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Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes
View ORCID ProfileIrene Miguel-Escalada, Silvia Bonàs-Guarch, Inês Cebola, Ponsa-Cobas Joan, Julen Mendieta-Esteban, Delphine M.Y. Rolando, Biola M. Javierre, Goutham Atla, Irene Farabella, Claire C. Morgan, Javier García-Hurtado, Anthony Beucher, Ignasi Morán, Lorenzo Pasquali, Mireia Ramos, Emil V.R. Appel, Allan Linneberg, Anette P. Gjesing, Daniel R. Witte, Oluf Pedersen, Niels Grarup, Philippe Ravassard, David Torrents, Josep Maria Mercader, Lorenzo Piemonti, Thierry Berney, Eelco J.P. Koning de, Julie Kerr-Conte, François Pattou, Iryna O. Fedko, Inga Prokopenko, Torben Hansen, Marc A. Marti-Renom, Peter Fraser, View ORCID ProfileJorge Ferrer
doi: https://doi.org/10.1101/400291
Irene Miguel-Escalada
1Section of Epigenomics and Disease, Department of Medicine, and National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London W12 0NN, UK
2Genomic Programming of Beta-cells Laboratory, Institut d’Investigacions August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
3CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Spain
30These authors contributed equally
Silvia Bonàs-Guarch
1Section of Epigenomics and Disease, Department of Medicine, and National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London W12 0NN, UK
2Genomic Programming of Beta-cells Laboratory, Institut d’Investigacions August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
3CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Spain
30These authors contributed equally
Inês Cebola
1Section of Epigenomics and Disease, Department of Medicine, and National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London W12 0NN, UK
30These authors contributed equally
Ponsa-Cobas Joan
1Section of Epigenomics and Disease, Department of Medicine, and National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London W12 0NN, UK
Julen Mendieta-Esteban
4CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain
5Universitat Pompeu Fabra (UPF), Barcelona, Spain
6Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain
Delphine M.Y. Rolando
3CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Spain
Biola M. Javierre
7Nuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
8Josep Carreras Leukaemia Research Institute, Campus ICO-Germans Trias i Pujol, Ctra de Can Ruti, Camí de les Escoles s/n, Badalona, 08916, Spain
Goutham Atla
1Section of Epigenomics and Disease, Department of Medicine, and National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London W12 0NN, UK
2Genomic Programming of Beta-cells Laboratory, Institut d’Investigacions August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
3CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Spain
Irene Farabella
4CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain
5Universitat Pompeu Fabra (UPF), Barcelona, Spain
6Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain
Claire C. Morgan
1Section of Epigenomics and Disease, Department of Medicine, and National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London W12 0NN, UK
Javier García-Hurtado
2Genomic Programming of Beta-cells Laboratory, Institut d’Investigacions August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
3CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Spain
Anthony Beucher
1Section of Epigenomics and Disease, Department of Medicine, and National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London W12 0NN, UK
Ignasi Morán
1Section of Epigenomics and Disease, Department of Medicine, and National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London W12 0NN, UK
Lorenzo Pasquali
8Josep Carreras Leukaemia Research Institute, Campus ICO-Germans Trias i Pujol, Ctra de Can Ruti, Camí de les Escoles s/n, Badalona, 08916, Spain
9Program of Predictive and Personalized Medicine of Cancer (PMPPC), Endocrine Regulatory Genomics Lab, Germans Trias i Pujol University Hospital and Research Institute, 08916 Badalona, Spain
Mireia Ramos
9Program of Predictive and Personalized Medicine of Cancer (PMPPC), Endocrine Regulatory Genomics Lab, Germans Trias i Pujol University Hospital and Research Institute, 08916 Badalona, Spain
Emil V.R. Appel
10Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Allan Linneberg
