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Separate lanes for math and reading in the white matter highways of the human brain

View ORCID ProfileMareike Grotheer, Zonglei Zhen, Kalanit Grill-Spector
doi: https://doi.org/10.1101/420216
Mareike Grotheer
1Psychology Department, Stanford University, Stanford, USA
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  • For correspondence: grotheer@stanford.edu
Zonglei Zhen
2Beijing Key Laboratory of Applied Experimental Psychology, Faculty of Psychology, Beijing Normal University, Beijing, China
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Kalanit Grill-Spector
1Psychology Department, Stanford University, Stanford, USA
3Stanford Neurosciences Institute, Stanford University, Stanford, USA
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Abstract

Math and reading involve distributed brain networks and learning disabilities associated with these skills have a high rate of co-occurrence. However, it is unknown what are shared vs. dissociated white matter substrates of math and reading networks. Here we address this question using an innovative, multimodal approach applying functional MRI, diffusion MRI, and quantitative MRI to define these networks and evaluate structural properties of their fascicles. Results reveal that the superior longitudinal (SLF) and arcuate (AF) fascicles are shared between math and reading networks. Strikingly, within these fascicles, reading- and math-related tracts are segregated into parallel sub-bundles and show structural differences related to myelination. These novel findings: (i) open a new avenue of research enabling linkage of sub-bundles within fascicles to behavior and (ii) may explain both isolated and comorbid cases of math and reading disabilities, which may be associated with white matter abnormalities within sub-bundles or entire fascicles, respectively.

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Posted September 17, 2018.
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Separate lanes for math and reading in the white matter highways of the human brain
Mareike Grotheer, Zonglei Zhen, Kalanit Grill-Spector
bioRxiv 420216; doi: https://doi.org/10.1101/420216
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Separate lanes for math and reading in the white matter highways of the human brain
Mareike Grotheer, Zonglei Zhen, Kalanit Grill-Spector
bioRxiv 420216; doi: https://doi.org/10.1101/420216

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