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Spectral Contrast Optical Coherence Tomography Angiography Enables Single-Scan Vessel Imaging

James A. Winkelmann, Graham Spicer, Aya Eid, Luay M. Almassalha, The-Quyen Nyguen, Vadim Backman
doi: https://doi.org/10.1101/406652
James A. Winkelmann
1Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
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Graham Spicer
2Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, USA
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Aya Eid
1Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
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Luay M. Almassalha
1Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
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The-Quyen Nyguen
1Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
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Vadim Backman
1Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA
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Abstract

Optical Coherence Tomography angiography relies on motion for contrast and requires at least two data acquisitions per point-wise scanning location. We present a method termed Spectral Contrast Optical Coherence Tomography Angiography using visible light which relies on the spectral signatures of blood to obtain angiography from a single scan using endogenous contrast. We demonstrate the molecular sensitivity of this method enabling lymphatic, blood, and tissue discrimination.

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Posted September 16, 2018.
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Spectral Contrast Optical Coherence Tomography Angiography Enables Single-Scan Vessel Imaging
James A. Winkelmann, Graham Spicer, Aya Eid, Luay M. Almassalha, The-Quyen Nyguen, Vadim Backman
bioRxiv 406652; doi: https://doi.org/10.1101/406652
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Spectral Contrast Optical Coherence Tomography Angiography Enables Single-Scan Vessel Imaging
James A. Winkelmann, Graham Spicer, Aya Eid, Luay M. Almassalha, The-Quyen Nyguen, Vadim Backman
bioRxiv 406652; doi: https://doi.org/10.1101/406652

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