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The emergence of dynamical instantaneous memory in the spontaneous activity of spatially confined neuronal assemblies in vitro

Y. Piasetzky, M. Bisio, S. Kanner, M Goldin, M. Olivenbaum, E. Ben-Jacob, Y Hanein, M. Chiappalone, A. Barzilai, P. Bonifazi
doi: https://doi.org/10.1101/412320
Y. Piasetzky
1School of Physics and Astronomy, Tel Aviv University Ramat Aviv, 69978 Israel.
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M. Bisio
2Department of Neuroscience, University of Padova, Via Giustiniani 2 - 35128, Padova, Italy.
3Padova Neuroscience Center (PNC), University of Padova Italy.
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S. Kanner
4Department of Neurobiology, George S. Wise, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
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M Goldin
1School of Physics and Astronomy, Tel Aviv University Ramat Aviv, 69978 Israel.
5Computational Neuroimaging Laboratory, Biocruces Health Research Institute, Hospital Universitario Cruces, 48903 Baracaldo, Vizcaya, Spain.
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M. Olivenbaum
1School of Physics and Astronomy, Tel Aviv University Ramat Aviv, 69978 Israel.
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E. Ben-Jacob
1School of Physics and Astronomy, Tel Aviv University Ramat Aviv, 69978 Israel.
6Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel.
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Y Hanein
6Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel.
7School of Electrical Engineering, Tel Aviv University, Tel Aviv 69978, Israel.
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M. Chiappalone
8Rehab Technologies, Istituto Italiano di Tecnologia, Via Morego 30, Genova, Italy.
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A. Barzilai
4Department of Neurobiology, George S. Wise, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
6Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel.
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P. Bonifazi
1School of Physics and Astronomy, Tel Aviv University Ramat Aviv, 69978 Israel.
5Computational Neuroimaging Laboratory, Biocruces Health Research Institute, Hospital Universitario Cruces, 48903 Baracaldo, Vizcaya, Spain.
9Ikerbasque: The Basque Foundation for Science, Bilbao, Spain.
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Abstract

Understanding the dynamics between communicating cell assemblies is essential for deciphering the neural code and identifying the mechanism underlying memory formation. In this work, in order to unveil possible emergent intrinsic memory phenomena in the communication between cell assemblies, we study the spontaneous dynamics of in vitro spatially confined inter-connected neuronal circuits grown on multi-electrode arrays. The spontaneous dynamics of the global network was characterized by the coupling of the activity independently generated by each circuit. The asymptotic functional connectivity of the network reflected its modular organization. Instantaneous functional connectivity maps on ten seconds epochs, revealed more complex dynamical states with the simultaneous activation of distinct circuits. When looking at the similarity of the generated network events, we observed that spontaneous network events occurring at temporal distances below two dozens of seconds had an average higher similarity compared to randomly played network events. Such a memory phenomenon was not observed in networks where spontaneous events were less frequent and in networks topologically organized as open lines. These results support the hypothesis that dynamical instantaneous memory, characterized by drifting network dynamics with decaying degree of similarity, is an intrinsic property of neuronal networks.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 10, 2018.
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The emergence of dynamical instantaneous memory in the spontaneous activity of spatially confined neuronal assemblies in vitro
Y. Piasetzky, M. Bisio, S. Kanner, M Goldin, M. Olivenbaum, E. Ben-Jacob, Y Hanein, M. Chiappalone, A. Barzilai, P. Bonifazi
bioRxiv 412320; doi: https://doi.org/10.1101/412320
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The emergence of dynamical instantaneous memory in the spontaneous activity of spatially confined neuronal assemblies in vitro
Y. Piasetzky, M. Bisio, S. Kanner, M Goldin, M. Olivenbaum, E. Ben-Jacob, Y Hanein, M. Chiappalone, A. Barzilai, P. Bonifazi
bioRxiv 412320; doi: https://doi.org/10.1101/412320

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