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Human cortical dynamics during full-body heading changes

View ORCID ProfileKlaus Gramann, Friederike U. Hohlefeld, View ORCID ProfileLukas Gehrke, View ORCID ProfileMarius Klug
doi: https://doi.org/10.1101/417972
Klaus Gramann
Institute of Psychology and Ergonomics, Technische Universität Berlin, Germany
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  • For correspondence: klaus.gramann@tu-berlin.de
Friederike U. Hohlefeld
Institute of Psychology and Ergonomics, Technische Universität Berlin, Germany
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Lukas Gehrke
Institute of Psychology and Ergonomics, Technische Universität Berlin, Germany
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Marius Klug
Institute of Psychology and Ergonomics, Technische Universität Berlin, Germany
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Abstract

The retrosplenial complex (RSC) plays a crucial role in spatial orientation by computing heading direction and translating between distinct spatial reference frames based on multi-sensory information. While invasive studies allow investigating heading computation in moving animals, established non-invasive analyses of human brain dynamics are restricted to stationary setups. To investigate the role of the RSC in heading computation of actively moving humans, we used a Mobile Brain/Body Imaging approach synchronizing electroencephalography with motion capture and virtual reality. Data from physically rotating participants were contrasted with rotations based only on visual flow. During physical rotation, varying rotation velocities were accompanied by pronounced wide frequency band synchronization in RSC, the parietal and occipital cortices. In contrast, the visual flow rotation condition was associated with pronounced alpha band desynchronization, replicating previous findings in desktop navigation studies, and notably absent during physical rotation. These results suggest an involvement of the human RSC in heading computation based on visual, vestibular, and proprioceptive input and implicate revisiting traditional findings of alpha desynchronization in areas of the navigation network during spatial orientation in movement-restricted participants.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • klaus.gramann{at}tu-berlin.de, friederike.hohlefeld{at}tu-berlin.de, lukas.gehrke{at}tu-berlin.de, marius.klug{at}tu-berlin.de

  • Additional cortical clusters as well as two non-brain clusters were analysed and included in figures. New analyses were incorporated to address the impact of rotational velocity on brain dynamics. New figures were added. Orcid IDs were added were existing. Supplemental updated and added.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted March 03, 2021.
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Human cortical dynamics during full-body heading changes
Klaus Gramann, Friederike U. Hohlefeld, Lukas Gehrke, Marius Klug
bioRxiv 417972; doi: https://doi.org/10.1101/417972
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Human cortical dynamics during full-body heading changes
Klaus Gramann, Friederike U. Hohlefeld, Lukas Gehrke, Marius Klug
bioRxiv 417972; doi: https://doi.org/10.1101/417972

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