Tau Secretion and Propagation Is Regulated by p300/CBP via Autophagy-Lysosomal Pathway in Tauopathy

Xu Chen; Yaqiao Li; Chao Wang; Yinyan Tang; Sue-Ann Mok; Richard M. Tsai; Julio C. Rojas; Anna Karydas; Bruce L. Miller; Adam L. Boxer; Jason E. Gestwicki; Ana Maria Cuervo; Michelle Arkin; Li Gan

doi:10.1101/418640

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Tau Secretion and Propagation Is Regulated by p300/CBP via Autophagy-Lysosomal Pathway in Tauopathy

Xu Chen, Yaqiao Li, Chao Wang, Yinyan Tang, Sue-Ann Mok, Richard M. Tsai, Julio C. Rojas, Anna Karydas, Bruce L. Miller, Adam L. Boxer, Jason E. Gestwicki, Ana Maria Cuervo, Michelle Arkin, Li Gan

doi: https://doi.org/10.1101/418640

Xu Chen

Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94158, USADepartment of Neurology, University of California, San Francisco, CA 94158, USA

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For correspondence: lgan@gladstone.ucsf.edu xu.chen@gladstone.ucsf.edu

Yaqiao Li

Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94158, USA

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Chao Wang

Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94158, USADepartment of Neurology, University of California, San Francisco, CA 94158, USA

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Yinyan Tang

Small Molecule Discovery Center, Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA

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Sue-Ann Mok

Institute for Neurodegenerative Disease, Department of Pharmaceutical Chemistry, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158, USA

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Richard M. Tsai