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The direct costs of overdiagnosed asthma in a longitudinal population-based study

View ORCID ProfileBryan C. Ng, Mohsen Sadatsafavi, Abdollah Safari, J. Mark FitzGerald, Kate M. Johnson
doi: https://doi.org/10.1101/409870
Bryan C. Ng
1Respiratory Evaluation Sciences Program, Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
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  • ORCID record for Bryan C. Ng
Mohsen Sadatsafavi
1Respiratory Evaluation Sciences Program, Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
2Institute for Heart and Lung Health, Department of Medicine, University of British Columbia, Vancouver, Canada
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Abdollah Safari
1Respiratory Evaluation Sciences Program, Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
2Institute for Heart and Lung Health, Department of Medicine, University of British Columbia, Vancouver, Canada
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J. Mark FitzGerald
2Institute for Heart and Lung Health, Department of Medicine, University of British Columbia, Vancouver, Canada
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Kate M. Johnson
1Respiratory Evaluation Sciences Program, Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
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  • For correspondence: kate.johnson@alumni.ubc.ca
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ABSTRACT

Objectives A current diagnosis of asthma cannot be objectively confirmed in many patients with physician-diagnosed asthma. Estimates of resource use in overdiagnosed cases of asthma are necessary to measure the burden of overdiagnosis and evaluate strategies to reduce this burden. We assessed the difference in asthma-related healthcare resource use between patients with a confirmed asthma diagnosis and those with asthma ruled out.

Design Population-based prospective cohort study.

Setting Participants were recruited through random-digit dialling of both landlines and mobile phones in BC, Canada.

Participants We included 345 individuals ≥12 years of age with a self-reported physician diagnosis of asthma which was confirmed by a bronchodilator reversibility or methacholine challenge test at the end of the 12-month follow-up.

Primary and secondary outcome measures Self-reported annual asthma-related direct healthcare costs (2017 Canadian dollars), outpatient physician visits, and medication use from the Canadian healthcare system perspective.

Results Asthma was ruled out in 86 (24.9%) participants. Average annual asthma-related direct healthcare costs for participants with confirmed asthma were $497.9 (SD $677.9), and $307.7 (SD $424.1) for participants with asthma ruled out. In the adjusted analyses, a confirmed diagnosis was associated with higher direct healthcare costs (Relative Ratio [RR]=1.60, 95%CI 1.14-2.22), increased rate of specialist visits (RR=2.41, 95%CI 1.05-5.40) and reliever medication use (RR=1.62, 95%CI 1.09-2.35), but not primary care physician visits (p=0.10) or controller medication use (p=0.11).

Conclusions A quarter of individuals with a physician diagnosis of asthma did not have asthma after objective re-evaluation. These participants still consumed a significant amount of asthma-related healthcare resources. The population-level economic burden of asthma overdiagnosis could be substantial.

Strengths and limitations of this study

  • Participants were recruited through random sampling of the general population in the province of British Columbia.

  • Asthma diagnosis was confirmed or ruled out using sequential guideline-recommended objective airway tests.

  • Healthcare resource use was self-reported, potential recall bias may have led to reduced accuracy.

  • The study was unable to evaluate the indirect costs of overdiagnosis or the cost-savings from correcting the diagnosis.

  • The generalizability of the results may be limited by regional differences in medical costs and practices.

Footnotes

  • Minor revisions to title, abstract, and manuscript introduction/methods/results/discussion/conclusion sections. Table 2 added to clarify results. Author affiliations updated.

  • ABBREVIATIONS

    BC
    British Columbia
    CI
    Confidence Interval
    FEV1
    Forced Expiratory Volume in 1 second
    MPR
    Medication Possession Ratio
    SD
    Standard Deviation
  • Copyright 
    The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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    Posted July 03, 2019.
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    The direct costs of overdiagnosed asthma in a longitudinal population-based study
    Bryan C. Ng, Mohsen Sadatsafavi, Abdollah Safari, J. Mark FitzGerald, Kate M. Johnson
    bioRxiv 409870; doi: https://doi.org/10.1101/409870
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    The direct costs of overdiagnosed asthma in a longitudinal population-based study
    Bryan C. Ng, Mohsen Sadatsafavi, Abdollah Safari, J. Mark FitzGerald, Kate M. Johnson
    bioRxiv 409870; doi: https://doi.org/10.1101/409870

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