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Modulation of the spontaneous hemodynamic response function across levels of consciousness

Guo-Rong Wu, Carol Di Perri, Vanessa Charland-Verville, Charlotte Martial, Steven Laureys, Daniele Marinazzo
doi: https://doi.org/10.1101/401547
Guo-Rong Wu
1Department of Data Analysis, University of Ghent, B9000 Ghent, Belgium
2Key Laboratory of Cognition and Personality, Faculty of Psychology, Southwest University, Chongqing 400715, China
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Carol Di Perri
3Coma Science Group, GIGA Research Center, University of Liège, B4000 Liège, Belgium
4Center for Clinical Brain Sciences, Centre for Dementia Prevention, UK Dementia Research Institute, University of Edinburgh, EH16 4SB Edinburgh, United Kingdom
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Vanessa Charland-Verville
3Coma Science Group, GIGA Research Center, University of Liège, B4000 Liège, Belgium
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Charlotte Martial
3Coma Science Group, GIGA Research Center, University of Liège, B4000 Liège, Belgium
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Steven Laureys
3Coma Science Group, GIGA Research Center, University of Liège, B4000 Liège, Belgium
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Daniele Marinazzo
1Department of Data Analysis, University of Ghent, B9000 Ghent, Belgium
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Abstract

Functional imaging research has already contributed with several results to the study of neural correlates of consciousness. Apart from task-related activation derived in fMRI, PET based glucose metabolism rate or cerebral blood flow account for a considerable proportion of the study of brain activity under different levels of consciousness. Resting state functional connectivity MRI is playing a crucial role to explore the consciousness related functional integration, successfully complementing PET, another widely used neuroimaging technique. Here, spontaneous hemodynamic response is introduced to characterize resting state brain activity giving information on the local metabolism (neurovascular coupling), and useful to improve the time-resolved activity and connectivity measures based on BOLD fMRI. This voxel-wise measure is then used to investigate the loss of consciousness under Propofol anesthesia and unresponsive wakefulness syndrome. The dysfunction of hemodynamic response in precuneus and posterior cingulate is found to be a common principle underlying loss of consciousness in both conditions. The thalamus appears to be less obviously modulated by Propofol, compared with frontoparietal regions. However, a significant increase in spontaneous thalamic hemodynamic response was found in patients in unresponsive wakefulness syndrome compared with healthy control. Our results ultimately show that anesthesia- or pathology-induced neurovascular coupling could be tracked by modulated spontaneous hemodynamic response derived from resting state fMRI.

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  • ↵* Joint last authors

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted August 27, 2018.
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Modulation of the spontaneous hemodynamic response function across levels of consciousness
Guo-Rong Wu, Carol Di Perri, Vanessa Charland-Verville, Charlotte Martial, Steven Laureys, Daniele Marinazzo
bioRxiv 401547; doi: https://doi.org/10.1101/401547
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Modulation of the spontaneous hemodynamic response function across levels of consciousness
Guo-Rong Wu, Carol Di Perri, Vanessa Charland-Verville, Charlotte Martial, Steven Laureys, Daniele Marinazzo
bioRxiv 401547; doi: https://doi.org/10.1101/401547

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