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Infection of the Biomphalaria glabrata vector snail by Schistosoma mansoni parasites drives snail microbiota dysbiosis

Anaïs Portet, Eve Toulza, Ana Lokmer, Camille Huot, David Duval, Richard Galinier, Benjamin Gourbal
doi: https://doi.org/10.1101/386623
Anaïs Portet
1IHPE, Univ. Montpellier, CNRS, Ifremer, Univ. Perpignan Via Domitia, Perpignan France
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Eve Toulza
1IHPE, Univ. Montpellier, CNRS, Ifremer, Univ. Perpignan Via Domitia, Perpignan France
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Ana Lokmer
2Department Coastal Ecology, Wadden Sea Station Sylt, Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research, List/Sylt, Germany.
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Camille Huot
1IHPE, Univ. Montpellier, CNRS, Ifremer, Univ. Perpignan Via Domitia, Perpignan France
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David Duval
1IHPE, Univ. Montpellier, CNRS, Ifremer, Univ. Perpignan Via Domitia, Perpignan France
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Richard Galinier
1IHPE, Univ. Montpellier, CNRS, Ifremer, Univ. Perpignan Via Domitia, Perpignan France
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Benjamin Gourbal
1IHPE, Univ. Montpellier, CNRS, Ifremer, Univ. Perpignan Via Domitia, Perpignan France
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  • For correspondence: benjamin.gourbal@univ-perp.fr
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Summary

Host-associated microbiota cari affect the fitness of its host i η a number of ways, including the modification of host-parasite interactions and thus the outcome of disease. Biomphalaria glabrata is the vector snail of the trematode Schistosoma mansoni, the agent of human schistosomiasis, causing hundreds of thousands of deaths every year. Here, we present the first study of the snail bacterial microbiota in response to Schistosoma infection. To examine the interplay between B. glabrata, S. mansoni and snail microbiota, snails were infected and the microbiota composition was analysed by massive 16S rDNA amplicon sequencing approach. We characterized the Biomphalaria bacterial microbiota at the individual level in both naive and infected snails. Sympatric and allopatric strains of parasites were used for infections and re­infections to analyse the modification or dysbiosis of snail microbiota in different host-parasite co-evolutionary contexts. Concomitantly, using RNAseq data, we investigated the link between bacterial microbiota dysbiosis and snail anti-microbial peptide immune response. This work paves the way for a better understanding of snail/schistosome interaction, and would have critical consequences in terms of snail control strategies for fighting schistosomiasis disease in the field.

Footnotes

  • AP: ap2133{at}cam.ac.uk, ET: eve.toulza{at}univ-perp.fr, AL: Ana.Lokmer{at}awi.de, CH: camillehuot86{at}gmail.com, DD: david.duval{at}univ-perp.fr, RG: richard.galinier{at}univ-perp.fr, BG: benjamin.gourbal{at}univ-perp.fr

  • We have greatly enhanced the analysis of the results and conclusions of the paper have changed.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 04, 2019.
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Infection of the Biomphalaria glabrata vector snail by Schistosoma mansoni parasites drives snail microbiota dysbiosis
Anaïs Portet, Eve Toulza, Ana Lokmer, Camille Huot, David Duval, Richard Galinier, Benjamin Gourbal
bioRxiv 386623; doi: https://doi.org/10.1101/386623
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Infection of the Biomphalaria glabrata vector snail by Schistosoma mansoni parasites drives snail microbiota dysbiosis
Anaïs Portet, Eve Toulza, Ana Lokmer, Camille Huot, David Duval, Richard Galinier, Benjamin Gourbal
bioRxiv 386623; doi: https://doi.org/10.1101/386623

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