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Harnessing Avidity: Quantifying Entropic and Energetic Effects of Linker Length and Rigidity Required for Multivalent Binding of Antibodies to HIV-1 Spikes
View ORCID ProfileTal Einav, Shahrzad Yazdi, Aaron Coey, View ORCID ProfilePamela J. Bjorkman, View ORCID ProfileRob Phillips
doi: https://doi.org/10.1101/406454
Tal Einav
aDepartment of Physics, California Institute of Technology, Pasadena, CA 91125
Shahrzad Yazdi
bDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139
Aaron Coey
cDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125
Pamela J. Bjorkman
cDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125
Rob Phillips
aDepartment of Physics, California Institute of Technology, Pasadena, CA 91125
cDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125
dDepartment of Applied Physics, California Institute of Technology, Pasadena, CA 91125
Posted May 22, 2019.
Harnessing Avidity: Quantifying Entropic and Energetic Effects of Linker Length and Rigidity Required for Multivalent Binding of Antibodies to HIV-1 Spikes
Tal Einav, Shahrzad Yazdi, Aaron Coey, Pamela J. Bjorkman, Rob Phillips
bioRxiv 406454; doi: https://doi.org/10.1101/406454
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