Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Neural basis of Transcranial Magnetic Stimulation at the single-cell Level

Maria C. Romero, Marco Davare, Marcelo Armendariz, Peter Janssen
doi: https://doi.org/10.1101/405753
Maria C. Romero
1Lab. voor Neuro- en Psychofysiologie, KU Leuven, Leuven, Belgium
2Onderzoeksgroep Bewegingscontrole & Neuroplasticiteit, KU Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marco Davare
2Onderzoeksgroep Bewegingscontrole & Neuroplasticiteit, KU Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marcelo Armendariz
1Lab. voor Neuro- en Psychofysiologie, KU Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter Janssen
1Lab. voor Neuro- en Psychofysiologie, KU Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Transcranial Magnetic Stimulation (TMS) can non-invasively modulate neural activity in humans. Despite three decades of research, the spatial extent of the cortical area activated by TMS is still controversial. Moreover, how TMS interacts with task-related activity during motor behavior is unknown. We applied single-pulse TMS over the macaque parietal cortex while recording single-unit activity at various distances from the center of stimulation during grasping. The spatial extent of the TMS-induced activation was remarkably restricted, affecting single neurons in a volume of cortex measuring less than 2 mm. In task-related neurons, TMS evoked a transient excitation followed by reduced activity, which was paralleled by a significantly longer grasping time. Furthermore, TMS- induced activity and task-related activity did not summate in single neurons. These results furnish crucial experimental evidence for the neural basis of the TMS effect at the single-cell level and uncover, the neural underpinnings of behavioral effects of TMS.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted August 31, 2018.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Neural basis of Transcranial Magnetic Stimulation at the single-cell Level
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Neural basis of Transcranial Magnetic Stimulation at the single-cell Level
Maria C. Romero, Marco Davare, Marcelo Armendariz, Peter Janssen
bioRxiv 405753; doi: https://doi.org/10.1101/405753
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Neural basis of Transcranial Magnetic Stimulation at the single-cell Level
Maria C. Romero, Marco Davare, Marcelo Armendariz, Peter Janssen
bioRxiv 405753; doi: https://doi.org/10.1101/405753

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4095)
  • Biochemistry (8788)
  • Bioengineering (6493)
  • Bioinformatics (23396)
  • Biophysics (11766)
  • Cancer Biology (9171)
  • Cell Biology (13292)
  • Clinical Trials (138)
  • Developmental Biology (7423)
  • Ecology (11389)
  • Epidemiology (2066)
  • Evolutionary Biology (15121)
  • Genetics (10415)
  • Genomics (14026)
  • Immunology (9152)
  • Microbiology (22111)
  • Molecular Biology (8793)
  • Neuroscience (47460)
  • Paleontology (350)
  • Pathology (1423)
  • Pharmacology and Toxicology (2486)
  • Physiology (3712)
  • Plant Biology (8069)
  • Scientific Communication and Education (1433)
  • Synthetic Biology (2216)
  • Systems Biology (6022)
  • Zoology (1251)