France
3CEA, GIN, IMN, UMR 5293, F-33000 Bordeaux, France
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  • For correspondence: isabelle.hesling@u-bordeaux.fr
L Labache
1Univ. Bordeaux, IMN, UMR 5293, F-33000 Bordeaux, France
2CNRS, IMN, UMR 5293, F-33000 Bordeaux, France
3CEA, GIN, IMN, UMR 5293, F-33000 Bordeaux, France
4Univ. Bordeaux, IMB, UMR CNRS 5251, F-33405 Talence, France
5INRIA Bordeaux Sud-Ouest, CQFD, INRIA, UMR 5251, F-33405 Talence, France
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M Joliot
1Univ. Bordeaux, IMN, UMR 5293, F-33000 Bordeaux, France
2CNRS, IMN, UMR 5293, F-33000 Bordeaux, France
3CEA, GIN, IMN, UMR 5293, F-33000 Bordeaux, France
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N Tzourio-Mazoyer
1Univ. Bordeaux, IMN, UMR 5293, F-33000 Bordeaux, France
2CNRS, IMN, UMR 5293, F-33000 Bordeaux, France
3CEA, GIN, IMN, UMR 5293, F-33000 Bordeaux, France
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Abstract

Even if speech perception and production have been revealed to share a common recruitment of both discrete auditory and motor areas, this overlap being also common to reading and listening, no study has investigated the involvement of larger networks in the three tasks yet. So, we first identified the multimodal bilateral brain areas conjointly activated and asymmetrical during listening, production and reading of word-list using fMRI in 144 healthy right-handers (27 years ± 6 years). Such a selection made it possible to unravel 14 regions of the left hemisphere including motor, premotor and inferior parietal cortical areas. On the right, 7 regions were selected, including the posterior Human Voice Area (pHVA). To characterize the network organization within these 21 regions, we then analysed resting-state functional connectivity in 138 of the same participants. It allowed us to segregate a network of executive areas in relation with task completion from a bilateral WORD_CORE network composed of (1) all left areas supporting the action-perception cycle, in which articulatory gestures are the central motor units on which word perception, production, but also reading, would develop and act together according to the motor theory of speech; (2) the right pHVA, acting as a prosodic integrative area, underpinning the intertwining across hemispheres between prosodic (pHVA) and phonemic (left SMG) processing. The present results show that word processing, whatever the language modality involved, is based on a network of plurimodal areas hosting processes specific to each hemisphere and on their cooperation built upon synchronisation at rest.

Footnotes

  • We have added results from intrinsic connectivity, which has allowed us to discuss hROIs activation and asymmetry according to the networks these hROIs belong to. The introduction section has been fully rewritten and more structured; the hypothesis has been rewritten and more clearly explained, and results have been better described. The discussion section has been organized according to networks synchronized at rest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted May 24, 2019.
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Large-Scale plurimodal networks common to listening, production and reading word-lists: an fmri study combining tasks-induced activation and intrinsic connectivity in 144 right-handers
I Hesling, L Labache, M Joliot, N Tzourio-Mazoyer
bioRxiv 382960; doi: https://doi.org/10.1101/382960
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Large-Scale plurimodal networks common to listening, production and reading word-lists: an fmri study combining tasks-induced activation and intrinsic connectivity in 144 right-handers
I Hesling, L Labache, M Joliot, N Tzourio-Mazoyer
bioRxiv 382960; doi: https://doi.org/10.1101/382960

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