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The PCR Simulator: an on-line application for teaching Design of Experiments and the polymerase chain reaction

View ORCID ProfileHarold Fellermann, View ORCID ProfileBen Shirt-Ediss, Jerzy W. Koryza, Matthew Linsley, View ORCID ProfileDennis W. Lendrem, View ORCID ProfileThomas P. Howard
doi: https://doi.org/10.1101/415042
Harold Fellermann
1School of Computing, Faculty of Science, Agriculture and Engineering, Newcastle University, Newcastle-Upon-Tyne, NE1 7RU, United Kingdom
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Ben Shirt-Ediss
1School of Computing, Faculty of Science, Agriculture and Engineering, Newcastle University, Newcastle-Upon-Tyne, NE1 7RU, United Kingdom
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Jerzy W. Koryza
1School of Computing, Faculty of Science, Agriculture and Engineering, Newcastle University, Newcastle-Upon-Tyne, NE1 7RU, United Kingdom
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Matthew Linsley
2School of Mathematics, Statistics and Physics, Faculty of Science, Agriculture and Engineering, Newcastle University, Newcastle-Upon-Tyne, NE1 7RU, United Kingdom
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Dennis W. Lendrem
3Institute for Cellular Medicine and NIHR Biomedical Research Centre, Newcastle University, Newcastle-Upon-Tyne, NE2 4HH, United Kingdom
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Thomas P. Howard
4School of Natural and Environmental Sciences, Faculty of Science, Agriculture and Engineering, Newcastle University, Newcastle-Upon-Tyne, NE1 7RU, United Kingdom
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Abstract

Our PCR Simulator is a web-based application designed to introduce concepts of multi-factorial experimental design and support teaching of the polymerase chain reaction. Learners select experimental settings and receive results of their simulated reactions quickly, allowing rapid iteration between data generation and analysis. This enables the student to perform complex iterative experimental design strategies within a short teaching session. Here we provide a short overview of the user interface and underpinning model, and describe our experience using this tool in a teaching environment.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 18, 2018.
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The PCR Simulator: an on-line application for teaching Design of Experiments and the polymerase chain reaction
Harold Fellermann, Ben Shirt-Ediss, Jerzy W. Koryza, Matthew Linsley, Dennis W. Lendrem, Thomas P. Howard
bioRxiv 415042; doi: https://doi.org/10.1101/415042
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The PCR Simulator: an on-line application for teaching Design of Experiments and the polymerase chain reaction
Harold Fellermann, Ben Shirt-Ediss, Jerzy W. Koryza, Matthew Linsley, Dennis W. Lendrem, Thomas P. Howard
bioRxiv 415042; doi: https://doi.org/10.1101/415042

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