11Center for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark
12Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Anette P. Gjesing
10Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Daniel R. Witte
13Department of Public Health, Aarhus University, Aarhus, Denmark
14Danish Diabetes Academy, Odense, Denmark
Oluf Pedersen
10Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Niels Grarup
10Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Philippe Ravassard
15Université Sorbonne, UPMC Univ Paris 06, Inserm, CNRS, Institut du cerveau et de la moelle (ICM) – Hôpital Pitié-Salpêtrière, Boulevard de l’Hôpital, Paris F-75013, France
David Torrents
16ICREA, Pg. Lluís Companys 23, 08010 Barcelona, Spain
17Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology, 08034 Barcelona, Spain
Josep Maria Mercader
17Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology, 08034 Barcelona, Spain
18- Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
19Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Lorenzo Piemonti
20Diabetes Research Institute (SR-DRI), IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
21Vita-Salute San Raffaele University, Milan
Thierry Berney
22Cell Isolation and Transplantation Center, University of Geneva, 1211 Geneva 4, Switzerland
Eelco J.P. Koning de
23Department of Medicine, Leiden University Medical Center, Box 9600, 2300 RC Leiden, Netherlands
24Hubrecht Institute/KNAW, 85164 3508 AD Utrecht, the Netherlands
Julie Kerr-Conte
25European Genomic Institute for Diabetes, Inserm UMR 1190, Lille 59800, France
François Pattou
25European Genomic Institute for Diabetes, Inserm UMR 1190, Lille 59800, France
Iryna O. Fedko
26Department of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands
27Amsterdam Public Health research institute, The Netherlands
Inga Prokopenko
28Section of Genomics of Common Disease, Department of Medicine, Imperial College London, London W12 0NN, UK
Torben Hansen
10Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Marc A. Marti-Renom
4CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain
5Universitat Pompeu Fabra (UPF), Barcelona, Spain
6Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain
19Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Peter Fraser
7Nuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
29Department of Biological Science, Florida State UniversityThese authors contributed equally, Tallahassee, Florida 32303, USA
Jorge Ferrer
1Section of Epigenomics and Disease, Department of Medicine, and National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London W12 0NN, UK
2Genomic Programming of Beta-cells Laboratory, Institut d’Investigacions August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
3CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Spain
Article usage
Posted August 27, 2018.
Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes
Irene Miguel-Escalada, Silvia Bonàs-Guarch, Inês Cebola, Ponsa-Cobas Joan, Julen Mendieta-Esteban, Delphine M.Y. Rolando, Biola M. Javierre, Goutham Atla, Irene Farabella, Claire C. Morgan, Javier García-Hurtado, Anthony Beucher, Ignasi Morán, Lorenzo Pasquali, Mireia Ramos, Emil V.R. Appel, Allan Linneberg, Anette P. Gjesing, Daniel R. Witte, Oluf Pedersen, Niels Grarup, Philippe Ravassard, David Torrents, Josep Maria Mercader, Lorenzo Piemonti, Thierry Berney, Eelco J.P. Koning de, Julie Kerr-Conte, François Pattou, Iryna O. Fedko, Inga Prokopenko, Torben Hansen, Marc A. Marti-Renom, Peter Fraser, Jorge Ferrer
bioRxiv 400291; doi: https://doi.org/10.1101/400291
Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes
Irene Miguel-Escalada, Silvia Bonàs-Guarch, Inês Cebola, Ponsa-Cobas Joan, Julen Mendieta-Esteban, Delphine M.Y. Rolando, Biola M. Javierre, Goutham Atla, Irene Farabella, Claire C. Morgan, Javier García-Hurtado, Anthony Beucher, Ignasi Morán, Lorenzo Pasquali, Mireia Ramos, Emil V.R. Appel, Allan Linneberg, Anette P. Gjesing, Daniel R. Witte, Oluf Pedersen, Niels Grarup, Philippe Ravassard, David Torrents, Josep Maria Mercader, Lorenzo Piemonti, Thierry Berney, Eelco J.P. Koning de, Julie Kerr-Conte, François Pattou, Iryna O. Fedko, Inga Prokopenko, Torben Hansen, Marc A. Marti-Renom, Peter Fraser, Jorge Ferrer
bioRxiv 400291; doi: https://doi.org/10.1101/400291
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