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On the interpretation of tractography-based parcellations

View ORCID ProfileJonathan D. Clayden, David L. Thomas, Alexander Kraskov
doi: https://doi.org/10.1101/409268
Jonathan D. Clayden
1Developmental Imaging and Biophysics Section, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom
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  • For correspondence: j.clayden@ucl.ac.uk
David L. Thomas
2Neuroradiological Academic Unit, UCL Institute of Neurology, University College London, London, United Kingdom
3Leonard Wolfson Experimental Neurology Centre, UCL Institute of Neurology, Queen Square, London, United Kingdom
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Alexander Kraskov
4Department of Clinical and Movement Neurosciences, UCL Institute of Neurology, University College London, London, United Kingdom
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Abstract

Connectivity-based parcellation of subcortical structures using diffusion tractography is now a common paradigm in neuroscience. These analyses often imply voxel-level specificity of connectivity, and the formation of compact, spatially coherent clusters is often taken as strong imaging-based evidence for anatomically distinct subnuclei in an individual. In this study, we demonstrate that internal structure in diffusion anisotropy is not necessary for a plausible parcellation to be obtained, by spatially permuting diffusion parameters within the thalami and repeating the parcellation. Moreover, we show that, in a winner-takes-all paradigm, most voxels receive the same label before and after this shuffling process—a finding that is stable across image acquisitions and tractography algorithms. We therefore suggest that such parcellations should be interpreted with caution.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted September 06, 2018.
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On the interpretation of tractography-based parcellations
Jonathan D. Clayden, David L. Thomas, Alexander Kraskov
bioRxiv 409268; doi: https://doi.org/10.1101/409268
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On the interpretation of tractography-based parcellations
Jonathan D. Clayden, David L. Thomas, Alexander Kraskov
bioRxiv 409268; doi: https://doi.org/10.1101/409268

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