Tau Secretion and Propagation Is Regulated by p300/CBP via Autophagy-Lysosomal Pathway in Tauopathy

Xu Chen; Yaqiao Li; Chao Wang; Yinyan Tang; Sue-Ann Mok; Richard M. Tsai; Julio C. Rojas; Anna Karydas; Bruce L. Miller; Adam L. Boxer; Jason E. Gestwicki; Ana Maria Cuervo; Michelle Arkin; Li Gan

doi:10.1101/418640

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Tau Secretion and Propagation Is Regulated by p300/CBP via Autophagy-Lysosomal Pathway in Tauopathy

Xu Chen, Yaqiao Li, Chao Wang, Yinyan Tang, Sue-Ann Mok, Richard M. Tsai, Julio C. Rojas, Anna Karydas, Bruce L. Miller, Adam L. Boxer, Jason E. Gestwicki, Ana Maria Cuervo, Michelle Arkin, Li Gan

doi: https://doi.org/10.1101/418640

Xu Chen

1Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94158, USA

2Department of Neurology, University of California, San Francisco, CA 94158, USA

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For correspondence: lgan@gladstone.ucsf.edu xu.chen@gladstone.ucsf.edu

Yaqiao Li

1Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94158, USA

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Chao Wang

1Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94158, USA

2Department of Neurology, University of California, San Francisco, CA 94158, USA

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Yinyan Tang

3Small Molecule Discovery Center, Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA

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Sue-Ann Mok

4Institute for Neurodegenerative Disease, Department of Pharmaceutical Chemistry, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158, USA

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Richard M. Tsai

2Department of Neurology, University of California, San Francisco, CA 94158, USA

5Memory and Aging Center, University of California, San Francisco, CA 94158, USA

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Julio C. Rojas

2Department of Neurology, University of California, San Francisco, CA 94158, USA

5Memory and Aging Center, University of California, San Francisco, CA 94158, USA

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Anna Karydas

2Department of Neurology, University of California, San Francisco, CA 94158, USA

5Memory and Aging Center, University of California, San Francisco, CA 94158, USA

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Bruce L. Miller

2Department of Neurology, University of California, San Francisco, CA 94158, USA

5Memory and Aging Center, University of California, San Francisco, CA 94158, USA

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Adam L. Boxer

2Department of Neurology, University of California, San Francisco, CA 94158, USA

5Memory and Aging Center, University of California, San Francisco, CA 94158, USA

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Jason E. Gestwicki

4Institute for Neurodegenerative Disease, Department of Pharmaceutical Chemistry, Weill Institute for Neurosciences, University of California, San Francisco, CA 94158, USA

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Ana Maria Cuervo

6Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA,

7Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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Michelle Arkin

3Small Molecule Discovery Center, Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA

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Li Gan

1Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94158, USA

2Department of Neurology, University of California, San Francisco, CA 94158, USA

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For correspondence: lgan@gladstone.ucsf.edu xu.chen@gladstone.ucsf.edu

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Tau Secretion and Propagation Is Regulated by p300/CBP via Autophagy-Lysosomal Pathway in Tauopathy

Xu Chen, Yaqiao Li, Chao Wang, Yinyan Tang, Sue-Ann Mok, Richard M. Tsai, Julio C. Rojas, Anna Karydas, Bruce L. Miller, Adam L. Boxer, Jason E. Gestwicki, Ana Maria Cuervo, Michelle Arkin, Li Gan

bioRxiv 418640; doi: https://doi.org/10.1101/418640

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Tau Secretion and Propagation Is Regulated by p300/CBP via Autophagy-Lysosomal Pathway in Tauopathy

Xu Chen, Yaqiao Li, Chao Wang, Yinyan Tang, Sue-Ann Mok, Richard M. Tsai, Julio C. Rojas, Anna Karydas, Bruce L. Miller, Adam L. Boxer, Jason E. Gestwicki, Ana Maria Cuervo, Michelle Arkin, Li Gan

bioRxiv 418640; doi: https://doi.org/10.1101/418640

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