Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Dynamic 3D tissue architecture directs BMP morphogen signaling during Drosophila wing morphogenesis

Jinghua Gui, Yunxian Huang, Martin Kracklauer, Daniel Toddie-Moore, Kenji Kikushima, Stephanie Nix, Yukitaka Ishimoto, Osamu Shimmi
doi: https://doi.org/10.1101/411009
Jinghua Gui
University of Helsinki;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yunxian Huang
University of Helsinki;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martin Kracklauer
University of Helsinki;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel Toddie-Moore
University of Helsinki;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kenji Kikushima
University of Helsinki;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stephanie Nix
Akita Prefectural University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yukitaka Ishimoto
Akita Prefectural University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Osamu Shimmi
University of Helsinki;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: shimm3036@gmail.com
  • Abstract
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

At the level of organ formation, tissue morphogenesis drives developmental processes in animals, often involving the rearrangement of two-dimensional (2D) structures into more complex three-dimensional (3D) tissues. These processes can be directed by growth factor signaling pathways. However, little is known about how such morphological changes affect the spatiotemporal distribution of growth factor signaling. Here, using the Drosophila pupal wing, we address how Decapentaplegic (Dpp) / Bone Morphogenetic Protein (BMP) signaling and 3D wing morphogenesis are coupled. Dpp, expressed in the longitudinal veins (LVs) of the pupal wing, initially diffuses laterally during the inflation stage to regulate cell proliferation. Dpp localization is then refined to the LVs within each epithelial plane, but with active interplanar signaling for vein patterning, as the two epithelia appose. Our data further suggest that the 3D architecture of the wing epithelia directs the spatial distribution of BMP signaling, revealing how 3D morphogenesis is an emergent property of the interactions between extracellular signaling and tissue shape changes.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted September 06, 2018.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Dynamic 3D tissue architecture directs BMP morphogen signaling during Drosophila wing morphogenesis
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
Dynamic 3D tissue architecture directs BMP morphogen signaling during Drosophila wing morphogenesis
Jinghua Gui, Yunxian Huang, Martin Kracklauer, Daniel Toddie-Moore, Kenji Kikushima, Stephanie Nix, Yukitaka Ishimoto, Osamu Shimmi
bioRxiv 411009; doi: https://doi.org/10.1101/411009
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Dynamic 3D tissue architecture directs BMP morphogen signaling during Drosophila wing morphogenesis
Jinghua Gui, Yunxian Huang, Martin Kracklauer, Daniel Toddie-Moore, Kenji Kikushima, Stephanie Nix, Yukitaka Ishimoto, Osamu Shimmi
bioRxiv 411009; doi: https://doi.org/10.1101/411009

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Developmental Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (998)
  • Biochemistry (1490)
  • Bioengineering (944)
  • Bioinformatics (6829)
  • Biophysics (2422)
  • Cancer Biology (1787)
  • Cell Biology (2529)
  • Clinical Trials (106)
  • Developmental Biology (1698)
  • Ecology (2568)
  • Epidemiology (1494)
  • Evolutionary Biology (5026)
  • Genetics (3617)
  • Genomics (4627)
  • Immunology (1169)
  • Microbiology (4250)
  • Molecular Biology (1623)
  • Neuroscience (10792)
  • Paleontology (82)
  • Pathology (239)
  • Pharmacology and Toxicology (409)
  • Physiology (555)
  • Plant Biology (1456)
  • Scientific Communication and Education (412)
  • Synthetic Biology (542)
  • Systems Biology (1873)
  • Zoology (260)