Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Macaque dorsal premotor cortex exhibits decision-related activity only when specific stimulus-response associations are known

Megan Wang, Christéva Montanède, View ORCID ProfileChandramouli Chandrasekaran, View ORCID ProfileDiogo Peixoto, View ORCID ProfileKrishna V. Shenoy, John F. Kalaska
doi: https://doi.org/10.1101/412528
Megan Wang
Neurosciences Graduate Program, Stanford University, Stanford, CA 94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: mwang4@stanford.edu john.francis.kalaska@umontreal.ca
Christéva Montanède
Département de Neurosciences, Pavillon Paul-G.-Desmarais, Faculté de Médecine, Université de Montréal, succursale Centre-ville, Montréal, Québec, H3C 3J7, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chandramouli Chandrasekaran
Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USAHoward Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Chandramouli Chandrasekaran
Diogo Peixoto
Department of Neurobiology, Stanford University, Stanford, CA 94305, USAChampalimaud Neuroscience Programme, Lisbon 1400-038, Portugal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Diogo Peixoto
Krishna V. Shenoy
Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USADepartment of Neurobiology, Stanford University, Stanford, CA 94305, USADepartment of Bioengineering, Stanford University, Stanford, CA 94305, USABio-X Program Stanford University, Stanford, CA 94305, USAStanford Neurosciences Institute, Stanford University, Stanford, CA 94305, USAHoward Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Krishna V. Shenoy
John F. Kalaska
Département de Neurosciences, Pavillon Paul-G.-Desmarais, Faculté de Médecine, Université de Montréal, succursale Centre-ville, Montréal, Québec, H3C 3J7, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: mwang4@stanford.edu john.francis.kalaska@umontreal.ca
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Summary

How deliberation on sensory cues and action selection interact in decision-related brain areas is still not well understood. Here, monkeys reached to one of two targets, whose colors alternated randomly between trials, by discriminating the dominant color of a checkerboard cue composed of different numbers of squares of the two target colors in different trials. In a “Targets First” task the colored targets appeared first, followed by the checkerboard; in a “Checkerboard First” task, this order was reversed. After both cues appeared in both tasks, responses of dorsal premotor cortex (PMd) neurons covaried with action choices, strength of evidence for action choices, and RTs--- hallmarks of decision-related activity. However, very few neurons were modulated by checkerboard color composition or the color of the chosen target, even in the Checkerboard First task. These findings implicate PMd in the action-selection but not the perceptual components of the decision-making process in these tasks.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted September 09, 2018.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Macaque dorsal premotor cortex exhibits decision-related activity only when specific stimulus-response associations are known
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
Share
Macaque dorsal premotor cortex exhibits decision-related activity only when specific stimulus-response associations are known
Megan Wang, Christéva Montanède, Chandramouli Chandrasekaran, Diogo Peixoto, Krishna V. Shenoy, John F. Kalaska
bioRxiv 412528; doi: https://doi.org/10.1101/412528
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Macaque dorsal premotor cortex exhibits decision-related activity only when specific stimulus-response associations are known
Megan Wang, Christéva Montanède, Chandramouli Chandrasekaran, Diogo Peixoto, Krishna V. Shenoy, John F. Kalaska
bioRxiv 412528; doi: https://doi.org/10.1101/412528

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (1647)
  • Biochemistry (2739)
  • Bioengineering (1907)
  • Bioinformatics (10243)
  • Biophysics (4183)
  • Cancer Biology (3218)
  • Cell Biology (4539)
  • Clinical Trials (135)
  • Developmental Biology (2840)
  • Ecology (4461)
  • Epidemiology (2041)
  • Evolutionary Biology (7231)
  • Genetics (5477)
  • Genomics (6813)
  • Immunology (2390)
  • Microbiology (7485)
  • Molecular Biology (2993)
  • Neuroscience (18584)
  • Paleontology (136)
  • Pathology (472)
  • Pharmacology and Toxicology (780)
  • Physiology (1150)
  • Plant Biology (2706)
  • Scientific Communication and Education (680)
  • Synthetic Biology (888)
  • Systems Biology (2846)
  • Zoology (468)