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Mutant screen for reproduction unveils depression-associated Piccolo’s control over reproductive behavior

Gerardo A. Medrano, View ORCID ProfileManvendra Singh, Erik J. Plautz, Levi B. Good, Karen M. Chapman, Jaideep Chaudhary, Priscilla Jaichander, Heather M. Powell, Ashutosh Pudasaini, John M. Shelton, James A. Richardson, Xian-Jin Xie, Zoltán Ivics, Christine Braun, Frauke Ackermann, Craig C. Garner, Zsuzsanna Izsvák, F. Kent Hamra
doi: https://doi.org/10.1101/405985
Gerardo A. Medrano
1Department of Pharmacology, University of Texas Southwestern Medical Center in Dallas, USA
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Manvendra Singh
11Max Delbrück Center for Molecular Medicine in the Helmholtz Society, Berlin, Germany
12Department of Molecular Biology & Genetics, 526 Campus Road, Cornell University, Ithaca, NY 14853
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  • ORCID record for Manvendra Singh
Erik J. Plautz
6Division of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center in Dallas, USA
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Levi B. Good
6Division of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center in Dallas, USA
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Karen M. Chapman
1Department of Pharmacology, University of Texas Southwestern Medical Center in Dallas, USA
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Jaideep Chaudhary
1Department of Pharmacology, University of Texas Southwestern Medical Center in Dallas, USA
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Priscilla Jaichander
1Department of Pharmacology, University of Texas Southwestern Medical Center in Dallas, USA
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Heather M. Powell
1Department of Pharmacology, University of Texas Southwestern Medical Center in Dallas, USA
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Ashutosh Pudasaini
2Department of Obstetrics & Gynecology, Internal Medicine, University of Texas Southwestern Medical Center in Dallas, USA
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John M. Shelton
3Division of Cardiology, University of Texas Southwestern Medical Center in Dallas, USA
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James A. Richardson
4Division of Pathology, University of Texas Southwestern Medical Center in Dallas, USA
5Division of Molecular Biology, University of Texas Southwestern Medical Center in Dallas, USA
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Xian-Jin Xie
7Division of Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center in Dallas, USA
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Zoltán Ivics
9Paul-Ehrlich-Institute, Division of Medical Biotechnology, Langen, Germany, German Center for Neurodegenerative Diseases (DZNE)
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Christine Braun
10Charité Medical University, Charitéplatz, Berlin, Germany
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Frauke Ackermann
10Charité Medical University, Charitéplatz, Berlin, Germany
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Craig C. Garner
10Charité Medical University, Charitéplatz, Berlin, Germany
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Zsuzsanna Izsvák
11Max Delbrück Center for Molecular Medicine in the Helmholtz Society, Berlin, Germany
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  • For correspondence: kent.hamra@utsouthwestern.edu
F. Kent Hamra
1Department of Pharmacology, University of Texas Southwestern Medical Center in Dallas, USA
2Department of Obstetrics & Gynecology, Internal Medicine, University of Texas Southwestern Medical Center in Dallas, USA
8Division of Cecil H & Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center in Dallas, USA
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  • For correspondence: kent.hamra@utsouthwestern.edu
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Article Information

doi 
https://doi.org/10.1101/405985
History 
  • March 19, 2020.

Article Versions

  • Version 1 (August 31, 2018 - 13:40).
  • Version 2 (May 14, 2019 - 09:55).
  • You are viewing Version 3, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Gerardo A. Medrano1,&,
  2. Manvendra Singh11,12,&,
  3. Erik J. Plautz6,
  4. Levi B. Good6,
  5. Karen M. Chapman1,
  6. Jaideep Chaudhary1,
  7. Priscilla Jaichander1,
  8. Heather M. Powell1,
  9. Ashutosh Pudasaini2,
  10. John M. Shelton3,
  11. James A. Richardson4,5,
  12. Xian-Jin Xie7,
  13. Zoltán Ivics9,
  14. Christine Braun10,
  15. Frauke Ackermann10,
  16. Craig C. Garner10,
  17. Zsuzsanna Izsvák11,* and
  18. F. Kent Hamra1,2,8,*
  1. 1Department of Pharmacology, University of Texas Southwestern Medical Center in Dallas, USA
  2. 2Department of Obstetrics & Gynecology, Internal Medicine, University of Texas Southwestern Medical Center in Dallas, USA
  3. 3Division of Cardiology, University of Texas Southwestern Medical Center in Dallas, USA
  4. 4Division of Pathology, University of Texas Southwestern Medical Center in Dallas, USA
  5. 5Division of Molecular Biology, University of Texas Southwestern Medical Center in Dallas, USA
  6. 6Division of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center in Dallas, USA
  7. 7Division of Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center in Dallas, USA
  8. 8Division of Cecil H & Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center in Dallas, USA
  9. 9Paul-Ehrlich-Institute, Division of Medical Biotechnology, Langen, Germany, German Center for Neurodegenerative Diseases (DZNE)
  10. 10Charité Medical University, Charitéplatz, Berlin, Germany
  11. 11Max Delbrück Center for Molecular Medicine in the Helmholtz Society, Berlin, Germany
  12. 12Department of Molecular Biology & Genetics, 526 Campus Road, Cornell University, Ithaca, NY 14853
  1. ↵*Correspondence: F. Kent Hamra kent.hamra{at}utsouthwestern.edu (Sperm stem cell lines/Rat models) and Zsuzsanna Izsvák www.mdc-berlin.de/izsvak (Transposon Mutagenesis)
  1. ↵& Equal contributions

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Mutant screen for reproduction unveils depression-associated Piccolo’s control over reproductive behavior
Gerardo A. Medrano, Manvendra Singh, Erik J. Plautz, Levi B. Good, Karen M. Chapman, Jaideep Chaudhary, Priscilla Jaichander, Heather M. Powell, Ashutosh Pudasaini, John M. Shelton, James A. Richardson, Xian-Jin Xie, Zoltán Ivics, Christine Braun, Frauke Ackermann, Craig C. Garner, Zsuzsanna Izsvák, F. Kent Hamra
bioRxiv 405985; doi: https://doi.org/10.1101/405985
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Mutant screen for reproduction unveils depression-associated Piccolo’s control over reproductive behavior
Gerardo A. Medrano, Manvendra Singh, Erik J. Plautz, Levi B. Good, Karen M. Chapman, Jaideep Chaudhary, Priscilla Jaichander, Heather M. Powell, Ashutosh Pudasaini, John M. Shelton, James A. Richardson, Xian-Jin Xie, Zoltán Ivics, Christine Braun, Frauke Ackermann, Craig C. Garner, Zsuzsanna Izsvák, F. Kent Hamra
bioRxiv 405985; doi: https://doi.org/10.1101/405985

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