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Novel allosteric mechanism of p53 activation by small molecules for targeted anticancer therapy
View ORCID ProfileJoanna Zawacka-Pankau, Vera V. Grinkevich, Mikhail Burmakin, Aparna Vema, Karin Fawkner, Natalia Issaeva, Virginia Andreotti, Eleanor R. Dickinson, Elisabeth Hedström, Clemens Spinnler, Alberto Inga, Lars-Gunnar Larsson, Anders Karlén, Olga Tarasova, Vladimir Poroikov, Sergey Lavrenov, Maria Preobrazhenskaya, Perdita E. Barran, Andrei L. Okorokov, Galina Selivanova
doi: https://doi.org/10.1101/384248
Joanna Zawacka-Pankau
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Solnavägen 9, Stockholm, SE 171 65, Sweden
Vera V. Grinkevich
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Solnavägen 9, Stockholm, SE 171 65, Sweden
Mikhail Burmakin
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Solnavägen 9, Stockholm, SE 171 65, Sweden
Aparna Vema
2Division of Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala University, P.O. Box 574, BMC, S-751 23 Uppsala, Sweden
Karin Fawkner
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Solnavägen 9, Stockholm, SE 171 65, Sweden
10Present address: TLV, Box 225 20, 104 22, Stockholm frame - the author has deceased during the project
Natalia Issaeva
3Department of Otolaryngology, Yale Physicians Building, 800 Howard Ave, 4th Fl, New Haven, CT 06519
Virginia Andreotti
4Unit of Molecular Mutagenesis and DNA repair, National Institute for Cancer Research, IST, L.go R. Benzi X, 16132 Genoa, Italy
Eleanor R. Dickinson
5Manchester Institute of Biotechnology, The School of Chemistry, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK
Elisabeth Hedström
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Solnavägen 9, Stockholm, SE 171 65, Sweden
Clemens Spinnler
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Solnavägen 9, Stockholm, SE 171 65, Sweden
Alberto Inga
6Centre for Integrative Biology, CIBIO, University of Trento, via Sommarive 9, 38123, Trento, Italy
Lars-Gunnar Larsson
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Solnavägen 9, Stockholm, SE 171 65, Sweden
Anders Karlén
2Division of Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala University, P.O. Box 574, BMC, S-751 23 Uppsala, Sweden
Olga Tarasova
7Department for Bioinformatics, Institute of Biomedical Chemistry, 119121, Moscow, Russia
Vladimir Poroikov
7Department for Bioinformatics, Institute of Biomedical Chemistry, 119121, Moscow, Russia
Sergey Lavrenov
8Gause Institute of New Antibiotics, 119021, Moscow, Russia
Maria Preobrazhenskaya
8Gause Institute of New Antibiotics, 119021, Moscow, Russia
Perdita E. Barran
5Manchester Institute of Biotechnology, The School of Chemistry, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK
Andrei L. Okorokov
9Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK
Galina Selivanova
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Solnavägen 9, Stockholm, SE 171 65, Sweden
Posted December 07, 2018.
Novel allosteric mechanism of p53 activation by small molecules for targeted anticancer therapy
Joanna Zawacka-Pankau, Vera V. Grinkevich, Mikhail Burmakin, Aparna Vema, Karin Fawkner, Natalia Issaeva, Virginia Andreotti, Eleanor R. Dickinson, Elisabeth Hedström, Clemens Spinnler, Alberto Inga, Lars-Gunnar Larsson, Anders Karlén, Olga Tarasova, Vladimir Poroikov, Sergey Lavrenov, Maria Preobrazhenskaya, Perdita E. Barran, Andrei L. Okorokov, Galina Selivanova
bioRxiv 384248; doi: https://doi.org/10.1101/384248
Novel allosteric mechanism of p53 activation by small molecules for targeted anticancer therapy
Joanna Zawacka-Pankau, Vera V. Grinkevich, Mikhail Burmakin, Aparna Vema, Karin Fawkner, Natalia Issaeva, Virginia Andreotti, Eleanor R. Dickinson, Elisabeth Hedström, Clemens Spinnler, Alberto Inga, Lars-Gunnar Larsson, Anders Karlén, Olga Tarasova, Vladimir Poroikov, Sergey Lavrenov, Maria Preobrazhenskaya, Perdita E. Barran, Andrei L. Okorokov, Galina Selivanova
bioRxiv 384248; doi: https://doi.org/10.1101/384248
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