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Tau Secretion and Propagation Is Regulated by p300/CBP via Autophagy-Lysosomal Pathway in Tauopathy

Xu Chen, Yaqiao Li, Chao Wang, Yinyan Tang, Sue-Ann Mok, Richard M. Tsai, Julio C. Rojas, Anna Karydas, Bruce L. Miller, Adam L. Boxer, Jason E. Gestwicki, Ana Maria Cuervo, Michelle Arkin, Li Gan
doi: https://doi.org/10.1101/418640
Xu Chen
Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94158, USADepartment of Neurology, University of California, San Francisco, CA 94158, USA
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  • For correspondence: lgan@gladstone.ucsf.edu xu.chen@gladstone.ucsf.edu
Yaqiao Li
Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94158, USA
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Chao Wang
Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94158, USADepartment of Neurology, University of California, San Francisco, CA 94158, USA
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Yinyan Tang
Small Molecule Discovery Center, Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA
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Sue-Ann Mok
Institute for Neurodegenerative Disease, Department of Pharmaceutical Chemistry, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158, USA
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Richard M. Tsai
Department of Neurology, University of California, San Francisco, CA 94158, USAMemory and Aging Center, University of California, San Francisco, CA 94158, USA
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Julio C. Rojas
Department of Neurology, University of California, San Francisco, CA 94158, USAMemory and Aging Center, University of California, San Francisco, CA 94158, USA
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Anna Karydas
Department of Neurology, University of California, San Francisco, CA 94158, USAMemory and Aging Center, University of California, San Francisco, CA 94158, USA
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Bruce L. Miller
Department of Neurology, University of California, San Francisco, CA 94158, USAMemory and Aging Center, University of California, San Francisco, CA 94158, USA
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Adam L. Boxer
Department of Neurology, University of California, San Francisco, CA 94158, USAMemory and Aging Center, University of California, San Francisco, CA 94158, USA
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Jason E. Gestwicki
Institute for Neurodegenerative Disease, Department of Pharmaceutical Chemistry, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158, USA
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Ana Maria Cuervo
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA,Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
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Michelle Arkin
Small Molecule Discovery Center, Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA
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Li Gan
Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94158, USADepartment of Neurology, University of California, San Francisco, CA 94158, USA
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  • For correspondence: lgan@gladstone.ucsf.edu xu.chen@gladstone.ucsf.edu
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Posted September 14, 2018.
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Tau Secretion and Propagation Is Regulated by p300/CBP via Autophagy-Lysosomal Pathway in Tauopathy
Xu Chen, Yaqiao Li, Chao Wang, Yinyan Tang, Sue-Ann Mok, Richard M. Tsai, Julio C. Rojas, Anna Karydas, Bruce L. Miller, Adam L. Boxer, Jason E. Gestwicki, Ana Maria Cuervo, Michelle Arkin, Li Gan
bioRxiv 418640; doi: https://doi.org/10.1101/418640
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Tau Secretion and Propagation Is Regulated by p300/CBP via Autophagy-Lysosomal Pathway in Tauopathy
Xu Chen, Yaqiao Li, Chao Wang, Yinyan Tang, Sue-Ann Mok, Richard M. Tsai, Julio C. Rojas, Anna Karydas, Bruce L. Miller, Adam L. Boxer, Jason E. Gestwicki, Ana Maria Cuervo, Michelle Arkin, Li Gan
bioRxiv 418640; doi: https://doi.org/10.1101/418640

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