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Programmed mutation of liver fluke granulin using CRISPR/Cas9 attenuates virulence of infection-induced hepatobiliary morbidity

Patpicha Arunsan, Wannaporn Ittiprasert, Michael J. Smout, Christina J. Cochran, Victoria H. Mann, Sujittra Chaiyadet, Shannon E. Karinshak, Banchob Sripa, Neil D. Young, Javier Sotillo, Alex Loukas, Paul J. Brindley, Thewarach Laha
doi: https://doi.org/10.1101/386219
Patpicha Arunsan
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, Washington, DC 20037, USA
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Wannaporn Ittiprasert
Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, Washington, DC 20037, USA
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Michael J. Smout
Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD 4878, Australia
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Christina J. Cochran
Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, Washington, DC 20037, USA
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Victoria H. Mann
Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, Washington, DC 20037, USA
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Sujittra Chaiyadet
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
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Shannon E. Karinshak
Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, Washington, DC 20037, USA
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Banchob Sripa
Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
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Neil D. Young
Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010 Australia
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Javier Sotillo
Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD 4878, Australia
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Alex Loukas
Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD 4878, Australia
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Paul J. Brindley
Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, Washington, DC 20037, USA
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Thewarach Laha
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
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Posted August 18, 2018.
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Programmed mutation of liver fluke granulin using CRISPR/Cas9 attenuates virulence of infection-induced hepatobiliary morbidity
Patpicha Arunsan, Wannaporn Ittiprasert, Michael J. Smout, Christina J. Cochran, Victoria H. Mann, Sujittra Chaiyadet, Shannon E. Karinshak, Banchob Sripa, Neil D. Young, Javier Sotillo, Alex Loukas, Paul J. Brindley, Thewarach Laha
bioRxiv 386219; doi: https://doi.org/10.1101/386219
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Programmed mutation of liver fluke granulin using CRISPR/Cas9 attenuates virulence of infection-induced hepatobiliary morbidity
Patpicha Arunsan, Wannaporn Ittiprasert, Michael J. Smout, Christina J. Cochran, Victoria H. Mann, Sujittra Chaiyadet, Shannon E. Karinshak, Banchob Sripa, Neil D. Young, Javier Sotillo, Alex Loukas, Paul J. Brindley, Thewarach Laha
bioRxiv 386219; doi: https://doi.org/10.1101/386219

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