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Mechanical Coupling Coordinates the Co-elongation of Axial and Paraxial Tissues in Avian Embryos

View ORCID ProfileFengzhu Xiong, Wenzhe Ma, Bertrand Bénazéraf, View ORCID ProfileL. Mahadevan, View ORCID ProfileOlivier Pourquié
doi: https://doi.org/10.1101/412866
Fengzhu Xiong
1Department of Pathology, Brigham Women’s Hospital, Boston, MA 02115, USA
2Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
3Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
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Wenzhe Ma
4Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
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Bertrand Bénazéraf
5Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, France
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L. Mahadevan
3Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
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Olivier Pourquié
1Department of Pathology, Brigham Women’s Hospital, Boston, MA 02115, USA
2Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
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  • For correspondence: pourquie@hms.harvard.edu
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SUMMARY

Tissues undergoing morphogenesis impose mechanical effects on one another. How developmental programs adapt to or take advantage of these effects remains poorly explored. Here, using a combination of live imaging, modeling, and microsurgical perturbations, we show that the axial and paraxial tissues in the forming avian embryonic body coordinate their rates of elongation through mechanical interactions. First, a cell motility gradient drives paraxial presomitic mesoderm (PSM) expansion, resulting in compression of the axial neural tube and notochord; second, elongation of axial tissues driven by PSM compression and polarized cell intercalation pushes the caudal progenitor domain posteriorly; finally, the axial push drives progenitors to emigrate into the PSM to maintain tissue growth and cell motility. These interactions form an engine-like positive feedback loop, which ensures the tissue-coupling and self-sustaining characteristics of body elongation. Our results suggest a general role of inter-tissue forces in the coordination of complex morphogenesis involving distinct tissues.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 10, 2018.
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Mechanical Coupling Coordinates the Co-elongation of Axial and Paraxial Tissues in Avian Embryos
Fengzhu Xiong, Wenzhe Ma, Bertrand Bénazéraf, L. Mahadevan, Olivier Pourquié
bioRxiv 412866; doi: https://doi.org/10.1101/412866
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Mechanical Coupling Coordinates the Co-elongation of Axial and Paraxial Tissues in Avian Embryos
Fengzhu Xiong, Wenzhe Ma, Bertrand Bénazéraf, L. Mahadevan, Olivier Pourquié
bioRxiv 412866; doi: https://doi.org/10.1101/412866

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