Rapid Diagnosis of Lower Respiratory Infection using Nanopore-based Clinical Metagenomics

Themoula Charalampous; Hollian Richardson; Gemma L. Kay; Rossella Baldan; Christopher Jeanes; Duncan Rae; Sara Grundy; Daniel J. Turner; John Wain; Richard M. Leggett; David M. Livermore; Justin O’Grady

doi:10.1101/387548

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Rapid Diagnosis of Lower Respiratory Infection using Nanopore-based Clinical Metagenomics

Themoula Charalampous, Hollian Richardson, Gemma L. Kay, Rossella Baldan, Christopher Jeanes, Duncan Rae, Sara Grundy, Daniel J. Turner, John Wain, Richard M. Leggett, David M. Livermore, Justin O’Grady

doi: https://doi.org/10.1101/387548

Themoula Charalampous

1Bob Champion Research and Educational Building, University of East Anglia, Norwich Research Park, Colney Ln, Norwich, UK, NR4 7UQ.

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Hollian Richardson

1Bob Champion Research and Educational Building, University of East Anglia, Norwich Research Park, Colney Ln, Norwich, UK, NR4 7UQ.

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Gemma L. Kay

1Bob Champion Research and Educational Building, University of East Anglia, Norwich Research Park, Colney Ln, Norwich, UK, NR4 7UQ.

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Rossella Baldan

1Bob Champion Research and Educational Building, University of East Anglia, Norwich Research Park, Colney Ln, Norwich, UK, NR4 7UQ.

2CIDR, King’s College London, St Thomas’ Hospital, Westminster Bridge Road, London, UK, SE1 7EH.

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Christopher Jeanes

3Microbiology Department, Norwich and Norfolk University Hospital, Conley Ln, Norwich, UK, NR4 7GJ

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Duncan Rae

3Microbiology Department, Norwich and Norfolk University Hospital, Conley Ln, Norwich, UK, NR4 7GJ

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Sara Grundy

3Microbiology Department, Norwich and Norfolk University Hospital, Conley Ln, Norwich, UK, NR4 7GJ

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Daniel J. Turner

4Oxford Nanopore Technologies, Gosling Building, Oxford Science Park, Edmund Halley Rd, Oxford, UK, OX4 4DQ

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John Wain

1Bob Champion Research and Educational Building, University of East Anglia, Norwich Research Park, Colney Ln, Norwich, UK, NR4 7UQ.

5Quadram Institute Bioscience, Norwich Research Park, Colney Ln, Norwich, UK, NR4 7UA

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Richard M. Leggett

6Earlham Institute, Norwich Research Park, Conley Ln, Norwich, UK, NR4 7UZ

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David M. Livermore

1Bob Champion Research and Educational Building, University of East Anglia, Norwich Research Park, Colney Ln, Norwich, UK, NR4 7UQ.

7AMRHAI, Public Health England, 61 Colindale Ave, London, NW9 5EQ.

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Justin O’Grady

1Bob Champion Research and Educational Building, University of East Anglia, Norwich Research Park, Colney Ln, Norwich, UK, NR4 7UQ.

5Quadram Institute Bioscience, Norwich Research Park, Colney Ln, Norwich, UK, NR4 7UA

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For correspondence: justin.ogrady@quadram.ac.uk

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Posted August 09, 2018.

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Rapid Diagnosis of Lower Respiratory Infection using Nanopore-based Clinical Metagenomics

bioRxiv 387548; doi: https://doi.org/10.1101/387548

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