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Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex

View ORCID ProfileNereo Kalebic, Carlotta Gilardi, Mareike Albert, Takashi Namba, Katherine R. Long, Milos Kostic, Barbara Langen, View ORCID ProfileWieland B. Huttner
doi: https://doi.org/10.1101/395830
Nereo Kalebic
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraβe 108, D-01307 Dresden, Germany
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  • ORCID record for Nereo Kalebic
Carlotta Gilardi
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraβe 108, D-01307 Dresden, Germany
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Mareike Albert
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraβe 108, D-01307 Dresden, Germany
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Takashi Namba
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraβe 108, D-01307 Dresden, Germany
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Katherine R. Long
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraβe 108, D-01307 Dresden, Germany
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Milos Kostic
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraβe 108, D-01307 Dresden, Germany
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Barbara Langen
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraβe 108, D-01307 Dresden, Germany
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Wieland B. Huttner
1Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraβe 108, D-01307 Dresden, Germany
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  • ORCID record for Wieland B. Huttner
  • For correspondence: huttner@mpi-cbg.de
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Abstract

The evolutionary increase in size and complexity of the primate neocortex is thought to underlie the higher cognitive abilities of humans. ARHGAP11B is a human-specific gene that, based on its expression pattern in fetal human neocortex and progenitor effects in embryonic mouse neocortex, has been proposed to have a key function in the evolutionary expansion of the neocortex. Here, we study the effects of ARHGAP11B expression in the developing neocortex of the gyrencephalic ferret. In contrast to its effects in mouse, ARHGAP11B markedly increases proliferative basal radial glia, a progenitor cell type thought to be instrumental for neocortical expansion, and results in extension of the neurogenic period and an increase in upper-layer neurons. As a consequence, the postnatal ferret neocortex exhibits an increased neuron density in the upper cortical layers and expands in the radial dimension. Thus, human-specific ARHGAP11B can elicit hallmarks of neocortical expansion in developing ferret neocortex.

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Posted August 20, 2018.
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Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex
Nereo Kalebic, Carlotta Gilardi, Mareike Albert, Takashi Namba, Katherine R. Long, Milos Kostic, Barbara Langen, Wieland B. Huttner
bioRxiv 395830; doi: https://doi.org/10.1101/395830
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Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex
Nereo Kalebic, Carlotta Gilardi, Mareike Albert, Takashi Namba, Katherine R. Long, Milos Kostic, Barbara Langen, Wieland B. Huttner
bioRxiv 395830; doi: https://doi.org/10.1101/395830

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