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Occurrence of non-western magic in the European brain

Jan Willem Koten, André Schüppen, Vinod Kumar, Guilherme Wood
doi: https://doi.org/10.1101/395285
Jan Willem Koten
1Institute of Psychology, University of Graz, Graz, Austria
2Interdisciplinary Centre of Clinical Research, University Hospital of the RWTH, Aachen, Germany
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  • For correspondence: jan.koten@gmx.de
André Schüppen
2Interdisciplinary Centre of Clinical Research, University Hospital of the RWTH, Aachen, Germany
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Vinod Kumar
3Max Planck Institute for Biological Cybernetics, Tübingen, Germany
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Guilherme Wood
1Institute of Psychology, University of Graz, Graz, Austria
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ABSTRACT

Timecourses that exhibit identical behaviour at distinct measurement occasions are reliable. Voodoo connectivity occurs when connectivity among brain regions exceeds within subject timecourse reliability. Thus, timecourse reliability limits the true detectable connectivity. We reproduced a working memory related connectome consisting of 561 paths obtained from 67 individuals. We tested >100000 fc-MRI pipelines and show that Savitzky Golay (SG) filters maximize true connectivity while conserving cognitively relevant changes of signals. This is noteworthy for approaches that focus on rapidly changing aspects of connectomes. Furthermore, SG filters detect zombie activity. These “resting state oscillations” are not under human control and contaminate working state signals. SPM pipelines exhibit more voodoo connectivity than SG pipelines. With the SPM pipeline, we observed a connectivity of r=0.44 and a poor true connectivity of r=0.23, but with the SG pipeline we observed a connectivity of r=0.59 and a fair true connectivity of r=0.43. The number of paths detected with fair true connectivity (r >0.4) was 4 for the SPM pipeline but 352 for the SG based pipeline. However, superior statistical properties of SG pipelines may not reflect neural reality. Hence, causal external validation of fc-MRI pipelines is crucial. Without such studies, different pipelines produce at best “alternative maps”.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted August 24, 2018.
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Occurrence of non-western magic in the European brain
Jan Willem Koten, André Schüppen, Vinod Kumar, Guilherme Wood
bioRxiv 395285; doi: https://doi.org/10.1101/395285
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Occurrence of non-western magic in the European brain
Jan Willem Koten, André Schüppen, Vinod Kumar, Guilherme Wood
bioRxiv 395285; doi: https://doi.org/10.1101/395285

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